The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation

ÜNSAL, Diclehan; ERPOLAT PETEK, O.; BORA, Hüseyin; AKMANSU, Müge; Göksel, Fatih; KARAHACIOĞLU, Eray

The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation

Müge AKMANSU, (Gazi Üniversitesi, Tıp Fakültesi, Radyasyon Onkoloji Anabilim Dalı, Ankara, Türkiye)

Fatih GÖKSEL, (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Radyasyon Onkolojisi Kliniği, Erzurum, Türkiye)

O. ERPOLAT PETEK, (Gazi Üniversitesi, Tıp Fakültesi, Radyasyon Onkoloji Anabilim Dalı, Ankara, Türkiye)

Diclehan ÜNSAL, (Gazi Üniversitesi, Tıp Fakültesi, Radyasyon Onkoloji Anabilim Dalı, Ankara, Türkiye)

Eray KARAHACIOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Radyasyon Onkoloji Anabilim Dalı, Ankara, Türkiye)

Hüseyin BORA (Gazi Üniversitesi, Tıp Fakültesi, Radyasyon Onkoloji Anabilim Dalı, Ankara, Türkiye)

Uluslararası Hematoloji-Onkoloji Dergisi

1 1

Yıl: 2011 Cilt: 21 Sayı: 3 Sayfa Aralığı: 147 - 152 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation

Öz:

Ayak bölgesinde (ayak parmakları, dorsum pedis, plantar pedis, regio calcanea) klasik Kaposi sarkomu bulunan hastaların yaﬂam ka- litesi; yürürken veya ayakkabı giyerken çektikleri acı nedeniyle bozulmaktadır. Bu hasta grubunda sıklıkla kullanılan radyoterapi, farklı doz ve fraksiyon ﬂemaları ile uygulanmaktadır. Ayağın klasik Kaposi sarkomunun radyoterapi tekniklerini optimize etmek için radyas- yonun yanıtını ve toksisitesini değerlendiren veri azdır. Çalıﬂmanın amacı bu hastalar için radyoterapinin etkinliğini ve güvenilirliğini de- ğerlendirmektir. 1999 ve 2005 yılları arasında tedavi olmuﬂ ve ayak bölgesindeki Kaposi sarkomu histolojik olarak doğrulanmıﬂ 15 hastanın 31 tedavi bölgesi retrospektif olarak değerlendirilmiﬂtir. Erkek/kadın oranı 2.75/1’dir, medyan yaﬂ 63’tür. En sık kullanılan radyoterapi ﬂeması 10 fraksiyonda 3000 cGy’dir. Medyan izlem süresi 68.4 aydır. Otuz tedavi alanı için 6, 12. aylardaki ve 5.yıldaki tam yanıt oranı sırayla %87, 93.3%, 93.3%’tür. Akut komplikasyonlar 17 (%54.8) tedavi alanında gözlenmiﬂtir. Tedaviye bağ- lı geliﬂen yan etkilerin tümü destek tedavi ile kontrol altına alınmıﬂtır. Radyoterapi sonrası 2-4 hafta içinde normal ayak hareketleri sağ- lanmıﬂtır. Radyoterapi ayak bölgesinin Kaposi sarkomu için etkili ve güvenli bir tedavi modalitesidir. Radyasyona ilk yanıt genellikle ha- yal kırıklığı yaratır ve ayaktaki ﬂikayetler radyasyonun akut toksisitesine bağlı artsa da, bu durum destek tedaviyle tamamen iyileﬂebilir

Anahtar Kelime:

Konular: Onkoloji

Ayak bölgesinin klasik kaposi sarkomunun palyatif radyoterapisi: retrospektif değerlendirme

Öz:

The life quality of the patients with classic Kaposi’s sarcoma exit in the foot region (toes, dorsum pedis, plantar pedis and region calcaneus) were impaired due to the walking or the pain while wearing shoes. The widely used radiotherapy in this patient group is applied with different doses and fractionation schemes. The data is limited for evaluating response and to- xicity of radiation to optimized radiotherapy techniques of foot’ CKS. The aim of the study was to assess the effectiveness and safety of RT for these patients. Thirty-one therapy areas of 15 patients with histological confirmed Kaposi’s sarcoma in the foot region and treated between 1999 and 2005 were evaluated retrospectively. The male/female ratio was 2.75/1 and the median age was 63 years of age. The most frequently used radiotherapy scheme was 3000cGy in 10 fractions.The median follow-up time was 68.4 months. The complete response ratios were 86.7%, 93.3%, 93.3% for 30 therapy are- as at 6, 12 months and 5 years, consecutively. Acute complications were observed in 17 (54.8%) therapy areas. All side ef- fects developed due to the therapy were controlled with supportive treatment. Normal foot movements were ensured wit- hin 2-4 weeks after the radiotherapy. According to our results, the radiotherapy is effective and safe therapy modality for Ka- posi’s sarcoma of the foot region. However, the first response to radiation is usually frustrating and it may increase the pa- tients’ complaint about the foot due to the acute toxicity. This can be improved completely with supportive therapy.

Anahtar Kelime:

Konular: Onkoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Kaposi M. Idiopathisches multiples pigmentsarcom der haut. Arch Dermatol Syphilol 4: 265, 1892.
2. Weissmann A, Linn S, Weltfriend S, Friedman-Birnba um R. Epidemiological study of classic Kaposi’s sarco ma: a retrospective review of 125 cases from Northern Israel. J Eur Acad Dermatol Venereol 14: 91-95, 2000.
3. Di Lorenzo G. Update on classic Kaposi sarcoma the rapy: new look at an old disease. Crit Rev Oncol He matol 68: 242-249, 2008
4. Hauerstock D, Gerstein W, Vuong T. Results of radiati on therapy for treatment of classic Kaposi sarcoma. J Cutan Med Surg 13: 18-21, 2009.
5. Berson AM, Quivey JM, Harris JW, Wara WM. Radiati on therapy for AIDS-related Kaposi's sarcoma. Int J Radiat Oncol Biol Phys 19: 569-575, 1990.
6. Cooper JS, Steinfeld AD, Lerch IA. Intentions and out comes in the radiotherapeutic management of epide mic Kaposi's sarcoma. Int J Radiat Oncol Biol Phys 20: 419-422, 1991.
7. Langtry JA, Bottomley DM, Philips RH, Staughton RC. The infra-red coagulator in the treatment of AIDS-rela ted Kaposi's sarcoma and a comparison with radiot herapy. Clin Exp Dermatol 19:23-25, 1994.
8. Safai B. AIDS-related Kaposi's sarcoma: therapy opti ons for today and tomorrow. Oncology 10: 1-38, 1996.
9. Gressen EL, Rosenstock JG, Xie Y, Corn BW. Palliati ve Treatment of Epidemic Kaposi Sarcoma of the Fe et. Am J Clin Oncol 22: 286-290, 1999.
10. Stein ME, Lakier R, Spencer D, et al. Radiation therapy for non-AIDS associated (classic and endemic African) and epidemic Kaposi's sarcoma. Int J Radiat Oncol Bi ol Phys 28: 613-619, 1994 Chang LF, Reddy S, Shidnia H. Comparison of radiati on therapy of classic and epidemic Kaposi's sarcoma. Am J Clin Oncol 15: 200-206, 1992.
12. Lo TC, Salzman FA, Smedal MI, Wright KA. Radiot herapy for Kaposi's sarcoma. Cancer 45: 684-687, 1980.
13. Holecek MJ, Harwood A. Radiotherapy of Kaposi’s sarcoma. Cancer 41: 1733-1738, 1978.
14. Cohen L. Dose time and volume parameters in radia tion therapy of kaposi’s sarcoma. Br J Radiol 35: 485 489, 1962.
15. Cohen L, Palmer PE, Nickson JJ. Treatment of Kaposi's sarcoma by radiation. Acta Unio Int Contra Cancrum 18: 502-509, 1962.
16. Yildiz F, Genc M, Akyurek M, et al. Radiotherapy in the management of Kaposi’s sarcoma: Comparison of 8 Gy versus 6 Gy. J Natl Med Assoc 98: 1136-1139, 2006.
17. Harrison M, Harrington KJ, Tomlinson DR, Stewart JS. Response and cosmetic outcome of two fractionation regimens for AIDS-related Kaposi's sarcoma. Radiot her Oncol 46: 23-28, 1998.
18. Cooper JS, Steinfeld AD, Lerch IA. The prognostic sig nificance of residual pigmentation following radiot herapy of epidemic Kaposi's sarcoma. J Clin Oncol 7: 619-621, 1989.
19. Stelzer KJ, Griffin TW. A randomized prospective trial of radiation therapy for AIDS-associated Kaposi's sar coma. Int J Radiat Oncol Biol Phys 27: 1057-1061, 1993.
20. Donahue BR, Cooper JS. Malignant neoplasms as sociated with the acquired immunodeficiency syn drome. In: Principle and Practice of Radiation On cology. Perez CA, Brady LW, Halperin EC, Schmidt Ullrich RK (eds). Philadelphia, Lippincott Williams and Wilkins, 5th ed. 2008: 702-716
21. Caccialanza M, Marca S, Piccinno R, Eulisse G. Radiotherapy of classic and human immunodeficiency virus-related Kaposi’s sarcoma: results in 1482 lesions. JEADV 22: 297-302, 2008.
22. Cooper JS, Fried PR. Defining the role of radiation therapy in the management of epidemic Kaposi's sar coma. Int J Radiat Oncol Biol Phys 13: 35-39, 1987.
23. Chak LY, Gill PS, Levine AM, et al. Radiation therapy for acquired immunodeficiency syndrome-related Kaposi's sarcoma. J Clin Oncol 6: 863-867, 1988.

APA	AKMANSU M, Göksel F, ERPOLAT PETEK O, ÜNSAL D, KARAHACIOĞLU E, BORA H (2011). The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. , 147 - 152.
Chicago	AKMANSU Müge,Göksel Fatih,ERPOLAT PETEK O.,ÜNSAL Diclehan,KARAHACIOĞLU Eray,BORA Hüseyin The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. (2011): 147 - 152.
MLA	AKMANSU Müge,Göksel Fatih,ERPOLAT PETEK O.,ÜNSAL Diclehan,KARAHACIOĞLU Eray,BORA Hüseyin The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. , 2011, ss.147 - 152.
AMA	AKMANSU M,Göksel F,ERPOLAT PETEK O,ÜNSAL D,KARAHACIOĞLU E,BORA H The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. . 2011; 147 - 152.
Vancouver	AKMANSU M,Göksel F,ERPOLAT PETEK O,ÜNSAL D,KARAHACIOĞLU E,BORA H The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. . 2011; 147 - 152.
IEEE	AKMANSU M,Göksel F,ERPOLAT PETEK O,ÜNSAL D,KARAHACIOĞLU E,BORA H "The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation." , ss.147 - 152, 2011.
ISNAD	AKMANSU, Müge vd. "The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation". (2011), 147-152.

APA	AKMANSU M, Göksel F, ERPOLAT PETEK O, ÜNSAL D, KARAHACIOĞLU E, BORA H (2011). The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. Uluslararası Hematoloji-Onkoloji Dergisi, 21(3), 147 - 152.
Chicago	AKMANSU Müge,Göksel Fatih,ERPOLAT PETEK O.,ÜNSAL Diclehan,KARAHACIOĞLU Eray,BORA Hüseyin The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. Uluslararası Hematoloji-Onkoloji Dergisi 21, no.3 (2011): 147 - 152.
MLA	AKMANSU Müge,Göksel Fatih,ERPOLAT PETEK O.,ÜNSAL Diclehan,KARAHACIOĞLU Eray,BORA Hüseyin The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. Uluslararası Hematoloji-Onkoloji Dergisi, vol.21, no.3, 2011, ss.147 - 152.
AMA	AKMANSU M,Göksel F,ERPOLAT PETEK O,ÜNSAL D,KARAHACIOĞLU E,BORA H The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. Uluslararası Hematoloji-Onkoloji Dergisi. 2011; 21(3): 147 - 152.
Vancouver	AKMANSU M,Göksel F,ERPOLAT PETEK O,ÜNSAL D,KARAHACIOĞLU E,BORA H The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation. Uluslararası Hematoloji-Onkoloji Dergisi. 2011; 21(3): 147 - 152.
IEEE	AKMANSU M,Göksel F,ERPOLAT PETEK O,ÜNSAL D,KARAHACIOĞLU E,BORA H "The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation." Uluslararası Hematoloji-Onkoloji Dergisi, 21, ss.147 - 152, 2011.
ISNAD	AKMANSU, Müge vd. "The palliative radiotherapy of classic kaposi’s sarcoma of foot region: retrospective evaluation". Uluslararası Hematoloji-Onkoloji Dergisi 21/3 (2011), 147-152.