Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer

kinaci gumuscubuk, yagmur; Hizal, Mutlu; Akinci, Muhammed Bulent; yalcin, bulent; GUMUSCUBUK, Oguzcan; Sendur, Mehmet

doi:10.5505/aot.2023.24654

Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer

Yağmur KINACI GÜMÜŞBIÇAK, (Hacettepe Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Ankara, Türkiye)

Mutlu HIZAL, (Ankara Şehir Hastanesi, Tıbbi Onkoloji Kliniği, Ankara, Türkiye)

Muhammed Bülent AKINCI, (Ankara Şehir Hastanesi, Tıbbi Onkoloji Kliniği, Ankara, Türkiye)

Bülent YALÇIN, (Ankara Şehir Hastanesi, Tıbbi Onkoloji Kliniği, Ankara, Türkiye)

Oğuzcan GÜMÜŞÇUBUK, (Ankara Üniversitesi, Tıp Fakültesi, Geriatrik Tıp Anabilim Dalı, Ankara, Türkiye)

Mehmet Ali Nahit ŞENDUR (Ankara Şehir Hastanesi, Tıbbi Onkoloji Kliniği, Ankara, Türkiye)

ACTA ONCOLOGICA TURCICA

4 1

Yıl: 2023 Cilt: 56 Sayı: 3 Sayfa Aralığı: 198 - 209 Metin Dili: İngilizce DOI: 10.5505/aot.2023.24654 İndeks Tarihi: 18-12-2023

Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer

Öz:

Aim: Questioning and recognizing depression, sleep and sexual dysfunctions in breast cancer patients improves the patients’ quality of life. We aimed to evaluate the effects of adjuvant endocrine treatment and other variables on depression, sleep quality and sexual dysfunction in patients with early-stage breast cancer. Materials and Methods: Our study was performed with the participation of 105 patients who were diagnosed with hormone receptor positive, early stage (stage I-III) breast cancer and at least 3 months followed by the medical oncology outpatient clinic. Sociodemographic form, Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI) and Female Sexual Function Index (FSFI) were used as data collection tools. Results: According to the results obtained in our study, 55.8% patients had depression, 60.6% patients had poor sleep quality, 77.1% had poor sexual function. A tendency to sexual dysfunction was observed in patients with PR positivity and it was found to be statistically significant (P=0.005). There was a strong (p<0.001) correlation between the PSQI and BDI values of the patients. There was no significant relationship between different endocrine therapy agents (tamoxifen/anastrozole/letrozole) in patients with depression, sleep and sexual dysfunction (p> 0.05). Conclusion: In our study, we found a tendency to depression, sleep disturbance, and sexual dysfunction in most patients. It was found that sleep disorders and sexual dysfunction increased in patients with depression. It was also statistically significant that hormone receptor status could affect sexual function. Therefore, symptoms related to depression, sleep and sexual problems should be questioned in patients followed up with a diagnosis of breast cancer.

Anahtar Kelime:

Hormon Reseptör Pozitif Erken Evre Meme Kanserinde Adjuvan Hormonal Tedavinin Depresyon, Uyku Kalitesi ve Cinsel Fonksiyon Üzerine Etkinliğinin Araştırılması

Öz:

Giriş ve Amaç: Meme kanseri hastalarında depresyon, uyku ve cinsel işlev bozukluklarını sorgulamak ve tanımak hastaların yaşam kalitesini iyileştirmektedir. Erken evre meme kanserli hastalarda adjuvan endokrin tedavisi ve diğer değişkenlerin depresyon, uyku kalitesi ve cinsel işlev bozukluğu üzerine etkilerini değerlendirmeyi amaçladık. Yöntem ve Gereçler: Çalışmamız, hormon reseptörü pozitif, erken evre (evre I-III) meme kanseri tanısı almış ve medikal onkoloji polikliniğinde en az 3 ay takip edilen 105 hastanın katılımıyla gerçekleştirildi. Veri toplama aracı olarak sosyodemografik form, Beck Depresyon Envanteri (BDI), Pittsburgh Uyku Kalitesi İndeksi (PSQI) ve Kadın Cinsel İşlev İndeksi (FSFI) kullanıldı. Bulgular: Çalışmamızda elde ettiğimiz sonuçlara göre hastaların %55.8'inde depresyon, %60,6'sında kötü uyku kalitesi, %77.1'inde cinsel işlev bozukluğu saptandı. PR pozitif olan hastalarda cinsel işlev bozukluğuna eğilim gözlendi ve istatistiksel olarak anlamlı bulundu (P=0,005). Hastaların PUKİ ve BDI değerleri arasında güçlü (p<0,001) bir korelasyon vardı. Depresyon, uyku ve cinsel işlev bozukluğu olan hastalarda farklı endokrin tedavi ajanları (tamoksifen/anastrozol/letrozol) arasında ise anlamlı bir ilişki yoktu (p> 0.05). Tartışma ve Sonuç: Çalışmamızda çoğu hastada depresyon, uyku bozukluğu ve cinsel işlev bozukluğuna eğilim saptadık. Bazı sosyodemografik özelliklerin ve hormon reseptör durumunun cinsel işlevselliği etkileyebileceği ortaya çıktı. Bu nedenle meme kanseri tanısı ile takip edilen hastalarda bu belirtilerin sorgulanması ve değerlendirilmesi önemlidir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	kinaci gumuscubuk y, Hizal M, Akinci M, yalcin b, GUMUSCUBUK O, Sendur M (2023). Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. , 198 - 209. 10.5505/aot.2023.24654
Chicago	kinaci gumuscubuk yagmur,Hizal Mutlu,Akinci Muhammed Bulent,yalcin bulent,GUMUSCUBUK Oguzcan,Sendur Mehmet Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. (2023): 198 - 209. 10.5505/aot.2023.24654
MLA	kinaci gumuscubuk yagmur,Hizal Mutlu,Akinci Muhammed Bulent,yalcin bulent,GUMUSCUBUK Oguzcan,Sendur Mehmet Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. , 2023, ss.198 - 209. 10.5505/aot.2023.24654
AMA	kinaci gumuscubuk y,Hizal M,Akinci M,yalcin b,GUMUSCUBUK O,Sendur M Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. . 2023; 198 - 209. 10.5505/aot.2023.24654
Vancouver	kinaci gumuscubuk y,Hizal M,Akinci M,yalcin b,GUMUSCUBUK O,Sendur M Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. . 2023; 198 - 209. 10.5505/aot.2023.24654
IEEE	kinaci gumuscubuk y,Hizal M,Akinci M,yalcin b,GUMUSCUBUK O,Sendur M "Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer." , ss.198 - 209, 2023. 10.5505/aot.2023.24654
ISNAD	kinaci gumuscubuk, yagmur vd. "Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer". (2023), 198-209. https://doi.org/10.5505/aot.2023.24654

APA	kinaci gumuscubuk y, Hizal M, Akinci M, yalcin b, GUMUSCUBUK O, Sendur M (2023). Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. ACTA ONCOLOGICA TURCICA, 56(3), 198 - 209. 10.5505/aot.2023.24654
Chicago	kinaci gumuscubuk yagmur,Hizal Mutlu,Akinci Muhammed Bulent,yalcin bulent,GUMUSCUBUK Oguzcan,Sendur Mehmet Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. ACTA ONCOLOGICA TURCICA 56, no.3 (2023): 198 - 209. 10.5505/aot.2023.24654
MLA	kinaci gumuscubuk yagmur,Hizal Mutlu,Akinci Muhammed Bulent,yalcin bulent,GUMUSCUBUK Oguzcan,Sendur Mehmet Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. ACTA ONCOLOGICA TURCICA, vol.56, no.3, 2023, ss.198 - 209. 10.5505/aot.2023.24654
AMA	kinaci gumuscubuk y,Hizal M,Akinci M,yalcin b,GUMUSCUBUK O,Sendur M Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. ACTA ONCOLOGICA TURCICA. 2023; 56(3): 198 - 209. 10.5505/aot.2023.24654
Vancouver	kinaci gumuscubuk y,Hizal M,Akinci M,yalcin b,GUMUSCUBUK O,Sendur M Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer. ACTA ONCOLOGICA TURCICA. 2023; 56(3): 198 - 209. 10.5505/aot.2023.24654
IEEE	kinaci gumuscubuk y,Hizal M,Akinci M,yalcin b,GUMUSCUBUK O,Sendur M "Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer." ACTA ONCOLOGICA TURCICA, 56, ss.198 - 209, 2023. 10.5505/aot.2023.24654
ISNAD	kinaci gumuscubuk, yagmur vd. "Investigation of the Effect of Adjuvant Endocrine Treatment on Depression, Sleep Quality and Sexual Function in Hormone Receptor-Positive Early-Stage Breast Cancer". ACTA ONCOLOGICA TURCICA 56/3 (2023), 198-209. https://doi.org/10.5505/aot.2023.24654