Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue

AKAR, Ayşegül; AKGUN UNAL, NILUFER; Gülbahçe Mutlu, Elif; Korunur Engiz, Begum; AKKOCA, Ahmet; Varol, Salih

doi:10.58600/eurjther1875

Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue

Ayşegül Karadayı, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Samsun, Türkiye)

Nilüfer Akgün Ünal, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Samsun, Türkiye)

Elif Gülbahçe Mutlu, (KTO Karatay Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Bölümü, Konya, Türkiye)

Begüm Korunur Engiz, (Ondokuz Mayıs Üniversitesi, Mühendislik Fakültesi, Elektrik Elektronik Mühendisliği Bölümü, Samsun, Türkiye)

Ahmet Akkoca, (Selçuk Üniversitesi, Taşkent Meslek Yüksekokulu, İş Sağlığı ve Güvenliği Bölümü, Konya, Türkiye)

Salih Varol (Erciyes Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Kayseri, Türkiye)

European Journal of Therapeutics

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Yıl: 2023 Cilt: 29 Sayı: 4 Sayfa Aralığı: 846 - 855 Metin Dili: İngilizce DOI: 10.58600/eurjther1875 İndeks Tarihi: 21-01-2024

Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue

Öz:

Objective: The increasing use of electronic devices, accompanied by advancing technologies, has led to heightened exposure to non-ionizing electromagnetic radiation (EMR). This exposure instigates the accumulation of free radicals and oxidative damage in tissues, consequently impacting biological systems. Notably, the testis is among the tissues adversely affected by EMR. Numerous studies have highlighted the pivotal role of the testis in sperm production, emphasizing the potential implications of any damage on the reproductive system. This study aims to assess the levels of lipid peroxidation through histological evaluation in the testicular tissue of prepubertal male rats exposed to electromagnetic radiation at varying electric field intensities within the 2.45 GHz radiofrequency (RF) range. Methods: The experimental group comprises six subdivisions, including a sham control group, as well as groups exposed to varying electric field strengths (EFS) of 0.6 V/m, 1.9 V/m, 5 V/m, 10 V/m, and 15 V/m, respectively. Excluding the sham control group, the remaining subgroups were subjected to a daily 2.45 GHz RF exposure for 1 hour starting immediately after fertilization. This exposure to different electric field intensities continued for 45 days post-birth. Results: The samples obtained from the RF radiation-exposed rats exhibited elevated malondialdehyde (MDA) values and decreased glutathione (GSH) values in the testicular tissue. Furthermore, a comparative analysis between the microwave radiation-exposed group and the control group revealed distinct histological alterations in the testicular tissue. Conclusion: In conclusion, our findings indicate that exposure to microwave radiation at an electric field intensity of 15 V/m can lead to significant histopathological and oxidative parameter changes in Wistar rats. These results underscore the potential effects of such exposure on human health.

Anahtar Kelime: Testicular Injury Prepubertal Rats Malondialdehyde Glutathione Radiofrequency

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AKAR A, AKGUN UNAL N, Gülbahçe Mutlu E, Korunur Engiz B, AKKOCA A, Varol S (2023). Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. , 846 - 855. 10.58600/eurjther1875
Chicago	AKAR Ayşegül,AKGUN UNAL NILUFER,Gülbahçe Mutlu Elif,Korunur Engiz Begum,AKKOCA Ahmet,Varol Salih Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. (2023): 846 - 855. 10.58600/eurjther1875
MLA	AKAR Ayşegül,AKGUN UNAL NILUFER,Gülbahçe Mutlu Elif,Korunur Engiz Begum,AKKOCA Ahmet,Varol Salih Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. , 2023, ss.846 - 855. 10.58600/eurjther1875
AMA	AKAR A,AKGUN UNAL N,Gülbahçe Mutlu E,Korunur Engiz B,AKKOCA A,Varol S Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. . 2023; 846 - 855. 10.58600/eurjther1875
Vancouver	AKAR A,AKGUN UNAL N,Gülbahçe Mutlu E,Korunur Engiz B,AKKOCA A,Varol S Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. . 2023; 846 - 855. 10.58600/eurjther1875
IEEE	AKAR A,AKGUN UNAL N,Gülbahçe Mutlu E,Korunur Engiz B,AKKOCA A,Varol S "Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue." , ss.846 - 855, 2023. 10.58600/eurjther1875
ISNAD	AKAR, Ayşegül vd. "Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue". (2023), 846-855. https://doi.org/10.58600/eurjther1875

APA	AKAR A, AKGUN UNAL N, Gülbahçe Mutlu E, Korunur Engiz B, AKKOCA A, Varol S (2023). Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. European Journal of Therapeutics, 29(4), 846 - 855. 10.58600/eurjther1875
Chicago	AKAR Ayşegül,AKGUN UNAL NILUFER,Gülbahçe Mutlu Elif,Korunur Engiz Begum,AKKOCA Ahmet,Varol Salih Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. European Journal of Therapeutics 29, no.4 (2023): 846 - 855. 10.58600/eurjther1875
MLA	AKAR Ayşegül,AKGUN UNAL NILUFER,Gülbahçe Mutlu Elif,Korunur Engiz Begum,AKKOCA Ahmet,Varol Salih Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. European Journal of Therapeutics, vol.29, no.4, 2023, ss.846 - 855. 10.58600/eurjther1875
AMA	AKAR A,AKGUN UNAL N,Gülbahçe Mutlu E,Korunur Engiz B,AKKOCA A,Varol S Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. European Journal of Therapeutics. 2023; 29(4): 846 - 855. 10.58600/eurjther1875
Vancouver	AKAR A,AKGUN UNAL N,Gülbahçe Mutlu E,Korunur Engiz B,AKKOCA A,Varol S Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue. European Journal of Therapeutics. 2023; 29(4): 846 - 855. 10.58600/eurjther1875
IEEE	AKAR A,AKGUN UNAL N,Gülbahçe Mutlu E,Korunur Engiz B,AKKOCA A,Varol S "Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue." European Journal of Therapeutics, 29, ss.846 - 855, 2023. 10.58600/eurjther1875
ISNAD	AKAR, Ayşegül vd. "Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue". European Journal of Therapeutics 29/4 (2023), 846-855. https://doi.org/10.58600/eurjther1875