Yıl: 2023 Cilt: 47 Sayı: 6 Sayfa Aralığı: 584 - 587 Metin Dili: İngilizce İndeks Tarihi: 17-01-2024

Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye

Öz:
Genetic diseases play an increasingly important role in cattle breeding as breeding technologies such as artificial insemination has an inborn risk of disseminating deleterious genes, especially from high merit breeding sires. Cholesterol deficiency (CD) is a metabolic disorder first recognized in Holstein cattle in 2015. The condition is characterized by chronic diarrhea and unthriftiness in calves being homozygous for the defective allele. The prevalence of carriers of CD in Turkish cattle is at present unknown and therefore 700 heifers and cows of different breeds, including 300 Holsteins were genotyped. Of the tested Holsteins, 2.0% turned out to be carriers of CD thus showing that the defective allele for CD is actually present in Turkish Holstein cattle. The carrier prevalence was between 0% and 4.0% in 4 different Holstein herds. Carriers were not found in other breeds tested, which included native Turkish cattle breeds. To avoid the birth of Holstein calves that will develop clinical signs of CD, sires should be tested for CD, and only homozygous normal individuals should be used for breeding.
Anahtar Kelime: Turkish native cattle Holstein Simmental cholesterol deficiency PCR

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Charlier C, Agerholm JS, Coppieters W, Karlskov-Mortensen P, Li W et al. A deletion in the bovine FANCI gene compromises fertility by causing fetal death and brachyspina. PLoS One 2012; 7 (8): e43085. https://doi.org/10.1371/journal.pone.0043085
  • 2. Casas E, Kehrli ME. A Review of Selected Genes with Known Effects on Performance and Health of Cattle. Frontiers in Veterinary Science 2016; 3: 113. https://doi.org/10.3389/ fvets.2016.00113
  • 3. Kipp S, Segelke D, Schierenbeck S, Reinhardt F, Reents R et al. Identification of a haplotype associated with cholesterol deficiency and increased juvenile mortality in Holstein cattle. Journal of Dairy Science 2016; 99: 1-17.https://doi.org/10.3168/ jds.2016-11118
  • 4. Gross JJ, Schwinn AC, Schmitz Hsu F, Menzi F, Drögemüller C et al. Rapid communication: cholesterol deficiency–associated APOB mutation impacts lipid metabolism in Holstein calves and breeding bulls. Journal of Animal Science 2016; 94: 1761- 6. https://doi.org/10.2527/jas.2016-0439
  • 5. Häfliger IM, Hofstetter S, Mock T, Stettler MH, Meylan M et al. APOB-associated cholesterol deficiency in Holstein cattle is not a simple recessive disease. Animal Genetics 2019; 50 (4): 372- 375. https://doi.org/10.1111/age.12801
  • 6. Menzi F, Besuchet Schmutz N, Fragnière M, Hofstetter S, Jagannathan V et al. A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle. Animal Genetics 2016; 47: 253-257. https://doi.org/10.1111/age.12410
  • 7. Schütz E, Wehrhahn C, Wanjek M, Bortfeld R, Wemheuer WE et al. The Holstein Friesian lethal haplotype 5 (HH5) results from a complete deletion of TBF1M and cholesterol deficiency (CDH) from an ERV (LTR) insertion into the coding region of APOB. PLoS One 2016; 11: e0154602. https://doi.org/10.1371/ journal.pone.0154602
  • 8. VanRaden P, Null D. Holstein haplotype for cholesterol deficiency (HCD). Canadian Dairy Network Online Database 2015; Accessed 16th July. 2023.
  • 9. Meydan H, Yıldız MA, Agerholm JS. Screening for bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, complex vertebral malformation, bovine citrullinaemia, and factor XI deficiency in Holstein cows reared in Turkey. Acta Veterinaria Scandinavica 2010; 52 (1): 56. https://doi.org/10.1186/1751-0147-52-56
  • 10. Miller SA, Dykes DD, Polesk HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Research 1988; 16: 1215. https://doi.org/10.1093/nar/16.3.1215
  • 11. Gürses M, Dere N. Identification of the ERV Insertion of APOB Gene and Deletion of TFB1M Gene Associated with Lethal Haplotypes of Holstein Cattle Reared in Balıkesir Province, Türkiye. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2023: 29 (2): 145-150. https://doi.org/10.9775/kvfd.2022.28793
  • 12. Kamiński S, Ruść A. Cholesterol Deficiency - new genetic defect transmitted to Polish Holstein-Friesian cattle. Polish Journal of Veterinary Science 2016; 19 (4): 885-887. https://doi. org/10.1515/pjvs-2016-0110
  • 13. Li Y, Fang L, Liu L, Zhang S, Ma Z et al. The cholesterol- deficiency associated mutation in APOB segregates at low frequency in Chinese Holstein cattle. Canadian Journal of Animal Science 2018; 99 (2): 332-335. https://doi.org/10.1139/ cjas-2017-0108
  • 14. Khan MYA, Omar AI, He Y, Chen S, Zhang S et al. Prevalence of nine genetic defects in Chinese Holstein cattle. Veterinary Medicine and Science 2021; 7 (5): 1728-1735. https://doi. org/10.1002/vms3.525
  • 15. Pozovnikova MV, Gladyr EA, Romanenkova OS, Vasileva OK, Leibova VB et al. Screening of haplotype for cholesterol deficiency genetic defect in the Russian Holstein cattle population. Polish Journal of Veterinary Science 2020; 23 (2): 313-315. https://doi.org/10.24425/pjvs.2020.133647
  • 16. Meydan H, Uğurlu M, Yıldız MA. Monitoring of BLAD, DUMPS, CVM, BC and FXID in Turkish Native Cattle Breeds. Journal of Agricultural Sciences 2012; 18 (3): 239-245. https:// doi.org/10.1501/Tarimbil_0000001211
APA MEYDAN H, Bedir K, vural o, YILDIZ M, Agerholm J (2023). Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. , 584 - 587.
Chicago MEYDAN HASAN,Bedir Kübra,vural onur,YILDIZ MEHMET ALİ,Agerholm Jørgen Steen Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. (2023): 584 - 587.
MLA MEYDAN HASAN,Bedir Kübra,vural onur,YILDIZ MEHMET ALİ,Agerholm Jørgen Steen Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. , 2023, ss.584 - 587.
AMA MEYDAN H,Bedir K,vural o,YILDIZ M,Agerholm J Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. . 2023; 584 - 587.
Vancouver MEYDAN H,Bedir K,vural o,YILDIZ M,Agerholm J Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. . 2023; 584 - 587.
IEEE MEYDAN H,Bedir K,vural o,YILDIZ M,Agerholm J "Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye." , ss.584 - 587, 2023.
ISNAD MEYDAN, HASAN vd. "Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye". (2023), 584-587.
APA MEYDAN H, Bedir K, vural o, YILDIZ M, Agerholm J (2023). Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. Turkish Journal of Veterinary and Animal Sciences, 47(6), 584 - 587.
Chicago MEYDAN HASAN,Bedir Kübra,vural onur,YILDIZ MEHMET ALİ,Agerholm Jørgen Steen Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. Turkish Journal of Veterinary and Animal Sciences 47, no.6 (2023): 584 - 587.
MLA MEYDAN HASAN,Bedir Kübra,vural onur,YILDIZ MEHMET ALİ,Agerholm Jørgen Steen Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. Turkish Journal of Veterinary and Animal Sciences, vol.47, no.6, 2023, ss.584 - 587.
AMA MEYDAN H,Bedir K,vural o,YILDIZ M,Agerholm J Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. Turkish Journal of Veterinary and Animal Sciences. 2023; 47(6): 584 - 587.
Vancouver MEYDAN H,Bedir K,vural o,YILDIZ M,Agerholm J Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. Turkish Journal of Veterinary and Animal Sciences. 2023; 47(6): 584 - 587.
IEEE MEYDAN H,Bedir K,vural o,YILDIZ M,Agerholm J "Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye." Turkish Journal of Veterinary and Animal Sciences, 47, ss.584 - 587, 2023.
ISNAD MEYDAN, HASAN vd. "Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye". Turkish Journal of Veterinary and Animal Sciences 47/6 (2023), 584-587.