Objective: To evaluate the shear bond strength (SBS) of yttrium-stabilized tetragonal zirconia polycrystals bonded to titanium alloys via different surface treatment methods using four different cements. Methods: Eighty titanium and monolithic zirconia discs were prepared with computer-aided design/manufacturing (CAD/CAM) technology. All titanium discs and 40 of monolithic zirconia discs were polished by using silicon carbide paper and sandblasted with 50 μm aluminum oxide (Al2O3). Tribochemical silica coating was applied to remaining 40 monolithic zirconia discs. The monolithic zirconia discs were divided into eight groups after surface treatment (n=10). Titanium discs were cemented using conventional glass ionomer cement (GIC), resin-modified GIC, self- adhesive resin cement, and dual-cure resin cement. The SBS test was performed using a universal testing machine. The failure patterns were examined by using a scanning electron microscope (SEM). Data were statistically analyzed with one-way analysis of variance (ANOVA), two-way ANOVA and Tukey’s test (α<.05). Results: The SBS values differed according to the surface treatment methods and cements used (p<.001). The highest and lowest SBS values were measured in the tribochemical-silica-coated G-CEM ONE (34.77±5.53 MPa) and Al2O3 sandblasted GC Fuji I (3.30±0.77 MPa) cement groups, respectively. Failure analysis revealed that 41.25%, 31.75% and 25% of the failures were cohesive, adhesive, and combined failures, respectively. Conclusion: The SBS values between the monolithic zirconia and titanium alloy were significantly higher in the resin cement groups containing 10-methacryloyloxydecyl dihydrogen thiophosphate and 10-methacryloyloxydecyl dihydrogen phosphate (p<.05). While adhesive and combined failures were observed at high SBS values, cohesive failures were detected as the bonding values decreased.