Yıl: 2024 Cilt: 29 Sayı: 1 Sayfa Aralığı: 85 - 95 Metin Dili: İngilizce DOI: 10.5578/flora.202401868 İndeks Tarihi: 26-03-2024

Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children

Öz:
Introduction: Staphylococcus aureus is a major cause of skin and soft tissue infections (SSTIs). This study aimed to determine the antimicrobial susceptibility and clinical and epidemiological characteristics of community-acquired SSTIs caused by methicillin-susceptible and methicillin-resistant S. aureus (MSSA-MRSA) in children. Materials and Methods: This was a retrospective, single-center study of pediatric SSTIs caused by S. aureus at a tertiary care hospital in Türkiye between January 2014 and November 2019. Results: Demographic, clinical, and microbiological data of 431 patients were examined during the study period. Overall, 333 (77.3%) isolates were MSSA, and 98 (22.7%) were MRSA. Antibiotic courses and hospital stays were significantly longer in patients with MRSA infection. The antimicrobial susceptibility patterns for 17 antibiotics were assessed in both MSSA and MRSA isolates. Penicillin resistance rate was 91%, while fosfomycin, gentamicin, mupirocin, trimethoprim-sulfamethoxazole, and fusidic acid resistance rates were 1.2%, 3.2%, 2.7%, 4.2%, and 8.1%, respectively. All S. aureus isolates were susceptible to teicoplanin, vancomycin, linezolid, and tigecycline, and 335 (77%) isolates showed susceptibility to daptomycin. A statistically significant increase was detected in resistance of MSSA isolates to trimethoprim-sulfamethoxazole in 2019 compared to 2014, 2015, 2016 and 2018 (p1= 0.029 (2014 vs. 2019); p2= 0.008 (2015 vs. 2019); p3= 0.019 (2016 vs. 2019); p4= 0.032 (2018 vs. 2019). Conclusion: S. aureus strains causing SSTIs showed a continued high prevalence of MSSA and multi-drug susceptibility. A striking result was the detection of increased resistance to trimethoprim-sulfamethoxazole, which was frequently used in oral therapy against MSSA strains in 2019 compared to the other years. These results may provide guidance for clinical management of SSTIs in children.
Anahtar Kelime: Antimicrobial susceptibility Skin and soft tissue infection Staphylococcus aureus Children

Çocuklarda Staphylococcus aureus Kaynaklı Cilt ve Yumuşak Doku İnfeksiyonlarının Özellikleri ve Antimikrobiyal Duyarlılık

Öz:
Giriş: Staphylococcus aureus, cilt ve yumuşak doku infeksiyonlarının (CYDİ) en sık etkenlerinden birisidir. Bu çalışmada çocuklarda metisiline duyarlı ve metisiline dirençli S. aureus’un (MSSA-MRSA) neden olduğu CYDİ’lerin klinik ve epidemiyolojik özelliklerini ve anti- mikrobiyal duyarlılıklarını tanımlamayı amaçladık. Materyal ve Metod: Ocak 2014 ile Kasım 2019 yılları arasında, İstanbul’daki üçüncü basamak bir hastanede izlenen S. aureus kaynaklı CYDİ tanılı çocuk hastaların kayıtları retrospektif olarak incelendi. Bulgular: Çalışma süresince toplam 431 hastanın demografik, klinik ve mikrobiyolojik özellikleri tanımlandı. Toplam 333 (%77.3) izolat MSSA ve 98 (%22.7) izolat MRSA olarak saptandı. Antibiyotik kullanım ve hastane yatış süresi MRSA kaynaklı infeksiyonlarda istatis- tiksel olarak anlamlı düzeyde uzun saptandı. MSSA ve MRSA izolatlarının 17 antimikrobiyal ajana karşı duyarlılıkları değerlendirildi. Penisiline direnç oranı %91, fosfomisine, gentamisine, mupirosine, trimetoprim-sülfametoksazole ve fusidik aside karşı direnç oranları sırasıyla %1.2, %3.2, %2.7, %4.2 ve %8.1 olarak saptandı. Antimikrobiyal duyarlılık testine göre, tüm S. aureus izolatları teikoplanin, vankomisin, linezolid ve tigesikline, duyarlılık testi çalışılan 335 (%77) izolat daptomisine duyarlıydı. 2019 yılında, 2014, 2015,2016 ve 2018 yılları ile karşılaştırıldığında MSSA izolatlarının trimetoprim-sülfametoksazol direncinde istatistiksel olarak anlamlı bir artış tespit edildi (p 1= 0.029 (2014’e karşı 2019); p2= 0.008 (2015’e karşı 2019); p3= 0.019 (2016’ya karşı 2019); p4= 0.032 (2018’e karşı 2019). Sonuç: Cilt ve yumuşak doku infeksiyonlarına neden olan S. aureus izolatlarında MSSA baskınlığı ve çoklu ilaç duyarlılığı saptanmıştır. Oral tedavide, özellikle MSSA suşlarına karşı kullanılan trimetoprim-sülfametoksazole karşı artan direnç dikkat çekmektedir. Bu sonuçlar, çocuklarda S. aureus’un neden olduğu CYDİ’lerin daha iyi yönetilmesinde yol gösterici olabilir.
Anahtar Kelime: Antimikrobiyal duyarlılık Cilt yumuşak doku infeksiyonları Staphylococcus aureus Çocuklar

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Yakut N, Ergenç Z, Bayraktar S, Akbolat F, Sayın E, Ilki A, Kepenekli E (2024). Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. , 85 - 95. 10.5578/flora.202401868
Chicago Yakut Nurhayat,Ergenç Zeynep,Bayraktar Sezin,Akbolat Fikriye İrem,Sayın Elvan,Ilki Arzu,Kepenekli Eda Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. (2024): 85 - 95. 10.5578/flora.202401868
MLA Yakut Nurhayat,Ergenç Zeynep,Bayraktar Sezin,Akbolat Fikriye İrem,Sayın Elvan,Ilki Arzu,Kepenekli Eda Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. , 2024, ss.85 - 95. 10.5578/flora.202401868
AMA Yakut N,Ergenç Z,Bayraktar S,Akbolat F,Sayın E,Ilki A,Kepenekli E Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. . 2024; 85 - 95. 10.5578/flora.202401868
Vancouver Yakut N,Ergenç Z,Bayraktar S,Akbolat F,Sayın E,Ilki A,Kepenekli E Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. . 2024; 85 - 95. 10.5578/flora.202401868
IEEE Yakut N,Ergenç Z,Bayraktar S,Akbolat F,Sayın E,Ilki A,Kepenekli E "Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children." , ss.85 - 95, 2024. 10.5578/flora.202401868
ISNAD Yakut, Nurhayat vd. "Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children". (2024), 85-95. https://doi.org/10.5578/flora.202401868
APA Yakut N, Ergenç Z, Bayraktar S, Akbolat F, Sayın E, Ilki A, Kepenekli E (2024). Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 29(1), 85 - 95. 10.5578/flora.202401868
Chicago Yakut Nurhayat,Ergenç Zeynep,Bayraktar Sezin,Akbolat Fikriye İrem,Sayın Elvan,Ilki Arzu,Kepenekli Eda Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 29, no.1 (2024): 85 - 95. 10.5578/flora.202401868
MLA Yakut Nurhayat,Ergenç Zeynep,Bayraktar Sezin,Akbolat Fikriye İrem,Sayın Elvan,Ilki Arzu,Kepenekli Eda Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.29, no.1, 2024, ss.85 - 95. 10.5578/flora.202401868
AMA Yakut N,Ergenç Z,Bayraktar S,Akbolat F,Sayın E,Ilki A,Kepenekli E Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2024; 29(1): 85 - 95. 10.5578/flora.202401868
Vancouver Yakut N,Ergenç Z,Bayraktar S,Akbolat F,Sayın E,Ilki A,Kepenekli E Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2024; 29(1): 85 - 95. 10.5578/flora.202401868
IEEE Yakut N,Ergenç Z,Bayraktar S,Akbolat F,Sayın E,Ilki A,Kepenekli E "Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 29, ss.85 - 95, 2024. 10.5578/flora.202401868
ISNAD Yakut, Nurhayat vd. "Antimicrobial Susceptibility Results and Characterization of Skin and Soft Tissue Infections Caused by Staphylococcus aureus in Children". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 29/1 (2024), 85-95. https://doi.org/10.5578/flora.202401868