As a result of increasing scientific and technological studies in recent years, studies in materials science have accelerated and interest in nanotechnology has increased. Nanomaterials also form the basis of nanotechnology and have unique optical, magnetic and electrical properties in this dimension. What makes nanotechnology so interesting is that materials behave differently in this dimension than in the macro world. While passing from the macro dimension to the nano dimension, the large surface area/volume ratio, conductivity, optical and magnetic properties change considerably and thus offer a wide perspective research opportunity. The discovery of graphene, a two-dimensional (2D) material, pioneered the development of nanodetectors and became very popular. This popularity of graphene has led to the discovery of other graphene-like 2D materials, and search for new 2D materials with different properties has begun. One of the most important recent discoveries in this field is the monolayer phosphorene structure. Studies continued with the discovery of compounds formed by phosphorus with other V-A group elements. One of the interesting examples here is the blue arsenic-phosphorene (ß-AsP) structure. ß-AsP, draws attention in terms of its possible usability in new and sensitive technologies due to its features such as adjustable wide band gap, high conductivity, high carrier mobility. Also, thanks to its buckled zigzag structure, its surface area is quite large, and therefore it has a high ability to hold molecules approaching in different configurations. This means that if ß-AsP is used as a substrate, much more functional 2D structures can emerge. In this project, the interactions of the ß-AsP monolayer surface with the biological molecules Glycine and Serine at the atomic scale were investigated with calculations based on first principles. Glycine and Serine molecules, which are among the most basic amino acids, play an important role in the treatment process of many diseases. Therefore, it is very important that these molecules can be detected and transported without undergoing structural deformation. At this point, it has become important to investigate whether ß-AsP can be a good substrate for this type of biological molecules. Calculations in the project were made using Density Functional Theory (DFT) based on quantum mechanics. Quantum Espresso and VASP programs, which are widely used worldwide, were used as software. All possible adsorption geometries of Glycine and Serine molecules on ß-AsP were determined and the structural and electronic properties of these configurations were examined.