Expression Profiles Of PTEN And POGZ Genes In Patients With Autism

(TOPALOĞLU) TEZCAN, Tuğba; Sener, Elif Funda; Demirci, Esra; Sahin, Nilfer; Hamurcu, Zuhal; Öztop, Didem Behice

doi:10.30565/medalanya.1148353

Expression Profiles Of PTEN And POGZ Genes In Patients With Autism

Tuğba TEZCAN, (Kapadokya Üniversitesi, Kapadokya Meslek Yüksekokulu, Tıbbi Laboratuvar Programı, Nevşehir, Türkiye)

Elif Funda ŞENER, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Kayseri, Türkiye)

Esra DEMİRCİ, (Erciyes Üniversitesi, Tıp Fakültesi, Çocuk Psikiyatrisi Anabilim Dalı, Kayseri, Türkiye)

Nilfer ŞAHİN, (Muğla Sıtkı Kocaman Üniversitesi, Tıp Fakültesi, Çocuk Psikiyatrisi Anabilim Dalı, Muğla, Türkiye)

Zuhal HAMURCU, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Kayseri, Türkiye)

Didem ÖZTOP (Ankara Üniversitesi, Tıp Fakültesi, Çocuk Psikiyatrisi Anabilim Dalı, Ankara, Türkiye)

Acta Medica Alanya

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Yıl: 2022 Cilt: 6 Sayı: 3 Sayfa Aralığı: 250 - 255 Metin Dili: İngilizce DOI: 10.30565/medalanya.1148353 İndeks Tarihi: 04-01-2024

Expression Profiles Of PTEN And POGZ Genes In Patients With Autism

Öz:

Aim: Autism spectrum disorder (ASD), a group of heterogeneous neurodevelopmental disorders, is characterized by complex behavioral phenotypes. Despite extensive studies over many years, the causes of ASD are still unknown. PTEN and POGZ genes are studied as candidate genes that may be responsible for the ASD phenotype. We aimed to investigate the expression levels of PTEN and POGZ genes in autistic patients.Methods: Gene expressions of PTEN and POGZ were investigated in 50 ASD patients and 50 age and gender matched healthy controls. This study was conducted in the Erciyes University Genome and Stem Cell Center (GENKOK).Results: POGZ gene expression was increased in patients compared to controls. According to gender, the expression results of the autistic male patients were significant. PTEN mRNA expression was not statistically significant but found to be lower in patients than in controls. The relationship between the expression of these genes and cognitive deficits was not significant.Conclusion: We recommend investigating other possible candidate genes in larger cohorts and comparing the results with different additional cilinical findings in ASD.

Anahtar Kelime: Autism Autism Spectrum Disorders PTEN POGZ Expression

Otizmli Hastalarda PTEN Ve POGZ Genlerinin Ekspresyon Profilleri

Öz:

Amaç: Otizm spektrum bozukluğu (OSB), karmaşık davranışsal fenotiplerle karakterize, heterojen bir grup nörogelişimsel bozukluktur. Uzun yıllar boyunca yapılan kapsamlı çalışmalara rağmen, OSB'nin nedenleri hala bilinmemektedir. PTEN ve POGZ genleri, OSB fenotipinden sorumlu olabilecek aday genler olarak gösterilmiştir. Otistik hastalarda PTEN ve POGZ genlerinin ekspresyon düzeylerini araştırmayı amaçladık.Yöntem: OSB tanılı 50 hastada ve yaş-cinsiyet uyumlu 50 sağlıklı kontrolde PTEN ve POGZ gen ekspresyonları araştırıldı. Bu çalışma Erciyes Üniversitesi Genom ve Kök Hücre Merkezi'nde (GENKÖK) yapılmıştır.Bulgular: POGZ geninin hastalarda kontrollere göre daha fazla eksprese olduğu ve otistik erkek hastalarda bu genin ekspresyonunun anlamlı olduğu bulundu. PTEN gen ekspresyonu istatistiksel olarak anlamlı değildi ancak hastalarda kontrollere göre daha düşük bulundu. Bu genlerin ekspresyonu ile bilişsel gerilik arasındaki ilişki ise anlamlı değildi.Sonuç: Daha büyük hasta grupları ile diğer olası aday genlerin araştırılmasını ve sonuçların farklı ek klinik belirtilerle hastalarda karşılaştırılmasını önermekteyiz.

Anahtar Kelime: Otizm Otizm Spektrum Bozuklukları PTEN POGZ Ekspresyon

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	(TOPALOĞLU) TEZCAN T, Sener E, Demirci E, Sahin N, Hamurcu Z, Öztop D (2022). Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. , 250 - 255. 10.30565/medalanya.1148353
Chicago	(TOPALOĞLU) TEZCAN Tuğba,Sener Elif Funda,Demirci Esra,Sahin Nilfer,Hamurcu Zuhal,Öztop Didem Behice Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. (2022): 250 - 255. 10.30565/medalanya.1148353
MLA	(TOPALOĞLU) TEZCAN Tuğba,Sener Elif Funda,Demirci Esra,Sahin Nilfer,Hamurcu Zuhal,Öztop Didem Behice Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. , 2022, ss.250 - 255. 10.30565/medalanya.1148353
AMA	(TOPALOĞLU) TEZCAN T,Sener E,Demirci E,Sahin N,Hamurcu Z,Öztop D Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. . 2022; 250 - 255. 10.30565/medalanya.1148353
Vancouver	(TOPALOĞLU) TEZCAN T,Sener E,Demirci E,Sahin N,Hamurcu Z,Öztop D Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. . 2022; 250 - 255. 10.30565/medalanya.1148353
IEEE	(TOPALOĞLU) TEZCAN T,Sener E,Demirci E,Sahin N,Hamurcu Z,Öztop D "Expression Profiles Of PTEN And POGZ Genes In Patients With Autism." , ss.250 - 255, 2022. 10.30565/medalanya.1148353
ISNAD	(TOPALOĞLU) TEZCAN, Tuğba vd. "Expression Profiles Of PTEN And POGZ Genes In Patients With Autism". (2022), 250-255. https://doi.org/10.30565/medalanya.1148353

APA	(TOPALOĞLU) TEZCAN T, Sener E, Demirci E, Sahin N, Hamurcu Z, Öztop D (2022). Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. Acta Medica Alanya, 6(3), 250 - 255. 10.30565/medalanya.1148353
Chicago	(TOPALOĞLU) TEZCAN Tuğba,Sener Elif Funda,Demirci Esra,Sahin Nilfer,Hamurcu Zuhal,Öztop Didem Behice Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. Acta Medica Alanya 6, no.3 (2022): 250 - 255. 10.30565/medalanya.1148353
MLA	(TOPALOĞLU) TEZCAN Tuğba,Sener Elif Funda,Demirci Esra,Sahin Nilfer,Hamurcu Zuhal,Öztop Didem Behice Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. Acta Medica Alanya, vol.6, no.3, 2022, ss.250 - 255. 10.30565/medalanya.1148353
AMA	(TOPALOĞLU) TEZCAN T,Sener E,Demirci E,Sahin N,Hamurcu Z,Öztop D Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. Acta Medica Alanya. 2022; 6(3): 250 - 255. 10.30565/medalanya.1148353
Vancouver	(TOPALOĞLU) TEZCAN T,Sener E,Demirci E,Sahin N,Hamurcu Z,Öztop D Expression Profiles Of PTEN And POGZ Genes In Patients With Autism. Acta Medica Alanya. 2022; 6(3): 250 - 255. 10.30565/medalanya.1148353
IEEE	(TOPALOĞLU) TEZCAN T,Sener E,Demirci E,Sahin N,Hamurcu Z,Öztop D "Expression Profiles Of PTEN And POGZ Genes In Patients With Autism." Acta Medica Alanya, 6, ss.250 - 255, 2022. 10.30565/medalanya.1148353
ISNAD	(TOPALOĞLU) TEZCAN, Tuğba vd. "Expression Profiles Of PTEN And POGZ Genes In Patients With Autism". Acta Medica Alanya 6/3 (2022), 250-255. https://doi.org/10.30565/medalanya.1148353