Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion
Yıl: 2023 Cilt: 30 Sayı: 11 Sayfa Aralığı: 14525 - 1458 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2023.09.264 İndeks Tarihi: 01-12-2023
Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion
Öz: Aim: This study investigates the protective effects of Dinoprost against Ischemia/ Reperfusion (I/R) damage in the rat ovary, focusing on the expression of cyclooxygenase-2 (COX-2), Interleukin-1β (IL1β), and Tumor Necrosis Factor-α (TNF-α). Additionally, the impact of Dinoprost on reducing hemorrhage in the ovarian tissue is evaluated. Materials and Methods: A total of 24 rats were randomly divided into four groups: Control, Ischemia (Isch), I/R, and Dino+I/R. Ischemia was induced by clamping the ovarian blood supply, followed by reperfusion. Dinoprost was administered before reperfusion in the Dino+I/R group. COX-2, IL1β, and TNF-α expression levels were assessed through histochemical and immunochemical analyses. Hemorrhage in the ovarian tissue was also examined. Results: The Dino+I/R group exhibited a significant decrease in COX-2 expression compared to the Isch and I/R groups (p<0.05). However, there were no significant changes in the expression levels of IL1β and TNF-α among the groups. Notably, the Dino+I/R group showed significantly reduced hemorrhage compared to the Isch and I/R groups (p<0.05). Conclusion: Dinoprost demonstrated a protective effect against I/R damage in the rat ovary, primarily by attenuating COX-2 expression and reducing hemorrhage. These findings suggest the potential therapeutic utility of Dinoprost in mitigating ovarian I/R injury, emphasizing its role in preserving ovarian function and fertility.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KARAKUŞ S, özkaraca m (2023). Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. , 14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| Chicago | KARAKUŞ Savas,özkaraca mustafa Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. (2023): 14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| MLA | KARAKUŞ Savas,özkaraca mustafa Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. , 2023, ss.14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| AMA | KARAKUŞ S,özkaraca m Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. . 2023; 14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| Vancouver | KARAKUŞ S,özkaraca m Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. . 2023; 14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| IEEE | KARAKUŞ S,özkaraca m "Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion." , ss.14525 - 1458, 2023. 10.5455/annalsmedres.2023.09.264 |
| ISNAD | KARAKUŞ, Savas - özkaraca, mustafa. "Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion". (2023), 14525-1458. https://doi.org/10.5455/annalsmedres.2023.09.264 |
| APA | KARAKUŞ S, özkaraca m (2023). Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. Annals of Medical Research, 30(11), 14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| Chicago | KARAKUŞ Savas,özkaraca mustafa Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. Annals of Medical Research 30, no.11 (2023): 14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| MLA | KARAKUŞ Savas,özkaraca mustafa Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. Annals of Medical Research, vol.30, no.11, 2023, ss.14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| AMA | KARAKUŞ S,özkaraca m Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. Annals of Medical Research. 2023; 30(11): 14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| Vancouver | KARAKUŞ S,özkaraca m Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion. Annals of Medical Research. 2023; 30(11): 14525 - 1458. 10.5455/annalsmedres.2023.09.264 |
| IEEE | KARAKUŞ S,özkaraca m "Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion." Annals of Medical Research, 30, ss.14525 - 1458, 2023. 10.5455/annalsmedres.2023.09.264 |
| ISNAD | KARAKUŞ, Savas - özkaraca, mustafa. "Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion". Annals of Medical Research 30/11 (2023), 14525-1458. https://doi.org/10.5455/annalsmedres.2023.09.264 |
