Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients

Yıl: 2024 Cilt: 20 Sayı: 1 Sayfa Aralığı: 28 - 34 Metin Dili: İngilizce DOI: 10.4274/BMJ.galenos.2023.2022.6-1 İndeks Tarihi: 10-06-2024

Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients

Öz:
Objective: To evaluate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the tear and conjunctival secretions of laboratory-confirmed coronavirus disease-2019 (COVID-19) patients. Methods: A total of 152 consecutive COVID-19 patients, confirmed by real-time polymerase chain reaction (RT-PCR) test in nasopharyngeal swabs, were included. The conjunctival swabs were taken from both eyes by the same ophthalmologist in the first 24-36 hours after positive test results for COVID-19 in the nasopharyngeal swabs were detected. Results: Of the 152 patients, 96 (63.15%) were male and 56 (36.85%) were female. The mean age was 39.36±13.15 years. Sixteen (10.5%) patients had symptoms or findings such as tearing, stinging, redness, pain, and burning in their eyes. RT-PCR tests for SARS-CoV-2 RNA in conjunctival swabs were positive in 13 (8.55%) of 152 COVID-19 patients. Conclusion: This study showed that SARS-CoV-2 may be found in the conjunctival swabs of laboratory-confirmed COVID-19 patients, and ocular secretions may be a possible route for virus transmission.
Anahtar Kelime:

COVİD-19 Hastalarında Nazofariengeal Sürüntü PCR Pozitifliğinin Konjonktival Sürüntü PCR Pozitifliği ile Korelasyonu

Öz:
Amaç: Laboratuvar onaylı koronavirüs hastalığı-2019 (COVİD-19) hastalarının gözyaşı ve konjonktival sekresyonlarında şiddetli akut solunum sendromu koronavirüs 2 (SARS-CoV-2) varlığını değerlendirmektir. Gereç ve Yöntem: Nazofaringeal sürüntüde gerçek zamanlı polimeraz zincir reaksiyonu (RT-PCR) testi ile doğrulanan ardışık yüz elli iki COVİD-19 hastası dahil edildi. Nazofarengeal sürüntülerde COVİD-19 için pozitif test sonuçları tespit edildikten sonraki ilk 24-36 saat içinde aynı oftalmolog tarafından her iki gözden konjonktival sürüntüler alındı. Bulgular: Yüz elli iki hastanın 96’sı (%63,15) erkek, 56’sı (%36,85) kadındı. Ortalama yaş 39,36±13,15 idi. On altı (%10,5) hastanın gözlerinde yaşarma, batma, kızarıklık, ağrı, yanma gibi semptom veya bulgular vardı. Konjonktival sürüntülerde SARS-CoV-2 RNA için RT-PCR testleri, 152 COVİD-19 hastasının 13’ünde (%8,55) pozitif tespit edildi. Sonuç: Bu çalışma, laboratuvarca doğrulanmış COVİD-19 hastalarının konjonktival sürüntülerinde SARS-CoV-2’nin bulunabileceğini ve oküler sekresyonların virüs bulaşması için olası bir yol olabileceğini göstermiştir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Özbaş M, vural a, demirayak b, Karabela Y, KARABELA S, Zirtiloglu S, Küçüksümer Y, Yigit U, Kart Yaşar K (2024). Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. , 28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
Chicago Özbaş Mehmet,vural asli,demirayak bengi,Karabela Yunus,KARABELA Semsi Nur,Zirtiloglu Sibel,Küçüksümer Yaşar,Yigit Ulviye,Kart Yaşar Kadriye Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. (2024): 28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
MLA Özbaş Mehmet,vural asli,demirayak bengi,Karabela Yunus,KARABELA Semsi Nur,Zirtiloglu Sibel,Küçüksümer Yaşar,Yigit Ulviye,Kart Yaşar Kadriye Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. , 2024, ss.28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
AMA Özbaş M,vural a,demirayak b,Karabela Y,KARABELA S,Zirtiloglu S,Küçüksümer Y,Yigit U,Kart Yaşar K Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. . 2024; 28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
Vancouver Özbaş M,vural a,demirayak b,Karabela Y,KARABELA S,Zirtiloglu S,Küçüksümer Y,Yigit U,Kart Yaşar K Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. . 2024; 28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
IEEE Özbaş M,vural a,demirayak b,Karabela Y,KARABELA S,Zirtiloglu S,Küçüksümer Y,Yigit U,Kart Yaşar K "Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients." , ss.28 - 34, 2024. 10.4274/BMJ.galenos.2023.2022.6-1
ISNAD Özbaş, Mehmet vd. "Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients". (2024), 28-34. https://doi.org/10.4274/BMJ.galenos.2023.2022.6-1
APA Özbaş M, vural a, demirayak b, Karabela Y, KARABELA S, Zirtiloglu S, Küçüksümer Y, Yigit U, Kart Yaşar K (2024). Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. Bakırköy Tıp Dergisi, 20(1), 28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
Chicago Özbaş Mehmet,vural asli,demirayak bengi,Karabela Yunus,KARABELA Semsi Nur,Zirtiloglu Sibel,Küçüksümer Yaşar,Yigit Ulviye,Kart Yaşar Kadriye Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. Bakırköy Tıp Dergisi 20, no.1 (2024): 28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
MLA Özbaş Mehmet,vural asli,demirayak bengi,Karabela Yunus,KARABELA Semsi Nur,Zirtiloglu Sibel,Küçüksümer Yaşar,Yigit Ulviye,Kart Yaşar Kadriye Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. Bakırköy Tıp Dergisi, vol.20, no.1, 2024, ss.28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
AMA Özbaş M,vural a,demirayak b,Karabela Y,KARABELA S,Zirtiloglu S,Küçüksümer Y,Yigit U,Kart Yaşar K Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. Bakırköy Tıp Dergisi. 2024; 20(1): 28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
Vancouver Özbaş M,vural a,demirayak b,Karabela Y,KARABELA S,Zirtiloglu S,Küçüksümer Y,Yigit U,Kart Yaşar K Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients. Bakırköy Tıp Dergisi. 2024; 20(1): 28 - 34. 10.4274/BMJ.galenos.2023.2022.6-1
IEEE Özbaş M,vural a,demirayak b,Karabela Y,KARABELA S,Zirtiloglu S,Küçüksümer Y,Yigit U,Kart Yaşar K "Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients." Bakırköy Tıp Dergisi, 20, ss.28 - 34, 2024. 10.4274/BMJ.galenos.2023.2022.6-1
ISNAD Özbaş, Mehmet vd. "Correlation of Conjunctival Swab PCR Positivity with Nasopharyngeal Swab PCR Positivity in COVID-19 Patients". Bakırköy Tıp Dergisi 20/1 (2024), 28-34. https://doi.org/10.4274/BMJ.galenos.2023.2022.6-1