Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial

Yıl: 2024 Cilt: 52 Sayı: 2 Sayfa Aralığı: 76 - 82 Metin Dili: İngilizce DOI: 10.4274/TJAR.2024.231323 İndeks Tarihi: 11-06-2024

Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial

Öz:
Objective: Various enzymes, reactive oxygen species, inflammatory conditions, and major surgeries cause endothelial glycocalyx breakdown. Inhalation of anaesthetic agents may have protective effects on the endothelium. This study compared syndecan-1 and heparan sulfate levels to evaluate the effects of sevoflurane and desflurane on the endothelial glycocalyx. Methods: This prospective randomized, double-blind study included 46 patients undergoing laparoscopic hysterectomy. The participants were allocated into sevoflurane and desflurane groups. Subsequently, blood samples were drawn at three time points: before anaesthesia induction for a baseline value (T0), after pneumoperitoneum (T1), and after extubation (T2). Heparan sulfate and syndecan-1 levels were measured. Results: There was no statistical difference between the sevoflurane and desflurane groups in terms of heparan sulfate and syndecan-1 levels at any time point. A significant difference was found only in the desflurane group in the intragroup comparisons of the measurements of heparan sulfate levels (χ2=29.826, P < 0.001). Matched pairs of the time points in the desflurane group showed that P=0.036 (Z=-2.099) for T1-T0, P < 0.001 (Z=-3.924) for T2-T0, and P < 0.001 (Z=-4.197) for T2-T1. The change in percentage between T2 and T1 of heparan sulfate in the desflurane group was found to be statistically significant (P=0.034). Conclusion: The damage caused by surgical stress on the endothelial glycocalyx can be reduced by both desflurane and sevoflurane. The protective effect of desflurane is more prominent than that of sevoflurane.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SARAÇOĞLU T, Şimşek T, Gurbuz H, GEYİK F, Kale E, BAYDILI K, KORDI R, Kale A, Saracoglu A (2024). Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. , 76 - 82. 10.4274/TJAR.2024.231323
Chicago SARAÇOĞLU TOLGA,Şimşek Tahsin,Gurbuz Hande,GEYİK FATIH DOGU,Kale Ebru,BAYDILI Kürşad Nuri,KORDI RAGHAD Giuma M,Kale Ahmet,Saracoglu Ayten Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. (2024): 76 - 82. 10.4274/TJAR.2024.231323
MLA SARAÇOĞLU TOLGA,Şimşek Tahsin,Gurbuz Hande,GEYİK FATIH DOGU,Kale Ebru,BAYDILI Kürşad Nuri,KORDI RAGHAD Giuma M,Kale Ahmet,Saracoglu Ayten Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. , 2024, ss.76 - 82. 10.4274/TJAR.2024.231323
AMA SARAÇOĞLU T,Şimşek T,Gurbuz H,GEYİK F,Kale E,BAYDILI K,KORDI R,Kale A,Saracoglu A Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. . 2024; 76 - 82. 10.4274/TJAR.2024.231323
Vancouver SARAÇOĞLU T,Şimşek T,Gurbuz H,GEYİK F,Kale E,BAYDILI K,KORDI R,Kale A,Saracoglu A Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. . 2024; 76 - 82. 10.4274/TJAR.2024.231323
IEEE SARAÇOĞLU T,Şimşek T,Gurbuz H,GEYİK F,Kale E,BAYDILI K,KORDI R,Kale A,Saracoglu A "Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial." , ss.76 - 82, 2024. 10.4274/TJAR.2024.231323
ISNAD SARAÇOĞLU, TOLGA vd. "Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial". (2024), 76-82. https://doi.org/10.4274/TJAR.2024.231323
APA SARAÇOĞLU T, Şimşek T, Gurbuz H, GEYİK F, Kale E, BAYDILI K, KORDI R, Kale A, Saracoglu A (2024). Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. Turkish Journal of Anaesthesiology and Reanimation, 52(2), 76 - 82. 10.4274/TJAR.2024.231323
Chicago SARAÇOĞLU TOLGA,Şimşek Tahsin,Gurbuz Hande,GEYİK FATIH DOGU,Kale Ebru,BAYDILI Kürşad Nuri,KORDI RAGHAD Giuma M,Kale Ahmet,Saracoglu Ayten Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. Turkish Journal of Anaesthesiology and Reanimation 52, no.2 (2024): 76 - 82. 10.4274/TJAR.2024.231323
MLA SARAÇOĞLU TOLGA,Şimşek Tahsin,Gurbuz Hande,GEYİK FATIH DOGU,Kale Ebru,BAYDILI Kürşad Nuri,KORDI RAGHAD Giuma M,Kale Ahmet,Saracoglu Ayten Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. Turkish Journal of Anaesthesiology and Reanimation, vol.52, no.2, 2024, ss.76 - 82. 10.4274/TJAR.2024.231323
AMA SARAÇOĞLU T,Şimşek T,Gurbuz H,GEYİK F,Kale E,BAYDILI K,KORDI R,Kale A,Saracoglu A Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. Turkish Journal of Anaesthesiology and Reanimation. 2024; 52(2): 76 - 82. 10.4274/TJAR.2024.231323
Vancouver SARAÇOĞLU T,Şimşek T,Gurbuz H,GEYİK F,Kale E,BAYDILI K,KORDI R,Kale A,Saracoglu A Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial. Turkish Journal of Anaesthesiology and Reanimation. 2024; 52(2): 76 - 82. 10.4274/TJAR.2024.231323
IEEE SARAÇOĞLU T,Şimşek T,Gurbuz H,GEYİK F,Kale E,BAYDILI K,KORDI R,Kale A,Saracoglu A "Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial." Turkish Journal of Anaesthesiology and Reanimation, 52, ss.76 - 82, 2024. 10.4274/TJAR.2024.231323
ISNAD SARAÇOĞLU, TOLGA vd. "Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double-Blind Trial". Turkish Journal of Anaesthesiology and Reanimation 52/2 (2024), 76-82. https://doi.org/10.4274/TJAR.2024.231323