Chest pain in children with familial Mediterranean fever

Sunar Yayla, Emine Nur; Esmeray Şenol, Pelin; GEZGİN YİLDİRİM, DENİZ; Soylemezoglu, Oguz

doi:10.24953/turkjped.2023.227

Chest pain in children with familial Mediterranean fever

Emine Nur Sunar Yayla, (Gazi Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Romatoloji Bilim Dalı, Ankara, Türkiye)

Pelin Esmeray Şenol, (Gazi Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Romatoloji Bilim Dalı, Ankara, Türkiye)

Deniz Gezgin Yıldırım, (Gazi Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Romatoloji Bilim Dalı, Ankara, Türkiye)

Oğuz Söylemezoğlu (Gazi Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Romatoloji Bilim Dalı, Ankara, Türkiye)

Turkish Journal of Pediatrics

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Yıl: 2023 Cilt: 65 Sayı: 6 Sayfa Aralığı: 973 - 979 Metin Dili: İngilizce DOI: 10.24953/turkjped.2023.227 İndeks Tarihi: 22-01-2024

Chest pain in children with familial Mediterranean fever

Öz:

Background. Familial Mediterranean fever (FMF) is the most common and autosomal recessive inherited autoinflammatory disease. The most common signs and symptoms are fever, abdominal pain, chest pain, and arthritis. The aim of this study was to describe the clinical, laboratory and genetic differences between pediatric FMF patients with and without chest pain. Methods. Between January 2006 and January 2022, 1134 patients with FMF were analyzed retrospectively. Patients were divided into two groups including those with and without recurrent chest pain. These groups were compared in demographic, clinical, treatment, and MEFV gene analyses. Results. A hundred and sixty-two (14.3%) patients had recurrent chest pain. In patients with recurrent chest pain, the age of onset of symptoms was younger (p=0.003), and the family history of FMF was higher (p=0.002). Patients with chest pain had a higher annual attack frequency (p<0.001), a longer attack duration (p<0.001), and higher Pras disease activity scores (p<0.001). The colchicine dose used in the treatment was higher in FMF patients with chest pain (p=0.005), and anti-IL-1treatment was higher (p<0.001). M694V homozygous mutation was found more frequently (p=0.001), whereas M694V/V726A mutation was found less frequently in patients with recurrent chest pain (p=0.017). Conclusions. Patients with recurrent chest pain seem to have early onset symptoms, often are more likely to have family history, and have a higher disease severity. In addition, the presence of homozygous M694V mutation is more common in patients with chest pain.

Anahtar Kelime: chest pain familial Mediterranean fever pleurisy pyrin

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Sunar Yayla E, Esmeray Şenol P, GEZGİN YİLDİRİM D, Soylemezoglu O (2023). Chest pain in children with familial Mediterranean fever. , 973 - 979. 10.24953/turkjped.2023.227
Chicago	Sunar Yayla Emine Nur,Esmeray Şenol Pelin,GEZGİN YİLDİRİM DENİZ,Soylemezoglu Oguz Chest pain in children with familial Mediterranean fever. (2023): 973 - 979. 10.24953/turkjped.2023.227
MLA	Sunar Yayla Emine Nur,Esmeray Şenol Pelin,GEZGİN YİLDİRİM DENİZ,Soylemezoglu Oguz Chest pain in children with familial Mediterranean fever. , 2023, ss.973 - 979. 10.24953/turkjped.2023.227
AMA	Sunar Yayla E,Esmeray Şenol P,GEZGİN YİLDİRİM D,Soylemezoglu O Chest pain in children with familial Mediterranean fever. . 2023; 973 - 979. 10.24953/turkjped.2023.227
Vancouver	Sunar Yayla E,Esmeray Şenol P,GEZGİN YİLDİRİM D,Soylemezoglu O Chest pain in children with familial Mediterranean fever. . 2023; 973 - 979. 10.24953/turkjped.2023.227
IEEE	Sunar Yayla E,Esmeray Şenol P,GEZGİN YİLDİRİM D,Soylemezoglu O "Chest pain in children with familial Mediterranean fever." , ss.973 - 979, 2023. 10.24953/turkjped.2023.227
ISNAD	Sunar Yayla, Emine Nur vd. "Chest pain in children with familial Mediterranean fever". (2023), 973-979. https://doi.org/10.24953/turkjped.2023.227

APA	Sunar Yayla E, Esmeray Şenol P, GEZGİN YİLDİRİM D, Soylemezoglu O (2023). Chest pain in children with familial Mediterranean fever. Turkish Journal of Pediatrics, 65(6), 973 - 979. 10.24953/turkjped.2023.227
Chicago	Sunar Yayla Emine Nur,Esmeray Şenol Pelin,GEZGİN YİLDİRİM DENİZ,Soylemezoglu Oguz Chest pain in children with familial Mediterranean fever. Turkish Journal of Pediatrics 65, no.6 (2023): 973 - 979. 10.24953/turkjped.2023.227
MLA	Sunar Yayla Emine Nur,Esmeray Şenol Pelin,GEZGİN YİLDİRİM DENİZ,Soylemezoglu Oguz Chest pain in children with familial Mediterranean fever. Turkish Journal of Pediatrics, vol.65, no.6, 2023, ss.973 - 979. 10.24953/turkjped.2023.227
AMA	Sunar Yayla E,Esmeray Şenol P,GEZGİN YİLDİRİM D,Soylemezoglu O Chest pain in children with familial Mediterranean fever. Turkish Journal of Pediatrics. 2023; 65(6): 973 - 979. 10.24953/turkjped.2023.227
Vancouver	Sunar Yayla E,Esmeray Şenol P,GEZGİN YİLDİRİM D,Soylemezoglu O Chest pain in children with familial Mediterranean fever. Turkish Journal of Pediatrics. 2023; 65(6): 973 - 979. 10.24953/turkjped.2023.227
IEEE	Sunar Yayla E,Esmeray Şenol P,GEZGİN YİLDİRİM D,Soylemezoglu O "Chest pain in children with familial Mediterranean fever." Turkish Journal of Pediatrics, 65, ss.973 - 979, 2023. 10.24953/turkjped.2023.227
ISNAD	Sunar Yayla, Emine Nur vd. "Chest pain in children with familial Mediterranean fever". Turkish Journal of Pediatrics 65/6 (2023), 973-979. https://doi.org/10.24953/turkjped.2023.227