Yıl: 2024 Cilt: 16 Sayı: 1 Sayfa Aralığı: 11 - 19 Metin Dili: İngilizce DOI: 10.18521/ktd.1373002 İndeks Tarihi: 02-04-2024

Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases

Öz:
Objective: Annexin A1(AnxA1) is an anti-inflammatory mediator. In the current study,we aimed to evaluate whether or not serum Annexin A1 levels of inflammatory boweldiseases (IBDs) patients relate to the clinical and laboratory traits of IBDs. Methods: This case-control study included 67 ulcerative colitis (UC) patients (47 males and 20 females), 53 Crohn’s disease (CD) patients (37 males and 16 females) and 60 healthy controls (36 males and 24 females). The Mayo Clinical scoring system (MCS) was used for UC and the histological activity index (HAI) was determined by Truelove and Richards method. The Crohn's disease activity index (CDAI) was used for CD patients. Montreal classification was used for the localization of IBDs. Results: The mean serum AnxA1 concentrations were not statistically significant in UC, CD and the control groups (26.36±17.30 ng/ml vs 22.98±12.74 vs 24.45±12.18 ng/ml respectively, p=0.404). The MCS, HAI of UC patients negatively correlated with the serum AnxA1 values (rho=-0.616, p
Anahtar Kelime: Ulcerative colitis Crohn's disease Annexin A1 activity

İnflamatuvar Bağırsak Hastalıklarında Serum Annexin A1 Düzeylerinin Değerlendirilmesi

Öz:
Amaç: Annexin A1 (AnxA1) anti-inflamatuar bir moleküldür. Çalışmamızda, inflamatuar barsak hastalıklarında (İBH) serum Annexin A1 düzeylerinin hastalıkların klinik ve laboratuvar özellikleri ile ilişkili olup olmadığı araştırılmıştır. Gereç ve Yöntem: Bu vaka-kontrol çalışmasına 67 ÜK hastası, 53 Crohn hastalığı (CH) hastası ve 60 sağlıklı kontrol dahil edilmiştir. ÜK klinik aktivitesi için Mayo klinik skorlama sistemi (MKS) kullanıldı, histolojik aktivite indeksi (HAİ) Truelove ve Richards yöntemiyle belirlendi. CH için Crohn hastalığı aktivite indeksi (CHAİ) kullanıldı. İBH lokalizasyonu için Montreal sınıflandırması kullanıldı. Bulgular: ÜK, CH ve kontrol grupları arasinda ortalama serum AnxA1 konsantrasyonları yönünden fark saptanmadı (26,36±17,30 ng/ml vs 22,98±12,74 vs 24,45±12,18 ng/ml, sırasıyla p=0,404). ÜK’de MKS, HAİ ve serum AnxA1 değerleri arasında negatif korelasyon tespit edildi (rho=-0,616, p
Anahtar Kelime: İnflamatuar bağırsak hastalığı Annexin A1

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Kucuk I, Yazgan Y, YILDIRIM İ, Akbas simsek T, Çakır Güney B, SALMANOĞLU M, Kaplan M (2024). Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. , 11 - 19. 10.18521/ktd.1373002
Chicago Kucuk Irfan,Yazgan Yusuf,YILDIRIM İDRİS,Akbas simsek Tugba,Çakır Güney Başak,SALMANOĞLU Musa,Kaplan Mustafa Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. (2024): 11 - 19. 10.18521/ktd.1373002
MLA Kucuk Irfan,Yazgan Yusuf,YILDIRIM İDRİS,Akbas simsek Tugba,Çakır Güney Başak,SALMANOĞLU Musa,Kaplan Mustafa Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. , 2024, ss.11 - 19. 10.18521/ktd.1373002
AMA Kucuk I,Yazgan Y,YILDIRIM İ,Akbas simsek T,Çakır Güney B,SALMANOĞLU M,Kaplan M Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. . 2024; 11 - 19. 10.18521/ktd.1373002
Vancouver Kucuk I,Yazgan Y,YILDIRIM İ,Akbas simsek T,Çakır Güney B,SALMANOĞLU M,Kaplan M Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. . 2024; 11 - 19. 10.18521/ktd.1373002
IEEE Kucuk I,Yazgan Y,YILDIRIM İ,Akbas simsek T,Çakır Güney B,SALMANOĞLU M,Kaplan M "Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases." , ss.11 - 19, 2024. 10.18521/ktd.1373002
ISNAD Kucuk, Irfan vd. "Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases". (2024), 11-19. https://doi.org/10.18521/ktd.1373002
APA Kucuk I, Yazgan Y, YILDIRIM İ, Akbas simsek T, Çakır Güney B, SALMANOĞLU M, Kaplan M (2024). Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. KONURALP TIP DERGİSİ, 16(1), 11 - 19. 10.18521/ktd.1373002
Chicago Kucuk Irfan,Yazgan Yusuf,YILDIRIM İDRİS,Akbas simsek Tugba,Çakır Güney Başak,SALMANOĞLU Musa,Kaplan Mustafa Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. KONURALP TIP DERGİSİ 16, no.1 (2024): 11 - 19. 10.18521/ktd.1373002
MLA Kucuk Irfan,Yazgan Yusuf,YILDIRIM İDRİS,Akbas simsek Tugba,Çakır Güney Başak,SALMANOĞLU Musa,Kaplan Mustafa Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. KONURALP TIP DERGİSİ, vol.16, no.1, 2024, ss.11 - 19. 10.18521/ktd.1373002
AMA Kucuk I,Yazgan Y,YILDIRIM İ,Akbas simsek T,Çakır Güney B,SALMANOĞLU M,Kaplan M Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. KONURALP TIP DERGİSİ. 2024; 16(1): 11 - 19. 10.18521/ktd.1373002
Vancouver Kucuk I,Yazgan Y,YILDIRIM İ,Akbas simsek T,Çakır Güney B,SALMANOĞLU M,Kaplan M Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases. KONURALP TIP DERGİSİ. 2024; 16(1): 11 - 19. 10.18521/ktd.1373002
IEEE Kucuk I,Yazgan Y,YILDIRIM İ,Akbas simsek T,Çakır Güney B,SALMANOĞLU M,Kaplan M "Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases." KONURALP TIP DERGİSİ, 16, ss.11 - 19, 2024. 10.18521/ktd.1373002
ISNAD Kucuk, Irfan vd. "Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases". KONURALP TIP DERGİSİ 16/1 (2024), 11-19. https://doi.org/10.18521/ktd.1373002