Yıl: 2024 Cilt: 35 Sayı: 2 Sayfa Aralığı: 143 - 149 Metin Dili: İngilizce DOI: 10.5152/tjg.2024.22769 İndeks Tarihi: 10-06-2024

Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets

Öz:
Background/Aims: Hepatocellular carcinoma is the main type of primary liver cancer. Macroscopic vascular invasion is usually identified during imaging, whereas microvascular invasion is usually determined by histopathological evaluation. We aim to identify the associa- tion between microvascular invasion and other markers of tumor aggressiveness and to identify the role of microvascular invasion in the prognosis of patients who were treated by liver transplantation for hepatocellular carcinoma. Materials and Methods: This is a single-center retrospective analysis of prospectively collected data. Patients who received liver trans- plantation for hepatocellular carcinoma were included in the study. Data were collected regarding sociodemographic variables, crite- ria of selection for liver transplantation, pretransplant alpha-fetoprotein, presence or absence of microvascular invasion, presence or absence of recurrence, overall survival, and disease-free survival. Data were analyzed using Statistical Package for the Social Sciences. Results: Sociodemographic laboratory values and radiologic tumor characteristics were found to be similar in patients with or without microvascular invasion. Our study revealed that microvascular invasion is associated with increased recurrence, decreased diseased- free survival, and decreased overall survival, only for patients with hepatocellular carcinoma beyond Milan criteria at the time of liver transplantation. Conclusion: For patients beyond Milan criteria, but not within Milan criteria, microvascular invasion plays a significant role in predicting recurrence and shorter survival after liver transplantation.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Garzali I, Carr B, ince v, Isik B, AKATLI A (2024). Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. , 143 - 149. 10.5152/tjg.2024.22769
Chicago Garzali Ibrahim Umar,Carr Brian,ince volkan,Isik Burak,AKATLI Ayse Nur Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. (2024): 143 - 149. 10.5152/tjg.2024.22769
MLA Garzali Ibrahim Umar,Carr Brian,ince volkan,Isik Burak,AKATLI Ayse Nur Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. , 2024, ss.143 - 149. 10.5152/tjg.2024.22769
AMA Garzali I,Carr B,ince v,Isik B,AKATLI A Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. . 2024; 143 - 149. 10.5152/tjg.2024.22769
Vancouver Garzali I,Carr B,ince v,Isik B,AKATLI A Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. . 2024; 143 - 149. 10.5152/tjg.2024.22769
IEEE Garzali I,Carr B,ince v,Isik B,AKATLI A "Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets." , ss.143 - 149, 2024. 10.5152/tjg.2024.22769
ISNAD Garzali, Ibrahim Umar vd. "Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets". (2024), 143-149. https://doi.org/10.5152/tjg.2024.22769
APA Garzali I, Carr B, ince v, Isik B, AKATLI A (2024). Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. Turkish Journal of Gastroenterology, 35(2), 143 - 149. 10.5152/tjg.2024.22769
Chicago Garzali Ibrahim Umar,Carr Brian,ince volkan,Isik Burak,AKATLI Ayse Nur Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. Turkish Journal of Gastroenterology 35, no.2 (2024): 143 - 149. 10.5152/tjg.2024.22769
MLA Garzali Ibrahim Umar,Carr Brian,ince volkan,Isik Burak,AKATLI Ayse Nur Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. Turkish Journal of Gastroenterology, vol.35, no.2, 2024, ss.143 - 149. 10.5152/tjg.2024.22769
AMA Garzali I,Carr B,ince v,Isik B,AKATLI A Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. Turkish Journal of Gastroenterology. 2024; 35(2): 143 - 149. 10.5152/tjg.2024.22769
Vancouver Garzali I,Carr B,ince v,Isik B,AKATLI A Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets. Turkish Journal of Gastroenterology. 2024; 35(2): 143 - 149. 10.5152/tjg.2024.22769
IEEE Garzali I,Carr B,ince v,Isik B,AKATLI A "Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets." Turkish Journal of Gastroenterology, 35, ss.143 - 149, 2024. 10.5152/tjg.2024.22769
ISNAD Garzali, Ibrahim Umar vd. "Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets". Turkish Journal of Gastroenterology 35/2 (2024), 143-149. https://doi.org/10.5152/tjg.2024.22769