Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application
Yıl: 2023 Cilt: 48 Sayı: 3 Sayfa Aralığı: 385 - 394 Metin Dili: İngilizce DOI: 10.55262/fabadeczacilik.1313014 İndeks Tarihi: 01-12-2023
Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application
Öz: Sertraline is one of the selective serotonin reuptake inhibitors indicated in major depressive disorder. Schizophrenia is a mental disorder with frequent depressive symptoms. Sertraline is thought to be useful for the treatment of depressive symptoms in schizophrenia. The objective of this study is to formulate sertraline-containing nanofiber strips produced by the electrospinning process, which can be easily dispersed by the buccal route, suitable for the use of schizophrenia patients. Here, various ratios (%5, %7.5 and %10) of polyvinyl pyrrolidone (PVP) polymer solutions were prepared, and electrical conductivity, viscosity and surface tension characterization studies were performed on polymer solutions. After characterization studies, a polymer solution containing 5% PVP was selected to prepare nanofibers. Nanofibers were obtained by using the electrospinning method, each strip containing 5 mg sertraline. It was observed that the optimum formulation selected nanofiber had an average particle diameter of 371-439 nm in the SEM image. Tensile strength and elongation at break percentage values of 5% PVP-sertraline nanofibers values were 0.449±0.284 (Mpa) and 22.6±3.66 (%), respectively. The loading capacity and encapsulation efficiency of the formulation are 4.53%±0.31 and 79.61±10.56 respectively. In vitro drug dissolution studies showed that sertraline-containing buccal nanofibers conformed to the Hixson-Crowell kinetic model.
Anahtar Kelime: Bukkal Uygulamaya Yönelik Sertralin İçeren Nanofiber Şerit Geliştirilmesi ve Karakterizasyonu
Öz: Sertralin, majör depresif bozuklukta belirtilen seçici serotonin geri alım inhibitörlerinden biridir. Şizofreni, sık sık depresif belirtiler gösteren bir ruhsal bozukluktur. Sertralinin şizofrenide depresif semptomların tedavisinde faydalı olduğu düşünülmektedir. Bu çalışmanın amacı, şizofreni hastalarının kullanımına uygun, elektroeğirme işlemi ile üretilmiş, bukkal yolla kolaylıkla dağılabilen, sertralin içerikli nanolif stripler geliştirmektir. Burada çeşitli oranlarda (%5, %7.5 ve %10) polivinil pirolidon (PVP) polimer çözeltileri hazırlanmış ve polimer çözeltileri üzerinde elektriksel iletkenlik, viskozite ve yüzey gerilimi karakterizasyon çalışmaları yapılmıştır. Karakterizasyon çalışmalarından sonra, optimum nanolifleri hazırlamak için %5 PVP içeren bir polimer çözeltisi seçilmiştir. Her strip 5 mg sertralin içeren elektroeğirme yöntemi kullanılarak nanolifler elde edilmiştir. Optimum formülasyon seçilen nanofiberin SEM görüntüsünde ortalama 371-439 nm partikül çapına sahip olduğu gözlenmiştir. %5 PVP-sertralin nanoliflerinin gerilme direnci ve kopma yüzdesindeki uzama değerleri sırasıyla 0.449±0.284 (Mpa) ve 22.6±3.66 (%)’dir. Formülasyonun yükleme kapasitesi ve kapsülleme verimliliği sırasıyla %4.53±0.31 ve %79.61±10.56’dır. İn vitro ilaç çözünme hızı çalışmaları, sertralin içeren bukkal nanoliflerin Hixson-Crowell kinetik modeline uygun olduğunu göstermiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Özcan K, Saral Acarca E, ILBASMIS TAMER S (2023). Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. , 385 - 394. 10.55262/fabadeczacilik.1313014 |
| Chicago | Özcan Kutsal,Saral Acarca Eylül Su,ILBASMIS TAMER SIBEL Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. (2023): 385 - 394. 10.55262/fabadeczacilik.1313014 |
| MLA | Özcan Kutsal,Saral Acarca Eylül Su,ILBASMIS TAMER SIBEL Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. , 2023, ss.385 - 394. 10.55262/fabadeczacilik.1313014 |
| AMA | Özcan K,Saral Acarca E,ILBASMIS TAMER S Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. . 2023; 385 - 394. 10.55262/fabadeczacilik.1313014 |
| Vancouver | Özcan K,Saral Acarca E,ILBASMIS TAMER S Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. . 2023; 385 - 394. 10.55262/fabadeczacilik.1313014 |
| IEEE | Özcan K,Saral Acarca E,ILBASMIS TAMER S "Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application." , ss.385 - 394, 2023. 10.55262/fabadeczacilik.1313014 |
| ISNAD | Özcan, Kutsal vd. "Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application". (2023), 385-394. https://doi.org/10.55262/fabadeczacilik.1313014 |
| APA | Özcan K, Saral Acarca E, ILBASMIS TAMER S (2023). Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. FABAD Journal of Pharmaceutical Sciences, 48(3), 385 - 394. 10.55262/fabadeczacilik.1313014 |
| Chicago | Özcan Kutsal,Saral Acarca Eylül Su,ILBASMIS TAMER SIBEL Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. FABAD Journal of Pharmaceutical Sciences 48, no.3 (2023): 385 - 394. 10.55262/fabadeczacilik.1313014 |
| MLA | Özcan Kutsal,Saral Acarca Eylül Su,ILBASMIS TAMER SIBEL Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. FABAD Journal of Pharmaceutical Sciences, vol.48, no.3, 2023, ss.385 - 394. 10.55262/fabadeczacilik.1313014 |
| AMA | Özcan K,Saral Acarca E,ILBASMIS TAMER S Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. FABAD Journal of Pharmaceutical Sciences. 2023; 48(3): 385 - 394. 10.55262/fabadeczacilik.1313014 |
| Vancouver | Özcan K,Saral Acarca E,ILBASMIS TAMER S Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application. FABAD Journal of Pharmaceutical Sciences. 2023; 48(3): 385 - 394. 10.55262/fabadeczacilik.1313014 |
| IEEE | Özcan K,Saral Acarca E,ILBASMIS TAMER S "Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application." FABAD Journal of Pharmaceutical Sciences, 48, ss.385 - 394, 2023. 10.55262/fabadeczacilik.1313014 |
| ISNAD | Özcan, Kutsal vd. "Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application". FABAD Journal of Pharmaceutical Sciences 48/3 (2023), 385-394. https://doi.org/10.55262/fabadeczacilik.1313014 |
