Yıl: 2023 Cilt: 13 Sayı: 4 Sayfa Aralığı: 776 - 781 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.1199615 İndeks Tarihi: 07-01-2024

N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats

Öz:
Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is the precursor of glutathione, the most important endogenous antioxidant molecule and is known for its effective antioxidant and anti-inflammatory properties. Although NAC is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-FU has not been demonstrated to date. It was therefore aimed to investigate whether NAC is therapeutic against 5-FU-induced ovotoxicity in this study for the first time. Methods: Rats were first exposed to a single dose of 5-FU (100 mg/kg) and then treated with NAC (10 and 20 mg/kg) for three days. The oxidative stress, inflammation and apoptosis markers in ovarian tissues were also determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. Results: It was revealed that the levels of oxidative stress, inflammation and apoptosis biomarkers in ovarian tissue increased by 5-FU administration (p<.005). Treatments with NAC significantly restored these damages dose-dependently (p<.005). Moreover, these biochemical findings were confirmed by histological examination. Conclusion: NAC can be considered as a potential therapeutic molecule against 5-FU-induced reproductive toxicity, as it can abolish the ovarian toxicity caused by 5-FU by reducing oxidative stress, inflammation and apoptosis.
Anahtar Kelime: 5-Fluorouracil Apoptosis Inflammation N-acetylcysteine Oxidative stress Ovotoxicity

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ayazoglu demir e, Menteşe A, Küçük H, TÜRKMEN ALEMDAR N, Demir S, Aliyazıcıoğlu Y (2023). N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. , 776 - 781. 10.33808/clinexphealthsci.1199615
Chicago ayazoglu demir elif,Menteşe Ahmet,Küçük Hatice,TÜRKMEN ALEMDAR NİHAL,Demir Selim,Aliyazıcıoğlu Yüksel N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. (2023): 776 - 781. 10.33808/clinexphealthsci.1199615
MLA ayazoglu demir elif,Menteşe Ahmet,Küçük Hatice,TÜRKMEN ALEMDAR NİHAL,Demir Selim,Aliyazıcıoğlu Yüksel N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. , 2023, ss.776 - 781. 10.33808/clinexphealthsci.1199615
AMA ayazoglu demir e,Menteşe A,Küçük H,TÜRKMEN ALEMDAR N,Demir S,Aliyazıcıoğlu Y N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. . 2023; 776 - 781. 10.33808/clinexphealthsci.1199615
Vancouver ayazoglu demir e,Menteşe A,Küçük H,TÜRKMEN ALEMDAR N,Demir S,Aliyazıcıoğlu Y N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. . 2023; 776 - 781. 10.33808/clinexphealthsci.1199615
IEEE ayazoglu demir e,Menteşe A,Küçük H,TÜRKMEN ALEMDAR N,Demir S,Aliyazıcıoğlu Y "N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats." , ss.776 - 781, 2023. 10.33808/clinexphealthsci.1199615
ISNAD ayazoglu demir, elif vd. "N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats". (2023), 776-781. https://doi.org/10.33808/clinexphealthsci.1199615
APA ayazoglu demir e, Menteşe A, Küçük H, TÜRKMEN ALEMDAR N, Demir S, Aliyazıcıoğlu Y (2023). N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences, 13(4), 776 - 781. 10.33808/clinexphealthsci.1199615
Chicago ayazoglu demir elif,Menteşe Ahmet,Küçük Hatice,TÜRKMEN ALEMDAR NİHAL,Demir Selim,Aliyazıcıoğlu Yüksel N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences 13, no.4 (2023): 776 - 781. 10.33808/clinexphealthsci.1199615
MLA ayazoglu demir elif,Menteşe Ahmet,Küçük Hatice,TÜRKMEN ALEMDAR NİHAL,Demir Selim,Aliyazıcıoğlu Yüksel N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences, vol.13, no.4, 2023, ss.776 - 781. 10.33808/clinexphealthsci.1199615
AMA ayazoglu demir e,Menteşe A,Küçük H,TÜRKMEN ALEMDAR N,Demir S,Aliyazıcıoğlu Y N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences. 2023; 13(4): 776 - 781. 10.33808/clinexphealthsci.1199615
Vancouver ayazoglu demir e,Menteşe A,Küçük H,TÜRKMEN ALEMDAR N,Demir S,Aliyazıcıoğlu Y N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences. 2023; 13(4): 776 - 781. 10.33808/clinexphealthsci.1199615
IEEE ayazoglu demir e,Menteşe A,Küçük H,TÜRKMEN ALEMDAR N,Demir S,Aliyazıcıoğlu Y "N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats." Clinical and Experimental Health Sciences, 13, ss.776 - 781, 2023. 10.33808/clinexphealthsci.1199615
ISNAD ayazoglu demir, elif vd. "N-Acetylcysteine Ameliorates 5-Fluorouracil Induced Ovarian Injury in Rats". Clinical and Experimental Health Sciences 13/4 (2023), 776-781. https://doi.org/10.33808/clinexphealthsci.1199615