Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment

Tanbek, Kevser; Kose, Evren

doi:10.5455/annalsmedres.2023.10.290

Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment

Kevser TANBEK, (İnönü Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Malatya, Türkiye)

Evren KOSE (İnönü Üniversitesi, Tıp Fakültesi, Anatomi Anabilim Dalı, Malatya, Türkiye)

Annals of Medical Research

11 5

Yıl: 2023 Cilt: 30 Sayı: 11 Sayfa Aralığı: 1464 - 1468 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2023.10.290 İndeks Tarihi: 01-12-2023

Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment

Öz:

Aim: Pemetrexed (PMTX) is a multi-targeted anticancer agent that exerts its antifolate effect by disrupting the folate dependent metabolic processes underlying cell proliferation. Kidney toxicity is a common side effect of anticancer agents. Chrysin (Chr) is a powerful antioxidant compound abundant in plant extracts, honey, and bee propolis. The aim of this study is to investigate the effect of the combined use of chrysin, a natural flavonoid, against the possible harmful effects of PMTX on kidney tissue. Materials and Methods: 50 Wistar albino male rats were divided; Control, Sham, PMTX, Chr, PMTX+Chr groups. Sham (1ml corn oil/day), Chr (50mg/kg/day) by oral gavage, PMTX (1mg/kg/week) by i.p., PMTX+Chr (PMTX;1mg/kg/week, Chr;50mg/kg/day) were given at the same time every day. At the end of 4 weeks of the study, kidney tissues and blood were collected. Creatinine (Cr) and blood-urea-nitrogen (BUN) analyzed in serum by ELISA. The malondialdehyde (MDA), superoxide dismutase (SOD) activities and total antioxidant status (TAS), total oxidant status (TOS), OSI also were measured in kidney tissue. Results: Indicators of oxidative stress, MDA was elevated and antioxidant activity was reduced in the PMTX groups compared to Control and Sham groups (p<0.05). In the PMTX+Chr group, MDA, BUN, Cr and TOS were decreased, SOD and TAS was increased compared to PMTX group (p <0.05). Conclusion: Chr exhibited ameliorative effects on PMTX induced nephrotoxicity increasing antioxidant activity and reducing oxidative damage.

Anahtar Kelime: Pemetrexed Chrysin Kidney Oxidative stress Rat

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Tanbek K, Kose E (2023). Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. , 1464 - 1468. 10.5455/annalsmedres.2023.10.290
Chicago	Tanbek Kevser,Kose Evren Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. (2023): 1464 - 1468. 10.5455/annalsmedres.2023.10.290
MLA	Tanbek Kevser,Kose Evren Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. , 2023, ss.1464 - 1468. 10.5455/annalsmedres.2023.10.290
AMA	Tanbek K,Kose E Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. . 2023; 1464 - 1468. 10.5455/annalsmedres.2023.10.290
Vancouver	Tanbek K,Kose E Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. . 2023; 1464 - 1468. 10.5455/annalsmedres.2023.10.290
IEEE	Tanbek K,Kose E "Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment." , ss.1464 - 1468, 2023. 10.5455/annalsmedres.2023.10.290
ISNAD	Tanbek, Kevser - Kose, Evren. "Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment". (2023), 1464-1468. https://doi.org/10.5455/annalsmedres.2023.10.290

APA	Tanbek K, Kose E (2023). Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. Annals of Medical Research, 30(11), 1464 - 1468. 10.5455/annalsmedres.2023.10.290
Chicago	Tanbek Kevser,Kose Evren Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. Annals of Medical Research 30, no.11 (2023): 1464 - 1468. 10.5455/annalsmedres.2023.10.290
MLA	Tanbek Kevser,Kose Evren Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. Annals of Medical Research, vol.30, no.11, 2023, ss.1464 - 1468. 10.5455/annalsmedres.2023.10.290
AMA	Tanbek K,Kose E Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. Annals of Medical Research. 2023; 30(11): 1464 - 1468. 10.5455/annalsmedres.2023.10.290
Vancouver	Tanbek K,Kose E Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment. Annals of Medical Research. 2023; 30(11): 1464 - 1468. 10.5455/annalsmedres.2023.10.290
IEEE	Tanbek K,Kose E "Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment." Annals of Medical Research, 30, ss.1464 - 1468, 2023. 10.5455/annalsmedres.2023.10.290
ISNAD	Tanbek, Kevser - Kose, Evren. "Chrysin protects against kidney tissue oxidative damage caused by pemetrexed used in cancer treatment". Annals of Medical Research 30/11 (2023), 1464-1468. https://doi.org/10.5455/annalsmedres.2023.10.290