Yıl: 2023 Cilt: 53 Sayı: 6 Sayfa Aralığı: 1690 - 1696 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5737 İndeks Tarihi: 17-01-2024

The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders

Öz:
Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from the patients and centrifuged, and stored at –80 °C until analyzed. All samples were examined for Interleukin-6 (IL-6), Malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) concentrations. Results: There was no significant difference between the groups regarding median values of 8-OHdG, IL-6, and MDA (p > 0.05). When the relationship between serum and salivary 8-OHdG, IL-6, and MDA levels in all subjects was evaluated, there was a strong positive correlation between the levels of 8-OHdG and IL-6 in the serum (r = 0.752, p <0.001). In the study group, when the relationship between pain levels and serum and saliva 8-OHdG, IL-6, and MDA levels was assessed, a positive and strong correlation was found between the levels of 8-OHdG and IL-6 in serum. Conclusion: Although the strong correlation between pain scores and serum 8-OHdG and MDA levels supports the hypothesis that inflammation and OS mechanisms may be interrelated, according to the results of the study, inflammatory and OS markers in patients with TMD were not different from healthy individuals.
Anahtar Kelime: Temporomandibular disorders oxidative stress inflammation

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Kazan D, BAŞ B, Aksoy A, Atmaca E (2023). The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. , 1690 - 1696. 10.55730/1300-0144.5737
Chicago Kazan Dilara,BAŞ BURCU,Aksoy Abdurrahman,Atmaca Enes The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. (2023): 1690 - 1696. 10.55730/1300-0144.5737
MLA Kazan Dilara,BAŞ BURCU,Aksoy Abdurrahman,Atmaca Enes The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. , 2023, ss.1690 - 1696. 10.55730/1300-0144.5737
AMA Kazan D,BAŞ B,Aksoy A,Atmaca E The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. . 2023; 1690 - 1696. 10.55730/1300-0144.5737
Vancouver Kazan D,BAŞ B,Aksoy A,Atmaca E The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. . 2023; 1690 - 1696. 10.55730/1300-0144.5737
IEEE Kazan D,BAŞ B,Aksoy A,Atmaca E "The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders." , ss.1690 - 1696, 2023. 10.55730/1300-0144.5737
ISNAD Kazan, Dilara vd. "The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders". (2023), 1690-1696. https://doi.org/10.55730/1300-0144.5737
APA Kazan D, BAŞ B, Aksoy A, Atmaca E (2023). The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. Turkish Journal of Medical Sciences, 53(6), 1690 - 1696. 10.55730/1300-0144.5737
Chicago Kazan Dilara,BAŞ BURCU,Aksoy Abdurrahman,Atmaca Enes The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. Turkish Journal of Medical Sciences 53, no.6 (2023): 1690 - 1696. 10.55730/1300-0144.5737
MLA Kazan Dilara,BAŞ BURCU,Aksoy Abdurrahman,Atmaca Enes The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. Turkish Journal of Medical Sciences, vol.53, no.6, 2023, ss.1690 - 1696. 10.55730/1300-0144.5737
AMA Kazan D,BAŞ B,Aksoy A,Atmaca E The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. Turkish Journal of Medical Sciences. 2023; 53(6): 1690 - 1696. 10.55730/1300-0144.5737
Vancouver Kazan D,BAŞ B,Aksoy A,Atmaca E The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders. Turkish Journal of Medical Sciences. 2023; 53(6): 1690 - 1696. 10.55730/1300-0144.5737
IEEE Kazan D,BAŞ B,Aksoy A,Atmaca E "The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders." Turkish Journal of Medical Sciences, 53, ss.1690 - 1696, 2023. 10.55730/1300-0144.5737
ISNAD Kazan, Dilara vd. "The evaluation of oxidative stress and inflammation markers in serum and saliva of the patients with temporomandibular disorders". Turkish Journal of Medical Sciences 53/6 (2023), 1690-1696. https://doi.org/10.55730/1300-0144.5737