Yıl: 2024 Cilt: 44 Sayı: 2 Sayfa Aralığı: 60 - 68 Metin Dili: İngilizce DOI: 10.5336/medsci.2023-100684 İndeks Tarihi: 10-06-2024

An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice

Öz:
Objective: Exercise is known to have many beneficial effects for the organism, especially the musculoskeletal, cardiovascu- lar, respiratory and endocrine systems, depending on the type, inten- sity, duration and frequency. One of the mechanisms that mediate these beneficial effects is cytokines released from muscle called myokines. It is important to examine myokine levels in response to exercise to un- derstand their roles in muscle growth / differentiation, metabolism, an- giogenesis, neuronal stimulation. We aimed to investigate the time-dependent changes in the plasma levels of ciliary neurotrophic factor (CNTF), CXC ligand 1 (CXCL-1), cardiotrophin 1 (CT-1), on- costatin M (OSM), myostatin (MSTN) in response to acute-chronic swimming exercise in mice. Material and Methods: 70 adult, BALB/c male mice were divided into control, acute swimming (30 min) and chronic swimming (30 min/day, 5 days/week, 6 weeks) groups. Exercising mice were further divided into 3, in terms of the time passed (3, 24, 48 h) following the last exercise session. Mice swam in a water tank (68 cm x 44 cm x 38 cm) at constant tempera- ture (30-32 °C). Plasma CNTF, CXCL-1, CT-1, OSM, MSTN levels were determined using commercial kits. Results: No statistically sig- nificant time-dependent alteration in plasma levels of CNTF, CXCL- 1, CT-1, OSM, MSTN was determined. Conclusion: The fact that there is no change in plasma myokine concentrations at 3, 24 and 48 h following exercises may not exclude the possibility that these myokines play role in exercise-induced adaptations. If different sam- ple collection times had been chosen, possible changes in these myokines may have been detected.
Anahtar Kelime: Adaptation myokine swimming

Farelerde Akut ve Kronik Yüzme Egzersizine Miyokin Cevaplarının İncelenmesi Üzerine Deneysel Bir Çalışma

Öz:
Amaç: Egzersizin; tipine, şiddetine, süresine ve sıklığına bağlı olarak başta kas-iskelet sistemi, kardiyovasküler sistem, solunum sis- temi, endokrin sistem olmak üzere organizma için çok say ıda yararlı etkileri olduğu bilinmektedir. Egzersizin bu faydal ı etkilerine aracılık eden mekanizmalardan birisi de miyokin adı verilen kastan salınan si- tokinlerdir. Miyokinlerin kas büyüme / farkl ılaşması, metabolizması, yeni damar olu şumu ve kas ın sinirsel uyar ımındaki rollerini anlamak için egzersize cevaben düzeylerinin incelenmesi önem kazanmaktadır. Bu çalışmada, farelerde akut-kronik yüzme egzersizine yanıt olarak si- liyer nörotrofik faktör [ciliary neurotrophic factor (CNTF)], CXC li- gand 1 (CXCL-1), kardiyotrofin 1 [cardiotrophin 1 (CT-1)], onkostatin M (OSM), miyostatin (MSTN) miyokinlerinin plazma düzeylerindeki zamana bağlı değişimlerin araştırılması amaçlandı. Gereç ve Yöntem- ler: 70 adet yetişkin, BALB/c erkek fare; kontrol, akut yüzme (30 dk) ve kronik yüzme (30 dk/gün, 5 gün/hafta, 6 hafta) gruplar ına ayrıldı. Egzersiz yapan fareler, son egzersiz seansından sonra geçen süreye göre (3, 24, 48 saat) ayrıca 3’e bölündü. Fareler, su tankında (68 cm x 44 cm x 38 cm), sabit s ıcaklıkta (30-32 °C) yüzdürüldü. Plazma CNTF, CXCL-1, CT-1, OSM ve MSTN düzeyleri ticari kitler kullanılarak öl- çüldü. Bulgular: CNTF, CXCL-1, CT-1, OSM, MSTN’nin plazma dü- zeylerinde zamana ba ğlı istatistiksel olarak anlaml ı bir de ğişiklik saptanmadı. Sonuç: Egzersiz sonrası 3, 24 ve 48. saatlerde plazma mi- yokin konsantrasyonlarında herhangi bir de ğişiklik olmaması, bu mi- yokinlerin egzersize ba ğlı adaptasyonlarda rol oynama olas ılığını dışlamayabilir. Farklı numune toplama zamanları seçilseydi bu miyo- kinlerdeki olası değişiklikler tespit edilebilirdi.
Anahtar Kelime: Adaptasyon miyokin yüzme

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA TUZCU E, Kilic-Erkek O, BOR-KUCUKATAY M (2024). An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. , 60 - 68. 10.5336/medsci.2023-100684
Chicago TUZCU EGEM BURCU,Kilic-Erkek Ozgen,BOR-KUCUKATAY Melek An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. (2024): 60 - 68. 10.5336/medsci.2023-100684
MLA TUZCU EGEM BURCU,Kilic-Erkek Ozgen,BOR-KUCUKATAY Melek An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. , 2024, ss.60 - 68. 10.5336/medsci.2023-100684
AMA TUZCU E,Kilic-Erkek O,BOR-KUCUKATAY M An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. . 2024; 60 - 68. 10.5336/medsci.2023-100684
Vancouver TUZCU E,Kilic-Erkek O,BOR-KUCUKATAY M An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. . 2024; 60 - 68. 10.5336/medsci.2023-100684
IEEE TUZCU E,Kilic-Erkek O,BOR-KUCUKATAY M "An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice." , ss.60 - 68, 2024. 10.5336/medsci.2023-100684
ISNAD TUZCU, EGEM BURCU vd. "An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice". (2024), 60-68. https://doi.org/10.5336/medsci.2023-100684
APA TUZCU E, Kilic-Erkek O, BOR-KUCUKATAY M (2024). An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. Türkiye Klinikleri Tıp Bilimleri Dergisi, 44(2), 60 - 68. 10.5336/medsci.2023-100684
Chicago TUZCU EGEM BURCU,Kilic-Erkek Ozgen,BOR-KUCUKATAY Melek An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. Türkiye Klinikleri Tıp Bilimleri Dergisi 44, no.2 (2024): 60 - 68. 10.5336/medsci.2023-100684
MLA TUZCU EGEM BURCU,Kilic-Erkek Ozgen,BOR-KUCUKATAY Melek An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. Türkiye Klinikleri Tıp Bilimleri Dergisi, vol.44, no.2, 2024, ss.60 - 68. 10.5336/medsci.2023-100684
AMA TUZCU E,Kilic-Erkek O,BOR-KUCUKATAY M An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2024; 44(2): 60 - 68. 10.5336/medsci.2023-100684
Vancouver TUZCU E,Kilic-Erkek O,BOR-KUCUKATAY M An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2024; 44(2): 60 - 68. 10.5336/medsci.2023-100684
IEEE TUZCU E,Kilic-Erkek O,BOR-KUCUKATAY M "An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice." Türkiye Klinikleri Tıp Bilimleri Dergisi, 44, ss.60 - 68, 2024. 10.5336/medsci.2023-100684
ISNAD TUZCU, EGEM BURCU vd. "An Experimental Study on Investigation of Myokine Responses to Acute and Chronic Swimming Exercise in Mice". Türkiye Klinikleri Tıp Bilimleri Dergisi 44/2 (2024), 60-68. https://doi.org/10.5336/medsci.2023-100684