Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls
Yıl: 2023 Cilt: 33 Sayı: 5 Sayfa Aralığı: 536 - 540 Metin Dili: İngilizce DOI: 10.54005/geneltip.1306834 İndeks Tarihi: 06-12-2023
Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls
Öz: Aim: This study (1) compared skeletal muscle mass (SMM) and muscle strength in familial Mediterranean fever (FMF) patients with those of healthy controls (HCs) and (2) investigated the association of SMM and muscle strength with disease severity and quality of life (QOL). Materials and Methods: This study included 31 FMF patients and 30 matched HCs. Disease severity was evaluated using the International Severity Scoring System for FMF (ISSF). Body composition parameters were measured using a bioelectrical impedance analysis. Grip and pinch strengths were calculated for muscle strength. Health status was assessed with Short Form 36 (SF-36). Results: The all-body composition parameters of the FMF patients, including SMM, were similar to those of the HCs, with significantly lower grip and pinch strengths. All SF-36 scores of the FMF patients were significantly lower than those of the HCs. Positive correlations were observed between muscle-related indices and pinch strength for some SF-36 domains. Conclusion: Muscle- or fat-related indices were similar among adult patients with FMF and the HCs. In contrast, patients with FMF had a poorer health-related QOL and lower grip and pinch strengths than the HCs. Further studies are needed to determine the clinical significance of these correlations in patients with FMF.
Anahtar Kelime: Erişkin Ailevi Akdeniz Ateşi Hastalarında İskelet Kası Kütlesi, Kas Kuvveti ve Yaşam Kalitesi: Sağlıklı Kontrollerle Karşılaştırmalı Bir Çalışma
Öz: Amaç: Bu çalışmanın amacı, (1) erişkin ailevi Akdeniz ateşi (AAA) hastalarında iskelet kası kütlesi (İKK) ve kas kuvvetini sağlıklı kontrollerle (SK) karşılaştırmak ve (2) İKK ve kas kuvveti ile hastalık şiddeti ve yaşam kalitesi arasındaki ilişkiyi araştırmaktı. Gereç ve Yöntemler: Çalışmaya 31 AAA hastası ve eşleştirilmiş 30 SK dâhil edildi. Hastalık şiddeti, AAA için uluslararası şiddet skorlama sistemi (ISSF) kullanılarak değerlendirildi. Vücut kompozisyon parametreleri, biyoelektrik impedans analizi (BİA) kullanılarak ölçüldü. Kas kuvveti için el kavrama ve parmak kavrama kuvvetleri değerlendirildi. Yaşam kalitesi, Kısa Form-36 (KF-36) kullanılarak değerlendirildi. Bulgular: AAA hastalarının İKK dâhil tüm vücut kompozisyon parametreleri SK gruba ile benzer, el kavrama ve parmak kavrama kuvvetleri ise istatistiksel olarak anlamlı düşüktü. AAA hastalarının tüm KF-36 skorları SK grubundan anlamlı düşüktü. Kasla ilgili indeksler ve parmak kavrama kuvveti ile bazı KF-36 skorları arasında pozitif korelasyonlar bulundu. Sonuç: Bu çalışma, erişkin AAA hastalarında BİA ile ölçülen kas veya yağ ile ilişkili indekslerin SK grubu ile benzer olduğunu göstermiştir. Buna karşılık, AAA hastalarında sağlıkla ilgili yaşam kalitesi ve el kavrama ve parmak kavrama kuvvetleri SK grubundan daha düşüktü. FMF hastalarında bu korelasyonların klinik önemini belirlemek için ise daha ileri çalışmalara ihtiyaç vardır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1.Onen F. Familial Mediterranean fever. Rheumatol Int 2006; 26(6):489- 496.
- 2.Ozdogan H, Ugurlu S. Familial Mediterranean Fever. Presse Med 2019; 48(1 Pt 2):e61-e76.
- 3.Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, et al. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell 2007; 28(2):214-227.
- 4.Baykal Y, Saglam K, Yilmaz MI, Taslipinar A, Akinci SB, Inal A. Serum sIL-2r, IL-6, IL-10 and TNF-alpha level in familial Mediterranean fever patients. Clin Rheumatol 2003; 22(2):99-101.
- 5.Notarnicola C, Didelot MN, Seguret F, Demaille J, Touitou I. Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever. Genes Immun 2002; 3(1):43-45.
- 6.Londhe P, Guttridge DC. Inflammation induced loss of skeletal muscle. Bone 2015; 80:131-142.
- 7.Durmaz Y, Ilhanli İ, Cengiz AK, Kaptanoğlu E, Özkan Hasbek Z, Hizmetli S. Association Between Familial Mediterranean Fever and Cachexia in Females. Arch Rheumatol 2020; 35(4):477-485.
- 8.Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997; 40(10):1879-1885.
- 9.Demirkaya E, Acikel C, Hashkes P, Gattorno M, Gul A, Ozdogan H, et al. Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF). Ann Rheum Dis 2016; 75(6):1051-1056.
- 10.Kyle UG, Piccoli A, Pichard C. Body composition measurements: interpretation finally made easy for clinical use. Curr Opin Clin Nutr Metab Care 2003; 6(4):387-393.
- 11.Czartoryski P, Garcia J, Manimaleth R, Napolitano P, Watters H, Weber C, et al. Body composition assessment: a comparison of the DXA, Inbody 270, and Omron. J Exercise Nutr 2020; 3(1).
- 12.Fess EE. Grip strength. In J.S. Casanova, editor. Clinical assessment recommendations. 3rd ed. American Society for Hand Therapists, New Jersey; 1992. p. 41-45.
- 13.Mathiowetz V, Kashman N, Volland G, Weber K, Dowe M, Rogers Muscle Mass in Familial Mediterranean Fever - Cüce et al. S. Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil 1985; 66(2):69-74.
- 14.Kocyigit H. Reliability and validity of the Turkish version of short form- 36 (SF-36): a study in a group of patients will rheumatic diseases. Turk J Drugs Ther 1999; 12:102-106.
- 15.Sar İ, Demir T, Gerçek C, Servet A, Birlik M, Tunca M, et al. Ailevi Akdeniz Ateşi Hastalarında Vücut Kompozisyonunun Değerlendirilmesi. Fırat Tıp Dergisi 2009; 14(3):181-185.
- 16.Nogueira-Ferreira R, Sousa-Nunes F, Leite-Moreira A, Moreira-Costa L, Vitorino R, Lara Santos L, et al. Cancer- and cardiac-induced cachexia: same fate through different inflammatory mediators? Inflamm Res 2022; 71(7-8):771-783.
- 17.Challal S, Minichiello E, Boissier MC, Semerano L. Cachexia and adiposity in rheumatoid arthritis. Relevance for disease management and clinical outcomes. Joint Bone Spine 2016; 83(2):127-133.
- 18.Santo RCE, Fernandes KZ, Lora PS, Filippin LI, Xavier RM. Prevalence of rheumatoid cachexia in rheumatoid arthritis: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2018; 9(5):816-25.
- 19.Huffman KM, Jessee R, Andonian B, Davis BN, Narowski R, Huebner JL, et al. Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability. Arthritis Res Ther 2017; 19(1):12.
- 20.Babaoglu H, Armagan B, Bodakci E, Satis H, Atas N, Sari A, et al. Predictors of persistent inflammation in familial Mediterranean fever and association with damage. Rheumatology (Oxford) 2021; 60(1):333-339.
- 21.Tore NG, Sari F, Saraç DC, Bayram S, Satış H, Karadeniz H, et al. Decreased exercise capacity, strength, physical activity level and quality of life in adult patients with familial Mediterranean fever. Turk J Med Sci 2021; 51(4):1712-1718.
- 22.Alayli G, Durmus D, Ozkaya O, Sen HE, Nalcacioglu H, Bilgici A, et al. Functional capacity, strength, and quality of life in children and youth with familial Mediterranean fever. Pediatr Phys Ther 2014; 26(3):347- 352.
- 23.Johansson RS, Westling G. Signals in tactile afferents from the fingers eliciting adaptive motor responses during precision grip. Exp Brain Res 1987; 66(1):141-154.
- 24.McEwan T, Bhambra J, Liew DF, Robinson PC. Systematic review of colchicine neuromyopathy: Risk factors, duration and resolution. Semin Arthritis Rheum 2023; 58:152150.
- 25.Sahin S, Yalcin I, Senel S, Ataseven H, Uslu A, Yildirim O, et al. Assesment life quality of familial Mediterranean fever patients by short form-36 and its relationship with disease parameters. Eur Rev Med Pharmacol Sci 2013; 17(7):958-963.
- 26.Fukuda W, Omoto A, Ohta T, Majima S, Kimura T, Tanaka T, et al. Low body mass index is associated with impaired quality of life in patients with rheumatoid arthritis. Int J Rheum Dis 2013; 16(3):297-302.
- 27.Kim SC, Lee YG, Park SB, Kim TH, Lee KH. Muscle Mass, Strength, Mobility, Quality of Life, and Disease Severity in Ankylosing Spondylitis Patients: A Preliminary Study. Ann Rehabil Med 2017;41(6):990-997.
- 28.Hayashida I, Tanimoto Y, Takahashi Y, Kusabiraki T, Tamaki J. Correlation between muscle strength and muscle mass, and their association with walking speed, in community-dwelling elderly Japanese individuals. PLoS One 2014; 9(11):e111810.
| APA | Cüce İ, Yıldızhan R, KONCA S, Kara H, Veziroğlu E, ÇAKIR T, kızıltepe m, Oğuz Kökoğlu E, SENEL A (2023). Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. , 536 - 540. 10.54005/geneltip.1306834 |
| Chicago | Cüce İsa,Yıldızhan Rıdvan,KONCA SİNEM KÜBRA,Kara Hasan,Veziroğlu Enes,ÇAKIR Taha Furkan,kızıltepe melih,Oğuz Kökoğlu Emel,SENEL ABDURRAHMAN SONER Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. (2023): 536 - 540. 10.54005/geneltip.1306834 |
| MLA | Cüce İsa,Yıldızhan Rıdvan,KONCA SİNEM KÜBRA,Kara Hasan,Veziroğlu Enes,ÇAKIR Taha Furkan,kızıltepe melih,Oğuz Kökoğlu Emel,SENEL ABDURRAHMAN SONER Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. , 2023, ss.536 - 540. 10.54005/geneltip.1306834 |
| AMA | Cüce İ,Yıldızhan R,KONCA S,Kara H,Veziroğlu E,ÇAKIR T,kızıltepe m,Oğuz Kökoğlu E,SENEL A Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. . 2023; 536 - 540. 10.54005/geneltip.1306834 |
| Vancouver | Cüce İ,Yıldızhan R,KONCA S,Kara H,Veziroğlu E,ÇAKIR T,kızıltepe m,Oğuz Kökoğlu E,SENEL A Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. . 2023; 536 - 540. 10.54005/geneltip.1306834 |
| IEEE | Cüce İ,Yıldızhan R,KONCA S,Kara H,Veziroğlu E,ÇAKIR T,kızıltepe m,Oğuz Kökoğlu E,SENEL A "Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls." , ss.536 - 540, 2023. 10.54005/geneltip.1306834 |
| ISNAD | Cüce, İsa vd. "Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls". (2023), 536-540. https://doi.org/10.54005/geneltip.1306834 |
| APA | Cüce İ, Yıldızhan R, KONCA S, Kara H, Veziroğlu E, ÇAKIR T, kızıltepe m, Oğuz Kökoğlu E, SENEL A (2023). Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. Genel Tıp Dergisi, 33(5), 536 - 540. 10.54005/geneltip.1306834 |
| Chicago | Cüce İsa,Yıldızhan Rıdvan,KONCA SİNEM KÜBRA,Kara Hasan,Veziroğlu Enes,ÇAKIR Taha Furkan,kızıltepe melih,Oğuz Kökoğlu Emel,SENEL ABDURRAHMAN SONER Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. Genel Tıp Dergisi 33, no.5 (2023): 536 - 540. 10.54005/geneltip.1306834 |
| MLA | Cüce İsa,Yıldızhan Rıdvan,KONCA SİNEM KÜBRA,Kara Hasan,Veziroğlu Enes,ÇAKIR Taha Furkan,kızıltepe melih,Oğuz Kökoğlu Emel,SENEL ABDURRAHMAN SONER Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. Genel Tıp Dergisi, vol.33, no.5, 2023, ss.536 - 540. 10.54005/geneltip.1306834 |
| AMA | Cüce İ,Yıldızhan R,KONCA S,Kara H,Veziroğlu E,ÇAKIR T,kızıltepe m,Oğuz Kökoğlu E,SENEL A Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. Genel Tıp Dergisi. 2023; 33(5): 536 - 540. 10.54005/geneltip.1306834 |
| Vancouver | Cüce İ,Yıldızhan R,KONCA S,Kara H,Veziroğlu E,ÇAKIR T,kızıltepe m,Oğuz Kökoğlu E,SENEL A Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls. Genel Tıp Dergisi. 2023; 33(5): 536 - 540. 10.54005/geneltip.1306834 |
| IEEE | Cüce İ,Yıldızhan R,KONCA S,Kara H,Veziroğlu E,ÇAKIR T,kızıltepe m,Oğuz Kökoğlu E,SENEL A "Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls." Genel Tıp Dergisi, 33, ss.536 - 540, 2023. 10.54005/geneltip.1306834 |
| ISNAD | Cüce, İsa vd. "Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls". Genel Tıp Dergisi 33/5 (2023), 536-540. https://doi.org/10.54005/geneltip.1306834 |
