Yıl: 2024 Cilt: 46 Sayı: 1 Sayfa Aralığı: 17 - 22 Metin Dili: İngilizce DOI: 10.20515/otd.1373902 İndeks Tarihi: 06-02-2024

Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study

Öz:
The aim was to evaluate if foods, against which patient has IgG antibodies, trigger tension type headache (TTH). 22 patients (8 male, 14 female; 8 chronic TTH, 14 frequent episodic TTH) were recruited. The study had four periods: cooperation, provocation, free diet month and elimination were determined. At the cooperation perido patients’ cooperation abilities were checked. All patients were screened for 271 different antibodies against foods using Imupro300. Thus a list of food sensitivity was described for each patient. In provocation period,those detected foods were added to diet. In elimination period, those foods were eliminated from the diet with false foods added. In free diet month, there were no restrictions. Patients recorded the number of the days with headache as well as headache frequency, severity and duration and analgesic intake. These headache features in cooperation, provocation and elimination periods were compared. In the elimination period there was a significant decrease in the number of days with headache, headache frequency and duration in all patients. A significant increase in these three features were observed in the provocation period. In chronic TTH patients, only the number of the days with headache significantly increased in provocation period. IgG antibodies against foods may have a role in TTH. Number of days with headache, headache frequency and duration can be decreased by eliminating related foods from the diet, and this can be a part of the treatment. IgG antibodies against foods may be one of the pathophysiological mechanisms triggering TTH.
Anahtar Kelime: Tension type headache IgG Food allergy

Immünoglobulin G Antikorlarına Dayalı Gıda Eliminasyonu Gerilim Tipi Baş Ağrısını Azaltır Mı? – Randomize Çapraz Çalışma

Öz:
Bu çalışmanın amacı, hastada IgG antikoru bulunan besinlerin gerilim tipi baş ağrısını (GTBA) tetikleyip tetiklemediğini değerlendirmektir. Toplam 22 hasta (8 erkek, 14 kadın; 8 kronik GTBA, 14 sık epizodik GTBA) çalışmaya alındı. Çalışmanın dört dönemi vardı: kooperasyon, provokasyon, serbest dönem ve eliminasyon dönemi. Kooperasyon döneminde hastaların kooperasyon yetenekleri kontrol edildi. Tüm hastalar, Imupro300 kullanılarak gıdalara karşı 271 farklı antikor açısından tarandı ve her hasta için bir besin duyarlılığı listesi tanımlandı. Provokasyon döneminde tespit edilen besinler diyete eklendi. Eliminasyon döneminde hastanın antikoru olmayan besinler diyete eklenerek alerjik besinler diyetten çıkarıldı. Serbest diyet ayında herhangi bir kısıtlama yoktu. Hastalar baş ağrısının olduğu gün sayısını, baş ağrısının sıklığını, şiddetini ve süresini ve analjezik alımını kaydetti. Kooperasyon, provokasyon ve eliminasyon dönemlerindeki bu baş ağrısı özellikleri karşılaştırıldı. Eliminasyon periyodunda tüm hastalarda baş ağrısı olan gün sayısında, baş ağrısı sıklığında ve süresinde anlamlı azalma oldu. Provokasyon döneminde bu üç özellikte de önemli bir artış gözlendi. Kronik GTBA hastalarında provokasyon döneminde sadece baş ağrısı olan gün sayısı anlamlı olarak arttı. Gıdalara karşı IgG antikorlarının GTBA’da rolü olabilir. İlgili besinlerin diyetten çıkarılmasıyla baş ağrılı gün sayısı, baş ağrısı sıklığı ve süresi azaltılabilir ve bu tedavinin bir parçası olabilir. Gıdalara karşı IgG antikorları, GTBA’yı tetikleyen patofizyolojik mekanizmalardan biri olabilir.
Anahtar Kelime: Gerilim tipi baş ağrısı IgG Gıda alerjisi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808.
  • 2. Yu S1, Han X. Update of chronic tension-type headache. Curr Pain Headache Rep. 2015;19(1):469.
  • 3. Crystal SC, Robbins MS. Epidemiology of tension-type headache. Curr Pain Headache Rep. 2010;14(6):449-54.
  • 4. Steiner TJ, Birbeck GL, Jensen RH, Katsarava Z, Stovner LJ, Martelletti P. Headache disorders are third cause of disability worldwide. J Headache Pain. 2015;16:58.
  • 5. Ayzenberg I, Katsarava Z, Sborowski A, Chernysh M, Osipova V, Tabeeva G, Steiner TJ. Headache-attributed burden and its impact on productivity and quality of life in Russia: structured healthcare for headache is urgently needed. Eur J Neurol. 2014;21(5):758-65.
  • 6. Cady RK. The Convergence Hypothesis. Headache. 2007 Apr;47 Suppl 1:S44-51.
  • 7. İrkec C, Batur HZ,Aksoy O,Doğanay H. The Neuroimmunologic Approach to Tension Type Headache and Migraine. Journal of Neurological Sciences (Turkish). 2006;12(2): 129-133.
  • 8. Alpay K, Ertas M, Orhan EK, Ustay DK, Lieners C, Baykan B. Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised, cross-over trial. Cephalalgia. 2010;30(7):829-37.
  • 9. Arroyave Hernández CM, Echavarria Pinto M, Hernández Montiel HL. Food allergy mediated by IgG antibodies associated with migraine in adults. Rev Alerg Mex. 2007;54(5):162-8.
  • 10. Aydınlar EI, Diken PY, Tiftikçi A, Saruc M, Aksu M, Gunsoy HG, Tozun N. IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache. 2013;53(3):514-25.
  • 11. Egger J, Carter CM, Wilson J, Turner MW, Soothill JF. Is migraine food allergy? A double-blind controlled trial of oligoantigenic diet treatment.Lancet. 1983;2(8355):865-9.
  • 12. Rees T, Watson D, Lipscombe S,Speight H, Cousins P, Hardman G,Dowson AJ. A prospective audit of food intolerance among migraine patients in prinmary care clinical practice. Headache Care.2005 June vol2,no2. pp105-110(6).
  • 13. Mitchell N, Hewitt CE, Jayakody, Islam M, Adamson J,Watt I,Torgerson DJ. Randomised controlled trial of food elimination d,et based on IgG antibodies for the prevention of migraine like headaches. Nutrition Journal 2011 :10:85.
  • 14. Waters WE. The epidemiological enigma of migraine. Int J Epiderniol. 1973;2:189–194.
  • 15. Cady RK, Gutterman DL, Saiers JA, Beach ME. Respon- siveness of non-IHS migraine and tension-type headache to sumatriptan. Cephalalgia 1997; 17:588–90.
  • 16. Karli N, Zarifoglu M, Calisir N, Akgoz S. Comparison of pre-headache phases and trigger factors of migraine and episodic tension-type headache: do they share similar clinical pathophysiology. Cephalalgia. 2005 ;25(6):444-51
  • 17. Cady R, Schreiber C, Farmer K, Sheftell F. Primary headaches: a convergence hypothesis. Headache. 2002; 42(3):204-16.
APA Durmaz Çelik F, SENER H (2024). Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. , 17 - 22. 10.20515/otd.1373902
Chicago Durmaz Çelik Fatma Nazli,SENER H. Ozden Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. (2024): 17 - 22. 10.20515/otd.1373902
MLA Durmaz Çelik Fatma Nazli,SENER H. Ozden Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. , 2024, ss.17 - 22. 10.20515/otd.1373902
AMA Durmaz Çelik F,SENER H Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. . 2024; 17 - 22. 10.20515/otd.1373902
Vancouver Durmaz Çelik F,SENER H Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. . 2024; 17 - 22. 10.20515/otd.1373902
IEEE Durmaz Çelik F,SENER H "Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study." , ss.17 - 22, 2024. 10.20515/otd.1373902
ISNAD Durmaz Çelik, Fatma Nazli - SENER, H. Ozden. "Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study". (2024), 17-22. https://doi.org/10.20515/otd.1373902
APA Durmaz Çelik F, SENER H (2024). Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. Osmangazi Tıp Dergisi, 46(1), 17 - 22. 10.20515/otd.1373902
Chicago Durmaz Çelik Fatma Nazli,SENER H. Ozden Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. Osmangazi Tıp Dergisi 46, no.1 (2024): 17 - 22. 10.20515/otd.1373902
MLA Durmaz Çelik Fatma Nazli,SENER H. Ozden Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. Osmangazi Tıp Dergisi, vol.46, no.1, 2024, ss.17 - 22. 10.20515/otd.1373902
AMA Durmaz Çelik F,SENER H Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. Osmangazi Tıp Dergisi. 2024; 46(1): 17 - 22. 10.20515/otd.1373902
Vancouver Durmaz Çelik F,SENER H Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study. Osmangazi Tıp Dergisi. 2024; 46(1): 17 - 22. 10.20515/otd.1373902
IEEE Durmaz Çelik F,SENER H "Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study." Osmangazi Tıp Dergisi, 46, ss.17 - 22, 2024. 10.20515/otd.1373902
ISNAD Durmaz Çelik, Fatma Nazli - SENER, H. Ozden. "Does Food Elimination Based on Immunoglobulin G Antibodies Diminish Tension-Type Headache?A Randomised Cross-Over Study". Osmangazi Tıp Dergisi 46/1 (2024), 17-22. https://doi.org/10.20515/otd.1373902