Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications

Kerim Emre ÖKSÜZ (Sivas Cumhuriyet Üniversitesi, Metalurji ve Malzeme Mühendisliği Bölümü, Sivas, Türkiye)
Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi
1 0
Yıl: 2023 Cilt: 4 Sayı: 2 Sayfa Aralığı: 65 - 75 Metin Dili: İngilizce DOI: 10.53501/rteufemud.1293580 İndeks Tarihi: 05-01-2024

Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications

Öz:
This paper focuses on the development of high-quality bioceramic foams for the treatment of hard tissue defects, which are a widespread clinical problem worldwide. In this experimental study, α-alumina (Al2O3) ceramics with boron carbide (B4C) additives, intended for use in biomedical applications, were produced and characterized as highly porous using the replication method. The thermal properties of open-pore polyurethane sponges, with a pore size of 20 ppi, used as an economical polymer model material, were determined by thermo-gravimetric (TGA) and derivative thermogravimetric analysis (DTG). Ceramic foams based on Al2O3, with varying B4C ratios, were obtained by high-temperature sintering and were thoroughly examined using high-resolution field emission gun scanning electron microscopy (FEG-SEM) for homogeneity, high porosity, and interconnected pore microstructure. X-ray diffraction (XRD) analyses confirmed the presence of B4C within the structure and phase changes. The compressive strength values of sintered ceramic foams containing 0%, 3%, and 5% B4C by weight were measured as 1.92 MPa, 2.05 MPa, and 2.38 MPa, respectively. In vitro tests were performed to evaluate the biological response that biomaterials intended for use in living environments would produce. Satisfactory results were obtained from cell viability experiments, demonstrating that the addition of B4C to Al2O3-based ceramic foams supports cell proliferation, which is an important advantage in hard tissue defect treatment.
Anahtar Kelime: Al2O3 B4C Ceramic foam In vitro Macro porous Microstructure

Sert Doku Uygulamaları için Makro Gözenekli Alüminyum Oksit-Bor Karbür Seramikleri

Öz:
Bu çalışma, dünya çapında yaygın bir klinik problem olan sert doku defektlerinin tedavisi için yüksek kaliteli biyoseramik köpüklerin geliştirilmesine odaklanmaktadır. Bu deneysel çalışmada, biyomedikal alanlarda kullanılması hedeflenen bor karbür (B4C) ilaveli α-alüminyum oksit (Al2O3) seramikler replika yöntemi ile yüksek gözenekli olarak üretilmiş ve karakterize edilmiştir. Ekonomik polimer model malzeme olarak kullanılan açık gözenekli, 20 ppi gözenek boyutunda poliüretan süngerlerin termogravimetrik (TGA) ve derivatif termogravimetrik analizleri (DTG) ile termal özellikleri belirlenmiştir. Yüksek sıcaklıkta sinterlenerek elde edilen, farklı B4C oranları içeren Al2O3 esaslı seramik köpükler homojen, yüksek gözenekli ve birleştirici gözenek mikroyapısında olduğu yüksek alan emisyon tabancalı taramalı elektron mikroskobu (FEG-SEM) ile detaylı olarak incelenmiştir. X-ışınları (XRD) analizleri ile B4C’nin yapı içerisinde varlığı ve faz değişimleri doğrulanmıştır. Yapısında ağırlıkça %0, %3 ve %5 B4C içeren sinterlenmiş seramik köpüklerin basma mukavemeti değerleri sırasıyla 1,92 MPa, 2,05 MPa ve 2,38 MPa olarak ölçülmüştür. Canlı ortamlarda kullanılacak biyomalzemelerin oluşturacağı biyolojik cevabın önceden değerlendirilmesi amacıyla yapılan in vitro testlerde tatmin edici sonuçlar elde edilmiştir. Hücre canlılığı deneyleri, Al2O3 esaslı seramik köpüklere B4C ilavesinin sert doku defektlerinde önemli bir avantaj olan hücre proliferasyonunu desteklediğini göstermiştir.
Anahtar Kelime: Al2O3 B4C Seramik köpük In vitro Makro gözenek Mikroyapı

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ÖKSÜZ K (2023). Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. , 65 - 75. 10.53501/rteufemud.1293580
Chicago ÖKSÜZ Kerim Emre Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. (2023): 65 - 75. 10.53501/rteufemud.1293580
MLA ÖKSÜZ Kerim Emre Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. , 2023, ss.65 - 75. 10.53501/rteufemud.1293580
AMA ÖKSÜZ K Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. . 2023; 65 - 75. 10.53501/rteufemud.1293580
Vancouver ÖKSÜZ K Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. . 2023; 65 - 75. 10.53501/rteufemud.1293580
IEEE ÖKSÜZ K "Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications." , ss.65 - 75, 2023. 10.53501/rteufemud.1293580
ISNAD ÖKSÜZ, Kerim Emre. "Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications". (2023), 65-75. https://doi.org/10.53501/rteufemud.1293580
APA ÖKSÜZ K (2023). Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, 4(2), 65 - 75. 10.53501/rteufemud.1293580
Chicago ÖKSÜZ Kerim Emre Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi 4, no.2 (2023): 65 - 75. 10.53501/rteufemud.1293580
MLA ÖKSÜZ Kerim Emre Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, vol.4, no.2, 2023, ss.65 - 75. 10.53501/rteufemud.1293580
AMA ÖKSÜZ K Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi. 2023; 4(2): 65 - 75. 10.53501/rteufemud.1293580
Vancouver ÖKSÜZ K Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications. Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi. 2023; 4(2): 65 - 75. 10.53501/rteufemud.1293580
IEEE ÖKSÜZ K "Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications." Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, 4, ss.65 - 75, 2023. 10.53501/rteufemud.1293580
ISNAD ÖKSÜZ, Kerim Emre. "Macro-Porous Aluminum Oxide-Boron Carbide Ceramics for Hard Tissue Applications". Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi 4/2 (2023), 65-75. https://doi.org/10.53501/rteufemud.1293580
Sayfa Oluşturulma Tarihi
24-04-2024 10:21

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