The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme

Fatma Sayan Poyraz, (Yıldız Teknik Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul, Türkiye)
Zeynep Yagmur Karagulleoglu, (Yıldız Teknik Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul, Türkiye)
Banu Mansuroglu (Yıldız Teknik Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul, Türkiye)
Frontiers in Life Sciences and Related Technologies (Online)
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Yıl: 2023 Cilt: 4 Sayı: 3 Sayfa Aralığı: 125 - 131 Metin Dili: İngilizce DOI: 10.51753/flsrt.1287232 İndeks Tarihi: 05-01-2024

The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme

Öz:
Cancer is a disease that occurs due to irregular growth and proliferation of body cells and can be caused by many factors. One of these factors is carbonic anhydrase 9 (CAIX). While its expression is high in malignant cells, it is a molecule whose presence is difficult to detect in healthy tissues. Glioblastoma multiforme (GBM) is one of the fast-spreading brain cancers, and unlike healthy tissues, overexpressed CAIX in its cell receptors. Indisulam, one of the new-generation drug candidates for the treatment of solid tumours, is a type of CAIX inhibitor that affects cell division progression in human tumour cells. Similarly, it is known that coumarin, as one of the new-generation drugs in cancer treatment, is used together with chemotherapy. In this study, combined treatment of indisulam and coumarin was investigated on glioblastoma multiforme cells to evaluate their cytotoxicity, cell migration and antiproliferative effects. The effects of combined treatment on cell migration and proliferation were investigated with the IC50 values determined after the cytotoxicity test. As a result of the wound healing assay, it was determined that the control cells were closed by 69.6%, while the combined treatment closed the wound by 32% and seriously prevented cell migration. The percentage of proliferative cell nuclear antigen (PCNA) positive cells decreased significantly after combined treatment, cell proliferation was 93% in the control group and 77% in the combined treatment group.
Anahtar Kelime: Cancer carbonic anhydrase IX coumarin indisulam glioblastoma

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Poyraz F, Karagülleoğlu Z, Mansuroğlu B (2023). The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. , 125 - 131. 10.51753/flsrt.1287232
Chicago Poyraz Fatma Şayan,Karagülleoğlu Zeynep Yağmur,Mansuroğlu Banu The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. (2023): 125 - 131. 10.51753/flsrt.1287232
MLA Poyraz Fatma Şayan,Karagülleoğlu Zeynep Yağmur,Mansuroğlu Banu The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. , 2023, ss.125 - 131. 10.51753/flsrt.1287232
AMA Poyraz F,Karagülleoğlu Z,Mansuroğlu B The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. . 2023; 125 - 131. 10.51753/flsrt.1287232
Vancouver Poyraz F,Karagülleoğlu Z,Mansuroğlu B The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. . 2023; 125 - 131. 10.51753/flsrt.1287232
IEEE Poyraz F,Karagülleoğlu Z,Mansuroğlu B "The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme." , ss.125 - 131, 2023. 10.51753/flsrt.1287232
ISNAD Poyraz, Fatma Şayan vd. "The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme". (2023), 125-131. https://doi.org/10.51753/flsrt.1287232
APA Poyraz F, Karagülleoğlu Z, Mansuroğlu B (2023). The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. Frontiers in Life Sciences and Related Technologies (Online), 4(3), 125 - 131. 10.51753/flsrt.1287232
Chicago Poyraz Fatma Şayan,Karagülleoğlu Zeynep Yağmur,Mansuroğlu Banu The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. Frontiers in Life Sciences and Related Technologies (Online) 4, no.3 (2023): 125 - 131. 10.51753/flsrt.1287232
MLA Poyraz Fatma Şayan,Karagülleoğlu Zeynep Yağmur,Mansuroğlu Banu The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. Frontiers in Life Sciences and Related Technologies (Online), vol.4, no.3, 2023, ss.125 - 131. 10.51753/flsrt.1287232
AMA Poyraz F,Karagülleoğlu Z,Mansuroğlu B The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. Frontiers in Life Sciences and Related Technologies (Online). 2023; 4(3): 125 - 131. 10.51753/flsrt.1287232
Vancouver Poyraz F,Karagülleoğlu Z,Mansuroğlu B The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme. Frontiers in Life Sciences and Related Technologies (Online). 2023; 4(3): 125 - 131. 10.51753/flsrt.1287232
IEEE Poyraz F,Karagülleoğlu Z,Mansuroğlu B "The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme." Frontiers in Life Sciences and Related Technologies (Online), 4, ss.125 - 131, 2023. 10.51753/flsrt.1287232
ISNAD Poyraz, Fatma Şayan vd. "The inhibitory effect of indisulam-coumarin combined therapy on glioblastoma multiforme". Frontiers in Life Sciences and Related Technologies (Online) 4/3 (2023), 125-131. https://doi.org/10.51753/flsrt.1287232
Sayfa Oluşturulma Tarihi
24-04-2024 10:20

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