Yıl: 2024 Cilt: 48 Sayı: 1 Sayfa Aralığı: 8 - 14 Metin Dili: İngilizce DOI: 10.4274/tpd.galenos.2024.74046 İndeks Tarihi: 11-06-2024

Congenital Toxoplasmosis and Long-term Outcomes

Öz:
Objective: Congenital toxoplasmosis (CT) can have severe early and late sequelae in children. In this study, we aimed to evaluate the demographic, clinical, treatment characteristics of patients diagnosed with congenital Toxoplasma infection and to highlight the long-term complications of the patients. Methods: Patients with CT were included in this study who were followed between 2010 and 2022 in Cukurova University Medical Faculty Hospital. Demographic, clinical and treatment characteristics were searched retrospectively. In the diagnosis of maternal and CT, Toxoplasma IgM, IgG, IgG avidity, T. gondii polymerase chain reaction tests were used along with clinical and symptoms. Results: Eighteen children (two twins) with CT and their mothers (n=16) were included in the study. Median age was 1 month. Ten (55.5%) of the children were male. CT diagnosis was made during pregnancy in 7 mothers (resulting in 8 babies) and postnatally in 9 mothers (resulting in 10 babies). The mothers of 5 (31.1%) babies with CT received spiramycin treatment during pregnancy. Three (60%) of 5 pregnant women who received spiramycin were diagnosed in the first trimester, 4 (80%) of the babies did not have any sequale and only 1 (20%) had microphthalmia. Ocular involvement was the most common presentation of the disease occured in 10 patients (55.5%), hydrocephalus and intracranial calcification developed in five patients (27.7%). Hearing loss developed in 2 (11.1%) patients. During the follow-up period, seizures developed in 3 patients (16.6%), microcephaly in 2 patients (11.1%), and neurodevolopmental retardation in 7 patients (38.8%), two of the patients had severe mental retardation. One (5.5%) patient with hydrocephalus died at 36 months of age due to complications after ventriculoperitoneal shunt application. Conclusion: In our study, we observed severe sequelae in vision, hearing, and neurodevelopmental aspects in children diagnosed with CT at birth and during follow-ups. Early diagnosis and treatment of infants, along with the detection of Toxoplasma infection during pregnancy, are essential in preventing severe sequelae that may arise due to CT.
Anahtar Kelime: Congenital toxoplasmosis children chorioretinitis

Konjenital Toksoplazmozis ve Uzun Dönem Sonuçları

Öz:
Amaç: Konjenital toksoplazma enfeksiyonu çocuklarda erken ve geç dönemde ağır sekellere neden olur. Biz bu çalışmada konjenital toksoplazma tanısı alan hastaların demografik, klinik, tanı, tedavi özelliklerini ve hastaların uzun dönemde gelişen komplikasyonlarını değerlendirmeyi amaçladık. Yöntemler: Bu çalışmada Çukurova Üniversitesi Tıp Fakültesi Hastanesi’nde 2010-2022 yılları arasında konjenital Toksoplazma enfeksiyonu saptanan bebeklerin demografik, klinik, tanı, tedavi özellikleri ve prognozları retrospektif olarak değerlendirilmiştir. Maternal ve konjenital Toxoplasma enfeksiyonu tanısında, klinik belirti ve bulgularla birlikte Toxoplasma IgM, IgG ve IgG avidite, T. gondii polimeraz zincir reaksiyon testleri kullanıldı. Bulgular: Bu çalışmaya medyan yaşı 1 ay olan 10’u (%55,5) erkek, ikisi ikiz olan 18 konjenital Toxoplasma tanısı alan bebek ve bu bebeklerin anneleri (n=16) dahil edildi. Konjenital Toxoplasma tanısı, 7 annede gebelik sırasında (bunların 8 bebeği) ve 9 annede doğum sonrasında (bunların 10 bebeği) konuldu. Konjenital toksoplazmalı bebeklerin 5’inin (%31,1) annesinin gebeliğinde spiramisin tedavisi aldığı belirlendi. Spiramisin alan 5 gebeden 3’ünün (%60) ilk trimestarda tanı almasına rağmen bebeklerin 4’ünde organ tutulumu olmayıp yalnızca 1’inde mikroftalmi mevcut idi. Konjenital Toxoplasma tanısı alan bebeklerin tanı anında en sık 10 (%55,5) hastada göz tutulumu olduğu ve hastaların 5’inde (%27,7) hidrosefali ve intrakraniyal kalsifikasyon olduğu saptandı. İki (%11,1) hastada işitme kaybı geliştiği belirlendi. İzlemde 3 hastada (%16,6) nöbet, 2 hastada (%11,1) mikrosefali ve ikisi ağır mental retardasyon olan 7 hastada (%38,8) nörogelişimsel gerilik olduğu saptandı. Bir (%5,5) hastanın 36 aylıkken hidrosefali ve ventriküloperitoneal şant uygulanması sonrası gelişen komplikasyonlar nedeniyle yaşamını yitirdiği saptandı. Sonuç: Çalışmamızda, doğumda ve takiplerde konjenital Toxoplasma tanısı konulan çocuklarda görme, işitme ve nörogelişimsel alanlarda ciddi sonuçlar gözlemledik. Bebeklerin erken tanı ve tedavisi ile birlikte gebelikte Toxoplasma enfeksiyonunun tespiti, konjenital Toxoplasma kaynaklı ciddi sonuçların önlenmesinde esastır.
Anahtar Kelime: Konjenital toksoplazmozis çocuk koryoretinit

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Özgür Gündeşlioğlu Ö, Haytoglu Z, Esen E, Alabaz D, çay ü, ÖZLÜ F, kibar f, ÇETINER S (2024). Congenital Toxoplasmosis and Long-term Outcomes. , 8 - 14. 10.4274/tpd.galenos.2024.74046
Chicago Özgür Gündeşlioğlu Özlem,Haytoglu Zeliha,Esen Ebru,Alabaz Derya,çay ümmühan,ÖZLÜ FERDA,kibar filiz,ÇETINER SALIH Congenital Toxoplasmosis and Long-term Outcomes. (2024): 8 - 14. 10.4274/tpd.galenos.2024.74046
MLA Özgür Gündeşlioğlu Özlem,Haytoglu Zeliha,Esen Ebru,Alabaz Derya,çay ümmühan,ÖZLÜ FERDA,kibar filiz,ÇETINER SALIH Congenital Toxoplasmosis and Long-term Outcomes. , 2024, ss.8 - 14. 10.4274/tpd.galenos.2024.74046
AMA Özgür Gündeşlioğlu Ö,Haytoglu Z,Esen E,Alabaz D,çay ü,ÖZLÜ F,kibar f,ÇETINER S Congenital Toxoplasmosis and Long-term Outcomes. . 2024; 8 - 14. 10.4274/tpd.galenos.2024.74046
Vancouver Özgür Gündeşlioğlu Ö,Haytoglu Z,Esen E,Alabaz D,çay ü,ÖZLÜ F,kibar f,ÇETINER S Congenital Toxoplasmosis and Long-term Outcomes. . 2024; 8 - 14. 10.4274/tpd.galenos.2024.74046
IEEE Özgür Gündeşlioğlu Ö,Haytoglu Z,Esen E,Alabaz D,çay ü,ÖZLÜ F,kibar f,ÇETINER S "Congenital Toxoplasmosis and Long-term Outcomes." , ss.8 - 14, 2024. 10.4274/tpd.galenos.2024.74046
ISNAD Özgür Gündeşlioğlu, Özlem vd. "Congenital Toxoplasmosis and Long-term Outcomes". (2024), 8-14. https://doi.org/10.4274/tpd.galenos.2024.74046
APA Özgür Gündeşlioğlu Ö, Haytoglu Z, Esen E, Alabaz D, çay ü, ÖZLÜ F, kibar f, ÇETINER S (2024). Congenital Toxoplasmosis and Long-term Outcomes. Türkiye Parazitoloji Dergisi, 48(1), 8 - 14. 10.4274/tpd.galenos.2024.74046
Chicago Özgür Gündeşlioğlu Özlem,Haytoglu Zeliha,Esen Ebru,Alabaz Derya,çay ümmühan,ÖZLÜ FERDA,kibar filiz,ÇETINER SALIH Congenital Toxoplasmosis and Long-term Outcomes. Türkiye Parazitoloji Dergisi 48, no.1 (2024): 8 - 14. 10.4274/tpd.galenos.2024.74046
MLA Özgür Gündeşlioğlu Özlem,Haytoglu Zeliha,Esen Ebru,Alabaz Derya,çay ümmühan,ÖZLÜ FERDA,kibar filiz,ÇETINER SALIH Congenital Toxoplasmosis and Long-term Outcomes. Türkiye Parazitoloji Dergisi, vol.48, no.1, 2024, ss.8 - 14. 10.4274/tpd.galenos.2024.74046
AMA Özgür Gündeşlioğlu Ö,Haytoglu Z,Esen E,Alabaz D,çay ü,ÖZLÜ F,kibar f,ÇETINER S Congenital Toxoplasmosis and Long-term Outcomes. Türkiye Parazitoloji Dergisi. 2024; 48(1): 8 - 14. 10.4274/tpd.galenos.2024.74046
Vancouver Özgür Gündeşlioğlu Ö,Haytoglu Z,Esen E,Alabaz D,çay ü,ÖZLÜ F,kibar f,ÇETINER S Congenital Toxoplasmosis and Long-term Outcomes. Türkiye Parazitoloji Dergisi. 2024; 48(1): 8 - 14. 10.4274/tpd.galenos.2024.74046
IEEE Özgür Gündeşlioğlu Ö,Haytoglu Z,Esen E,Alabaz D,çay ü,ÖZLÜ F,kibar f,ÇETINER S "Congenital Toxoplasmosis and Long-term Outcomes." Türkiye Parazitoloji Dergisi, 48, ss.8 - 14, 2024. 10.4274/tpd.galenos.2024.74046
ISNAD Özgür Gündeşlioğlu, Özlem vd. "Congenital Toxoplasmosis and Long-term Outcomes". Türkiye Parazitoloji Dergisi 48/1 (2024), 8-14. https://doi.org/10.4274/tpd.galenos.2024.74046