Keratokonüsün etiyopatogenezine güncel bir bakış

OR, Hilmi

Keratokonüsün etiyopatogenezine güncel bir bakış

Hilmi OR (Özel Muayenehane, İstanbul, Türkiye)

Türk Oftalmoloji Dergisi

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Yıl: 2011 Cilt: 41 Sayı: 5 Sayfa Aralığı: 339 - 347 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Keratokonüsün etiyopatogenezine güncel bir bakış

Öz:

Keratokonüsün etiyolojisi bilinmemektedir. Farklı etkenlerin etiyolojide ve patojenezde rol oynadığı gösterilmiştir. Hem genetik, hem de çevresel etkenlerin hastalığın oluşmasında rol oynadığı düşünülmektedir. Bugüne kadar yapılmış olan araştırmalar etiyolojinin çok nedenli bir fenotipik dışavurum olduğunu düşündürmektedir. Keratokonüsün olası genetik etkenlerini bulmak için çeşitli yönlerde araştırmalar yapılmaktadır: Keratokonüs ile beraber görülen hastalıkların incelenmesi, gen araştırmaları, protein ve enzim araştırmaları bu yönde yapılan çalışmalardan bazılarıdır. Hücre bazında son yıllarda yapılan araştırmalarda, oksidatif stres keratokonüsün fizyopatolojisinde ortaya çıkan ektatik değişikliğin nedeni olarak görülmektedir. Etiyolojide genetik etkenlerin dışında hormonlar ve hormonal dengeler araştırılmakta, kronik travma (kontakt lens kullanımı ve göz ovalama) olası neden olarak incelenmektedir.

Anahtar Kelime:

Konular: Göz Hastalıkları

An up-to-date view at the etiopathogenesis of keratoconus

Öz:

The etiology of keratoconus is unknown. Different factors have been shown to play a role in the etiology and pathogenesis. Both genetic and environmental factors are thought to play a role in the formation of the disease. The research studies that have been done so far suggest a multifactorial phenotypic expression. Research studies have been conducted to find the possible genetic factors for keratoconus in various aspects: Analysis of diseases coexisting with keratoconus, gene research, protein and enzyme studies are some of the studies in this direction. Recent research in the pathophysiology of keratoconus on the basis of cell has shown oxidative stress as a cause of ectatic changes. In the etiology apart from genetic factors, hormones and hormonal balances are investigated, as well as chronic trauma (contact lens use and eye rubbing) is examined as a possible cause.

Anahtar Kelime:

Konular: Göz Hastalıkları

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	OR H (2011). Keratokonüsün etiyopatogenezine güncel bir bakış. , 339 - 347.
Chicago	OR Hilmi Keratokonüsün etiyopatogenezine güncel bir bakış. (2011): 339 - 347.
MLA	OR Hilmi Keratokonüsün etiyopatogenezine güncel bir bakış. , 2011, ss.339 - 347.
AMA	OR H Keratokonüsün etiyopatogenezine güncel bir bakış. . 2011; 339 - 347.
Vancouver	OR H Keratokonüsün etiyopatogenezine güncel bir bakış. . 2011; 339 - 347.
IEEE	OR H "Keratokonüsün etiyopatogenezine güncel bir bakış." , ss.339 - 347, 2011.
ISNAD	OR, Hilmi. "Keratokonüsün etiyopatogenezine güncel bir bakış". (2011), 339-347.

APA	OR H (2011). Keratokonüsün etiyopatogenezine güncel bir bakış. Türk Oftalmoloji Dergisi, 41(5), 339 - 347.
Chicago	OR Hilmi Keratokonüsün etiyopatogenezine güncel bir bakış. Türk Oftalmoloji Dergisi 41, no.5 (2011): 339 - 347.
MLA	OR Hilmi Keratokonüsün etiyopatogenezine güncel bir bakış. Türk Oftalmoloji Dergisi, vol.41, no.5, 2011, ss.339 - 347.
AMA	OR H Keratokonüsün etiyopatogenezine güncel bir bakış. Türk Oftalmoloji Dergisi. 2011; 41(5): 339 - 347.
Vancouver	OR H Keratokonüsün etiyopatogenezine güncel bir bakış. Türk Oftalmoloji Dergisi. 2011; 41(5): 339 - 347.
IEEE	OR H "Keratokonüsün etiyopatogenezine güncel bir bakış." Türk Oftalmoloji Dergisi, 41, ss.339 - 347, 2011.
ISNAD	OR, Hilmi. "Keratokonüsün etiyopatogenezine güncel bir bakış". Türk Oftalmoloji Dergisi 41/5 (2011), 339-347.