Yıl: 2024 Cilt: 16 Sayı: 1 Sayfa Aralığı: 21 - 30 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2023.2022-12-7 İndeks Tarihi: 11-06-2024

Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study

Öz:
Objective: Vitamin D is a potent immune modulator and is associated with autoimmune diseases, including type 1 diabetes (T1D). The vitamin D levels and its receptor gene polymorphisms together in T1D are not yet investigated in the South Indian population. The present study focused on exploring the significance of vitamin D levels and vitamin D receptor (VDR) gene polymorphisms with the risk of developing T1D in the South Indian population. Methods: Patients with T1D and unaffected first-degree relatives (FDRs) were included in this study. Genotyping of VDR polymorphisms at four different loci (FokI- F/f, BsmI- B/b, TaqI- T/t, and ApaI- A/a) was assessed through the amplification refractive mutation system- polymerase chain reaction method. Serum vitamin D levels were measured in 98 T1D patients and 75 age- and sex-matched siblings. Results: A total of 120 patients with T1D and 214 FDRs were included. Vitamin D deficiency (VDD) was observed in a higher proportion of T1D patients than in controls (52% vs. 32%; p<0.03). The frequency of the FokI-FF genotype was significantly higher [odds ratio (OR)=1.66; p<0.03] in T1D patients conferring a susceptible association with the disease. Nevertheless, the increased frequency of heterozygous Ff genotype (OR=0.57; p<0.02) among controls may confer a protective association with T1D. Furthermore, the transmission disequilibrium test revealed over-transmission of ApaI-A (T: U=15/5; p<0.006) and BsmI-B alleles (T: U=17/5; p<0.01) and under-transmission of BsmI-b/ApaI-a/TaqI-T haplotype (T: U=5.4/14.4; p=0.04) from parents to T1D patients. Conclusion: The present study concludes that VDD is the major contributing risk factor to T1D development in the South Indian population. Furthermore, the FokI-FF genotype, BsmI-B, and ApaI-A alleles were positively associated with T1D. In contrast, the FokI-Ff genotype and BsmI-b/ApaI-a/TaqI-T haplotype were negatively associated with T1D.
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APA Ramasamy T, Ayyappan C, ASIRVATHAM A, MARIAKUTTIKAN J (2024). Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. , 21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
Chicago Ramasamy Thirunavukkarasu,Ayyappan Chitra,ASIRVATHAM ARTHUR JOSEPH,MARIAKUTTIKAN JAYALAKSHMI Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. (2024): 21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
MLA Ramasamy Thirunavukkarasu,Ayyappan Chitra,ASIRVATHAM ARTHUR JOSEPH,MARIAKUTTIKAN JAYALAKSHMI Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. , 2024, ss.21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
AMA Ramasamy T,Ayyappan C,ASIRVATHAM A,MARIAKUTTIKAN J Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. . 2024; 21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
Vancouver Ramasamy T,Ayyappan C,ASIRVATHAM A,MARIAKUTTIKAN J Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. . 2024; 21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
IEEE Ramasamy T,Ayyappan C,ASIRVATHAM A,MARIAKUTTIKAN J "Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study." , ss.21 - 30, 2024. 10.4274/jcrpe.galenos.2023.2022-12-7
ISNAD Ramasamy, Thirunavukkarasu vd. "Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study". (2024), 21-30. https://doi.org/10.4274/jcrpe.galenos.2023.2022-12-7
APA Ramasamy T, Ayyappan C, ASIRVATHAM A, MARIAKUTTIKAN J (2024). Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. Journal of Clinical Research in Pediatric Endocrinology, 16(1), 21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
Chicago Ramasamy Thirunavukkarasu,Ayyappan Chitra,ASIRVATHAM ARTHUR JOSEPH,MARIAKUTTIKAN JAYALAKSHMI Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. Journal of Clinical Research in Pediatric Endocrinology 16, no.1 (2024): 21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
MLA Ramasamy Thirunavukkarasu,Ayyappan Chitra,ASIRVATHAM ARTHUR JOSEPH,MARIAKUTTIKAN JAYALAKSHMI Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. Journal of Clinical Research in Pediatric Endocrinology, vol.16, no.1, 2024, ss.21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
AMA Ramasamy T,Ayyappan C,ASIRVATHAM A,MARIAKUTTIKAN J Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. Journal of Clinical Research in Pediatric Endocrinology. 2024; 16(1): 21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
Vancouver Ramasamy T,Ayyappan C,ASIRVATHAM A,MARIAKUTTIKAN J Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study. Journal of Clinical Research in Pediatric Endocrinology. 2024; 16(1): 21 - 30. 10.4274/jcrpe.galenos.2023.2022-12-7
IEEE Ramasamy T,Ayyappan C,ASIRVATHAM A,MARIAKUTTIKAN J "Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study." Journal of Clinical Research in Pediatric Endocrinology, 16, ss.21 - 30, 2024. 10.4274/jcrpe.galenos.2023.2022-12-7
ISNAD Ramasamy, Thirunavukkarasu vd. "Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study". Journal of Clinical Research in Pediatric Endocrinology 16/1 (2024), 21-30. https://doi.org/10.4274/jcrpe.galenos.2023.2022-12-7