The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population

HAZAR, Abdussemet; GÖZ, Mustafa; DİLMEÇ, FUAT; AYDIN, MEHMET SALIH; DEMİRKOL, Abbas Heval; Koçarslan, Aydemir

The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population

Abdussemet HAZAR, (Harran Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerraisi Anabilim Dalı, Şanlıurfa, Türkiye)

Fuat DİLMEÇ, (Harran Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Şanlıurfa, Türkiye)

Mustafa GÖZ, (Harran Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerraisi Anabilim Dalı, Şanlıurfa, Türkiye)

Aydemir KOÇARSLAN, (Harran Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerraisi Anabilim Dalı, Şanlıurfa, Türkiye)

Mehmet Salih AYDIN, (Harran Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerraisi Anabilim Dalı, Şanlıurfa, Türkiye)

Abbas Heval DEMİRKOL (Harran Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerraisi Anabilim Dalı, Şanlıurfa, Türkiye)

Turkish Journal of Medical Sciences

2 2

Yıl: 2011 Cilt: 41 Sayı: 5 Sayfa Aralığı: 895 - 902 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population

Öz:

Amaç: Arteriyoskleroze sebep veya katkı yapan birçok farklı genetik ve kliniksel faktör, tanımlanmıştır. Koroner arter hastalığı (KAH), hipertansiyon ve diyabet gibi karmaşık hastalıklar, çoğunlukla çeşitli genler, çevresel faktörler ve bunlar arasındaki etkileşimlerin bireysel duyarlılığı sonucu oluşurlar. Paraksonaz 1 (PON1) enzimi, aterosklerozis ve KAH’ın patojenezinde rol oynar. Bu çalışmanın amacı, PON1 geni c.163T>A ve c.575A>G polimorfizmleri ile KAH arasındaki ilişkiyi araştırmak ve Güneydoğu Türk toplumunda PON1 geni özel polimorfizmleri ile KAH arasında ilişkinin olup olmadığını belirlemektir. Yöntem ve gereç: Çalışmaya KAH’lı 61 hasta ile sağlıklı 103 birey dahil edildi ve bunların DNA’ları elde edildi. KAH vakalarında PON1 geni (NM_000446.5, GI: 5444) c.163T>A (Hsp92IIT>A) ve c.575A>G (AlwIA>G) polimorfizm sıklıklarının belirlenmesinde polimeraz zincir reaksiyonu-restriksiyon parça uzunluk polimorfizmi (PCR-RFLP) tekniği kullanıldı. Bulgular: Sonuçlarımız, vücut kitle indeksi (BMI) (27,5 ± 5,7), düşük-yoğunluklu lipoprotein (LDL-C) (127,0 ± 45,8), diyabet (13,0) ve hipertansiyon (35,0) sıklıklarının KAH’lı hastalarda kontrol bireylerine (sırasıyla 25,9 ± 4,1; 105,6 ± 26,3; 2,0; ve 19,0) göre anlamlı şekilde yüksek olduğunu gösterdi (P < 0,05). KAH’lı hastaların PON1 geni c.163T>A ve c.575A>G genotip sıklıkları, sağlıklı bireylerle karşılaştırıldığında herhangi bir anlamlı farklılık bulunmadı (P > 0.05). Sonuç: PON1 geni c.163T>A ve c.575A>G polimorfizmleri, güneydoğu Türk toplumunda bu hastalık için önemli bir risk faktörü göstermedi.

Anahtar Kelime:

Konular: Cerrahi

Güneydoğu Türk toplumunda koroner arter hastalığında paraoxonaz (PON1) geni polimorfi zmleri

Öz:

Aim: To investigate the association between the paraoxonase 1 (PON1) c.163T>A and c.575A>G polymorphisms and coronary artery disease (CAD), and whether specific polymorphisms in the PON1 gene are associated with CAD in the southeastern Turkish population. Many diff erent genetic and clinical factors have been identifi ed as causes or contributors to atherosclerosis. Complex diseases such as CAD, hypertension, and diabetes are usually caused by an individual’s susceptibility to various genes, environmental factors, and the interactions between them. The PON1 enzyme has been implicated in the pathogenesis of atherosclerosis and CAD. Materials and methods: Enrolled in this study were 61 patients with CAD and 103 healthy individuals; their DNA was isolated. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the frequencies of the PON1 gene (NM_000446.5, GI: 5444) c.163T>A (Hsp92IIT>A) and c.575A>G (AlwIA>G) polymorphisms in CAD cases. Results: Our data indicated that the body mass index (BMI) (27.5 ± 5.7), low-density lipoprotein (LDL-C) values (127.0 ± 45.8), and frequencies of diabetes (13.0) and hypertension (35.0) were signifi cantly higher in CAD patients than in the control subjects (25.9 ± 4.1; 105.6 ± 26.3; 2.0; and 19.0, respectively) (P < 0.05). No significant differences were observed in the frequencies of the c.163T>A and c.575A>G genotypes of the PON1 gene in CAD patients compared to healthy individuals (P > 0.05). Conclusion: The PON1 gene c.163T>A and c.575A>G polymorphisms did not represent an important risk factor for this disease in the southeastern Turkish population.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	HAZAR A, DİLMEÇ F, GÖZ M, Koçarslan A, AYDIN M, DEMİRKOL A (2011). The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. , 895 - 902.
Chicago	HAZAR Abdussemet,DİLMEÇ FUAT,GÖZ Mustafa,Koçarslan Aydemir,AYDIN MEHMET SALIH,DEMİRKOL Abbas Heval The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. (2011): 895 - 902.
MLA	HAZAR Abdussemet,DİLMEÇ FUAT,GÖZ Mustafa,Koçarslan Aydemir,AYDIN MEHMET SALIH,DEMİRKOL Abbas Heval The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. , 2011, ss.895 - 902.
AMA	HAZAR A,DİLMEÇ F,GÖZ M,Koçarslan A,AYDIN M,DEMİRKOL A The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. . 2011; 895 - 902.
Vancouver	HAZAR A,DİLMEÇ F,GÖZ M,Koçarslan A,AYDIN M,DEMİRKOL A The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. . 2011; 895 - 902.
IEEE	HAZAR A,DİLMEÇ F,GÖZ M,Koçarslan A,AYDIN M,DEMİRKOL A "The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population." , ss.895 - 902, 2011.
ISNAD	HAZAR, Abdussemet vd. "The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population". (2011), 895-902.

APA	HAZAR A, DİLMEÇ F, GÖZ M, Koçarslan A, AYDIN M, DEMİRKOL A (2011). The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. Turkish Journal of Medical Sciences, 41(5), 895 - 902.
Chicago	HAZAR Abdussemet,DİLMEÇ FUAT,GÖZ Mustafa,Koçarslan Aydemir,AYDIN MEHMET SALIH,DEMİRKOL Abbas Heval The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. Turkish Journal of Medical Sciences 41, no.5 (2011): 895 - 902.
MLA	HAZAR Abdussemet,DİLMEÇ FUAT,GÖZ Mustafa,Koçarslan Aydemir,AYDIN MEHMET SALIH,DEMİRKOL Abbas Heval The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. Turkish Journal of Medical Sciences, vol.41, no.5, 2011, ss.895 - 902.
AMA	HAZAR A,DİLMEÇ F,GÖZ M,Koçarslan A,AYDIN M,DEMİRKOL A The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. Turkish Journal of Medical Sciences. 2011; 41(5): 895 - 902.
Vancouver	HAZAR A,DİLMEÇ F,GÖZ M,Koçarslan A,AYDIN M,DEMİRKOL A The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population. Turkish Journal of Medical Sciences. 2011; 41(5): 895 - 902.
IEEE	HAZAR A,DİLMEÇ F,GÖZ M,Koçarslan A,AYDIN M,DEMİRKOL A "The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population." Turkish Journal of Medical Sciences, 41, ss.895 - 902, 2011.
ISNAD	HAZAR, Abdussemet vd. "The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population". Turkish Journal of Medical Sciences 41/5 (2011), 895-902.