Yıl: 2024 Cilt: 20 Sayı: 1 Sayfa Aralığı: 48 - 54 Metin Dili: İngilizce DOI: 10.4274/BMJ.galenos.2023.2023.1-8 İndeks Tarihi: 10-06-2024

Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial

Öz:
Objective: Methyl alcohol, which is quite cheap compared to ethyl alcohol, can be used to produce imitated alcohol. For this reason, cases of methyl alcohol intoxication can be observed from time to time. Although it is rare, it is an emergency that needs to be diagnosed and treated early because of its high mortality. Methods: In this study, 22 patients aged ≥18 years who were admitted to the intensive care unit (ICU) due to methyl alcohol intoxication between 2015 and 2022 were included. The patients were divided into 2 groups, survivor and non-survivor, and compared retrospectively in terms of factors predicting mortality. Results: Except for one of the 22 patients included in the study, all patients developed methyl alcohol intoxication because of the use of imitated alcohol. Only one patient had a history of using perfume for suicidal purposes. Of the patients who developed methyl alcohol intoxication, 13 (59%) were in the non-survivor group and 9 (41%) were in the survivor group. While the rate of invasive mechanical ventilation needed before the ICU was 55.6% in the survivor group, it was 100% in the non-survivor group, and there was a statistically significant difference between them (p<0.017). In the non-survivor patient group, blood HCO3 and pH levels were found to be significantly lower after ICU admission (p=0.002, p=0.008). At the same time, blood creatinine, potassium, and total bilirubin levels were significantly higher (p=0.002, p=0.007, p<0.035). Acute physiology and chronic health evaluation-II and sequential organ failure assessment scores after ICU admission were also significantly higher in the non-survivor group than in the survivor group (p=0.005, p=0.035). Conclusion: It was determined that in patients who died due to methyl alcohol intoxication, deeper metabolic acidosis and irreversible multi- organ failure developed during the period until ICU admission. The acute physiology and chronic health evaluation-II and sequential organ failure assessment scores were both effective in predicting mortality.
Anahtar Kelime:

Metil Alkol İntoksikasyonunda Mortaliteyi Öngören Faktörler: Retrospektif Bir Klinik Çalışma

Öz:
Amaç: Etil alkole göre oldukça ucuz olan metil alkol, dolandırıcılar tarafından sahte alkol üretiminde kullanılabilmektedir. Bu nedenle zaman zaman metil alkol zehirlenmesi olguları görülebilmektedir. Nadir görülmekle birlikte mortalitesinin yüksek olması nedeniyle erken teşhis ve tedavi edilmesi gereken acil bir durumdur. Gereç ve Yöntem: Bu çalışmada 2015-2022 yılları arasında metil alkol intoksikasyonu nedeniyle yoğun bakım ünitesine (YBÜ) yatırılan ≥18 yaş 22 hasta çalışmaya dahil edildi. Hastalar sağ kalan ve sağ kalmayan olmak üzere 2 gruba ayrılarak mortaliteyi öngören faktörler açısından retrospektif olarak karşılaştırıldı. Bulgular: Çalışmaya dahil edilen 22 hastadan biri dışında tüm hastalarda sahte alkol kullanımı nedeniyle metil alkol intoksikasyonu gelişti. Sadece bir hastada intihar amaçlı parfüm kullanma öyküsü vardı. Metil alkol intoksikasyonu gelişen hastaların 13’ü (%59) sağ kalmayan grupta, 9’u (%41) sağ kalan grupta yer aldı. Sağ kalan grubunda YBÜ öncesi invaziv mekanik ventilasyon ihtiyacı oranı %55,6 iken, sağ kalmayan grupta %100’dü ve aralarında istatistiksel olarak anlamlı fark vardı (p=0,017). Sağ kalan grupta YBÜ’ye yatış sonrası kan HCO3 ve pH düzeyleri istatistiksel olarak anlamlı derecede düşük bulundu (p=0,002, p=0,008). Aynı zamanda kan kreatinin, potasyum ve total bilirubin düzeyleri istatistiksel olarak anlamlı derecede yüksekti (p=0,002, p=0,007, p<0,035). YBÜ’ye kabulü sonrası akut fizyoloji ve kronik sağlik değerlendirmesi-II ve sıralı organ yetmezliği değerlendirmesi skorları da sağ kalmayan grupta sağ kalan gruba göre istatistiksel olarak anlamlı derecede yüksek bulundu (p=0,005, p=0,035). Sonuç: Metil alkol intoksikasyonu nedeniyle mortal seyreden hastalarda YBÜ kabulüne kadar geçen sürede daha derin metabolik asidoz ve geri dönüşümsüz çoklu organ yetmezliği geliştiği belirlendi. Akut fizyoloji ve kronik sağlık değerlendirmesi-II ve sıralı organ yetmezliği değerlendirmesi skorlarının her ikisi de mortaliteyi öngörmede etkilir
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Aslan M, Özel Bilgi D (2024). Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. , 48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
Chicago Aslan Murat,Özel Bilgi Deniz Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. (2024): 48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
MLA Aslan Murat,Özel Bilgi Deniz Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. , 2024, ss.48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
AMA Aslan M,Özel Bilgi D Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. . 2024; 48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
Vancouver Aslan M,Özel Bilgi D Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. . 2024; 48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
IEEE Aslan M,Özel Bilgi D "Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial." , ss.48 - 54, 2024. 10.4274/BMJ.galenos.2023.2023.1-8
ISNAD Aslan, Murat - Özel Bilgi, Deniz. "Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial". (2024), 48-54. https://doi.org/10.4274/BMJ.galenos.2023.2023.1-8
APA Aslan M, Özel Bilgi D (2024). Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. Bakırköy Tıp Dergisi, 20(1), 48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
Chicago Aslan Murat,Özel Bilgi Deniz Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. Bakırköy Tıp Dergisi 20, no.1 (2024): 48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
MLA Aslan Murat,Özel Bilgi Deniz Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. Bakırköy Tıp Dergisi, vol.20, no.1, 2024, ss.48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
AMA Aslan M,Özel Bilgi D Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. Bakırköy Tıp Dergisi. 2024; 20(1): 48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
Vancouver Aslan M,Özel Bilgi D Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial. Bakırköy Tıp Dergisi. 2024; 20(1): 48 - 54. 10.4274/BMJ.galenos.2023.2023.1-8
IEEE Aslan M,Özel Bilgi D "Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial." Bakırköy Tıp Dergisi, 20, ss.48 - 54, 2024. 10.4274/BMJ.galenos.2023.2023.1-8
ISNAD Aslan, Murat - Özel Bilgi, Deniz. "Factors Predicting Mortality in Methyl Alcohol Intoxication: A Retrospective Clinical Trial". Bakırköy Tıp Dergisi 20/1 (2024), 48-54. https://doi.org/10.4274/BMJ.galenos.2023.2023.1-8