Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study

Aydin, Nazan; ÖZBEK, Elvan; ÜNAL, Bünyamin; VURALER, ÖZGEN; ALTUNKAYNAK, B. Zuhal; AYDIN, Mehmet D.

Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study

Elvan ÖZBEK, (Atatürk Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Erzurum, Türkiye)

B. Zuhal ALTUNKAYNAK, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Samsun, Türkiye)

Mehmet D. AYDIN, (Atatürk Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Erzurum, Türkiye)

Nazan AYDIN, (Atatürk Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Erzurum, Türkiye)

ÖZGEN VURALER, (Atatürk Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Erzurum, Türkiye)

Bünyamin ÜNAL (Atatürk Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Erzurum, Türkiye)

Journal of Neurological Sciences (Turkish)

4 0

Yıl: 2010 Cilt: 27 Sayı: 4 Sayfa Aralığı: 438 - 445 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study

Öz:

Nöroleptik olarak kullanılan hapoperidol adlı ilacın nörotoksik olup olmadığı halen tartışılan bir konudur. Bu çalışmada haloperidolün kobay hipokampusu üzerinde oluşturabileceği olası toksik etkiler araştırıldı. Çalışma için 16 adet kobay iki gruba ayrıldı. Her iki grupta yer alan sekizer kobaya 6 hafta boyunca hergün eşit hacimde serum fizyolojik (kontrol) ya da 5 mg/kg haloperidol (deney)intraperitoneal olarak yapıldı. Deney sonunda tüm deneklerden elde edilen hipokampus örnekleri ışık ve elektron mikroskobik düzeyde incelendi. Deney grubu örneklerinde çok sayıda koyu boyanmış ve heterokromatik nükleuslu çalışmadan elde edilen bulgulara göre haloperidolün hipokampus üzerinde toksik hasara yol açabileceği söylenebilir. Ayrıca bu nöronlardan bazılarının vakuoler içeriği ve lizozomları artmıştı. Bu çalışmadan elde edilen sonuçlara gore haloperidolün hipokampus üzerinde nörotoksik etkiye sahip olabileceği söylenebilir.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Haloperidol kobay hipokampusunda nöronal hasar oluşturur: Mikroskobik bir çalışma

Öz:

Haloperidol, a neuroleptic drug, is still discussed if it is neurotoxic. In the present study, neurotoxic effects of haloperidol on guinea pig hippocampus were examined. Sixteen guinea pigs were randomly divided into two groups of 8 animals each. The animals of treatment group were given intraperitoneally (i.p.) haloperidol diluted in saline (dose of 5 mg/kg daily) for 6 weeks. Control animals received only the same volume of saline i.p. Hippocampi from both groups were examined by light and electron microscope. Numerous dark neurons with a heterochromatic nucleus and dense cytoplasm were observed in the hippocampi of the treatment group by light microscope and ultrastructural levels. Also some neurons have increased vacuolar contents and lysosomes. These findings suggest that haloperidol leads to prominent damage of hippocampal neurons.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZBEK E, ALTUNKAYNAK B, AYDIN M, Aydin N, VURALER Ö, ÜNAL B (2010). Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. , 438 - 445.
Chicago	ÖZBEK Elvan,ALTUNKAYNAK B. Zuhal,AYDIN Mehmet D.,Aydin Nazan,VURALER ÖZGEN,ÜNAL Bünyamin Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. (2010): 438 - 445.
MLA	ÖZBEK Elvan,ALTUNKAYNAK B. Zuhal,AYDIN Mehmet D.,Aydin Nazan,VURALER ÖZGEN,ÜNAL Bünyamin Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. , 2010, ss.438 - 445.
AMA	ÖZBEK E,ALTUNKAYNAK B,AYDIN M,Aydin N,VURALER Ö,ÜNAL B Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. . 2010; 438 - 445.
Vancouver	ÖZBEK E,ALTUNKAYNAK B,AYDIN M,Aydin N,VURALER Ö,ÜNAL B Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. . 2010; 438 - 445.
IEEE	ÖZBEK E,ALTUNKAYNAK B,AYDIN M,Aydin N,VURALER Ö,ÜNAL B "Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study." , ss.438 - 445, 2010.
ISNAD	ÖZBEK, Elvan vd. "Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study". (2010), 438-445.

APA	ÖZBEK E, ALTUNKAYNAK B, AYDIN M, Aydin N, VURALER Ö, ÜNAL B (2010). Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. Journal of Neurological Sciences (Turkish), 27(4), 438 - 445.
Chicago	ÖZBEK Elvan,ALTUNKAYNAK B. Zuhal,AYDIN Mehmet D.,Aydin Nazan,VURALER ÖZGEN,ÜNAL Bünyamin Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. Journal of Neurological Sciences (Turkish) 27, no.4 (2010): 438 - 445.
MLA	ÖZBEK Elvan,ALTUNKAYNAK B. Zuhal,AYDIN Mehmet D.,Aydin Nazan,VURALER ÖZGEN,ÜNAL Bünyamin Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. Journal of Neurological Sciences (Turkish), vol.27, no.4, 2010, ss.438 - 445.
AMA	ÖZBEK E,ALTUNKAYNAK B,AYDIN M,Aydin N,VURALER Ö,ÜNAL B Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. Journal of Neurological Sciences (Turkish). 2010; 27(4): 438 - 445.
Vancouver	ÖZBEK E,ALTUNKAYNAK B,AYDIN M,Aydin N,VURALER Ö,ÜNAL B Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study. Journal of Neurological Sciences (Turkish). 2010; 27(4): 438 - 445.
IEEE	ÖZBEK E,ALTUNKAYNAK B,AYDIN M,Aydin N,VURALER Ö,ÜNAL B "Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study." Journal of Neurological Sciences (Turkish), 27, ss.438 - 445, 2010.
ISNAD	ÖZBEK, Elvan vd. "Haloperidol-induced neuronal damage in guinea pig hippocampus: A microscopic study". Journal of Neurological Sciences (Turkish) 27/4 (2010), 438-445.