Yıl: 2024 Cilt: 29 Sayı: 1 Sayfa Aralığı: 105 - 115 Metin Dili: İngilizce DOI: 10.5578/flora.202401777 İndeks Tarihi: 26-03-2024

An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms

Öz:
Introduction: This study aims to investigate the correlation between interleukin-6 (IL-6) (-174 G>C) and tumor necrosis factor-alpha (TNF-α) (-238 G>A) cytokine gene polymorphisms and diabetic foot infection (DFI). Materials and Methods: This study involved the collection of blood samples from a total of 207 participants who were grouped as follows: a control group of 60 healthy individuals, a group of 60 patients with type 2 diabetes mellitus (T2DM) but without diabetic foot ulcer (DFU), and a group of 87 patients with DFI. The genotypes of IL-6 (-174 G>C) and TNF-α (-238 G>A) polymorphisms were determined using real-time PCR and the TaqMan method. Results: The findings indicate that there were no statistically significant variations in the distribution of IL-6 (-174 G>C) and TNF-α (-238 G>A) polymorphisms genotypes among individuals with T2DM who had DFI, individuals with T2DM without DFU, and the control group (p> 0.05). A higher prevalence of osteomyelitis was detected in patients with DFI possessing the GG genotype (53.1%) of the IL-6 (-174 G>C) polymorphism, compared to those with the mutant genotypes (GC + CC) (28.9%) (p= 0.024). The study revealed a higher prevalence of venous insufficiency (VI) in individuals with DFI possessing TNF-α (-238 G>A) GA genotype compared to those with the GG genotype (80.0%, 24.4%, respectively) (p= 0.007). The study indicated that patients with DFI possessing the TNF-α (-238 G>A) GA genotype had a higher mean body mass index (BMI) compared to those with the GG genotype (p= 0.012). Conclusion: The study has demonstrated that the IL-6 (-174 G>C) and TNF-α (-238 G>A) polymorphisms cannot serve as reliable indicators for determining an individual’s vulnerability to DFI and T2DM. The IL-6 (-174 G>C) polymorphism’s GG genotype exhibited a significant association with osteomyelitis in patients with DFI. Findings suggest that individuals with the TNF-α (-238 G>A) GA genotype in DFI patients may experience VI and higher average BMI than patients with the GG genotype.
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APA Inan Sarikaya R, PARLAK E, Yuce Kahraman C, Yılmaz S (2024). An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. , 105 - 115. 10.5578/flora.202401777
Chicago Inan Sarikaya Rukiye,PARLAK EMINE,Yuce Kahraman Cigdem,Yılmaz Sinan An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. (2024): 105 - 115. 10.5578/flora.202401777
MLA Inan Sarikaya Rukiye,PARLAK EMINE,Yuce Kahraman Cigdem,Yılmaz Sinan An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. , 2024, ss.105 - 115. 10.5578/flora.202401777
AMA Inan Sarikaya R,PARLAK E,Yuce Kahraman C,Yılmaz S An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. . 2024; 105 - 115. 10.5578/flora.202401777
Vancouver Inan Sarikaya R,PARLAK E,Yuce Kahraman C,Yılmaz S An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. . 2024; 105 - 115. 10.5578/flora.202401777
IEEE Inan Sarikaya R,PARLAK E,Yuce Kahraman C,Yılmaz S "An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms." , ss.105 - 115, 2024. 10.5578/flora.202401777
ISNAD Inan Sarikaya, Rukiye vd. "An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms". (2024), 105-115. https://doi.org/10.5578/flora.202401777
APA Inan Sarikaya R, PARLAK E, Yuce Kahraman C, Yılmaz S (2024). An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 29(1), 105 - 115. 10.5578/flora.202401777
Chicago Inan Sarikaya Rukiye,PARLAK EMINE,Yuce Kahraman Cigdem,Yılmaz Sinan An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 29, no.1 (2024): 105 - 115. 10.5578/flora.202401777
MLA Inan Sarikaya Rukiye,PARLAK EMINE,Yuce Kahraman Cigdem,Yılmaz Sinan An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.29, no.1, 2024, ss.105 - 115. 10.5578/flora.202401777
AMA Inan Sarikaya R,PARLAK E,Yuce Kahraman C,Yılmaz S An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2024; 29(1): 105 - 115. 10.5578/flora.202401777
Vancouver Inan Sarikaya R,PARLAK E,Yuce Kahraman C,Yılmaz S An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2024; 29(1): 105 - 115. 10.5578/flora.202401777
IEEE Inan Sarikaya R,PARLAK E,Yuce Kahraman C,Yılmaz S "An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 29, ss.105 - 115, 2024. 10.5578/flora.202401777
ISNAD Inan Sarikaya, Rukiye vd. "An Investigation on the Correlation Between Diabetic Foot Infection, Osteomyelitis, Venous Insufficiency, and IL-6 (-174 G>C) and TNF-α (-238 G>A) Gene Polymorphisms". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 29/1 (2024), 105-115. https://doi.org/10.5578/flora.202401777