Yıl: 2024 Cilt: 16 Sayı: 1 Sayfa Aralığı: 15 - 24 Metin Dili: İngilizce DOI: 10.4274/raed.galenos.2024.52714 İndeks Tarihi: 11-06-2024

Infection frequency may not increase in Familial Mediterranean fever

Öz:
Objective: To the best of our knowledge, there is no study evaluating the infectious features of Familial Mediterranean fever (FMF) in the literature. Here, we tested two hypotheses: infection is more common in FMF and FMF severity and infection may be linked. Methods: We included three groups: FMF (363 patients), spondyloarthropathy (SpA-patients) (112 patients) and control (121 patients). We screened participants for infection characteristics in the last year with a pre-approved and validated questionnaire. Firstly, we compared infection rates, frequency of infection types, and infection severity within groups. We then evaluated the factors associated with infection in FMF. Results: We found that infection rates were similar in FMF, SpA-patients and controls. However, admission to the infection outpatient clinic was more common in FMF (p=0.001) and the duration of workforce loss due to infection was longer in FMF than controls (p=0.002). Furthermore, FMF-patients with infection had higher disease severity (p=0.004), high acute phase reactants between attacks (p=0.006) and more site involvement during attacks (p<0.001). In multivariate analyses, the latter was found to be significant (p=0.003). Conclusion: We discovered no increase in the infection rate of FMF patients. Patients with infections, on the other hand, may have more severe FMF.
Anahtar Kelime: Auto-inflammatory diseases disease activity Familial Mediterranean fever infection

Ailevi Akdeniz ateşinde enfeksiyon sıklığı artmayabilir

Öz:
Amaç: Literatürde Ailevi Akdeniz ateşi (AAA) enfeksiyon özelliklerini değerlendiren bir çalışma bulunmamaktadır. Bu çalışmada, iki hipotezi test ettik: enfeksiyon AAA’da daha yaygın olabilir ve AAA şiddeti ile enfeksiyon arasında bir ilişki olabilir. Yöntem: Çalışmaya üç ayrı grup dahil ettik: AAA (363 hasta), spondiloartropati (SpA) (112 hasta) ve kontrol (121 hasta). Katılımcıları son bir yıl içindeki enfeksiyon özellikleri açısından önceden onaylanmış ve geçerli bir anketle taradık. İlk olarak, gruplar içinde enfeksiyon oranlarını, enfeksiyon türlerinin sıklığını ve enfeksiyonun şiddetini karşılaştırdık. Daha sonra AAA’da enfeksiyonla ilişkilendirilen faktörleri değerlendirdik. Bulgular: AAA, SpA-hastaları ve kontroller arasında enfeksiyon oranlarının benzer olduğunu bulduk. Ancak, enfeksiyon polikliniğine başvuru AAA’da daha yaygındı (p=0,001) ve enfeksiyon nedeniyle iş gücü kaybının süresi AAA’da kontrollere göre daha uzundu (p=0,002). Ayrıca, enfeksiyonlu AAA hastalarının daha yüksek hastalık şiddeti (p=0,004), ataklar arası yüksek akut faz reaktanları (p=0,006) ve ataklar sırasında daha fazla bölge tutulumu (p<0,001) vardı. Çoklu değişken analizlerinde, sonuncusunun önemli olduğu bulundu (p=0,003). Sonuç: Çalışmamızda AAA hastalarının enfeksiyon oranında artış gözlenmemiştir. Bununla birlikte, enfeksiyonlu hastaların daha şiddetli AAA’ya sahip olabileceği görülmüştür.
Anahtar Kelime: Oto-enflamatuvar hastalıklar hastalık aktivitesi Ailevi Akdeniz ateşi enfeksiyon

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Şen N, mercan r, volkan o, Bayar E, Yilmaz-Oner S, Tezcan M (2024). Infection frequency may not increase in Familial Mediterranean fever. , 15 - 24. 10.4274/raed.galenos.2024.52714
Chicago Şen Nesrin,mercan ridvan,volkan omur,Bayar Esra,Yilmaz-Oner Sibel,Tezcan Mehmet Engin Infection frequency may not increase in Familial Mediterranean fever. (2024): 15 - 24. 10.4274/raed.galenos.2024.52714
MLA Şen Nesrin,mercan ridvan,volkan omur,Bayar Esra,Yilmaz-Oner Sibel,Tezcan Mehmet Engin Infection frequency may not increase in Familial Mediterranean fever. , 2024, ss.15 - 24. 10.4274/raed.galenos.2024.52714
AMA Şen N,mercan r,volkan o,Bayar E,Yilmaz-Oner S,Tezcan M Infection frequency may not increase in Familial Mediterranean fever. . 2024; 15 - 24. 10.4274/raed.galenos.2024.52714
Vancouver Şen N,mercan r,volkan o,Bayar E,Yilmaz-Oner S,Tezcan M Infection frequency may not increase in Familial Mediterranean fever. . 2024; 15 - 24. 10.4274/raed.galenos.2024.52714
IEEE Şen N,mercan r,volkan o,Bayar E,Yilmaz-Oner S,Tezcan M "Infection frequency may not increase in Familial Mediterranean fever." , ss.15 - 24, 2024. 10.4274/raed.galenos.2024.52714
ISNAD Şen, Nesrin vd. "Infection frequency may not increase in Familial Mediterranean fever". (2024), 15-24. https://doi.org/10.4274/raed.galenos.2024.52714
APA Şen N, mercan r, volkan o, Bayar E, Yilmaz-Oner S, Tezcan M (2024). Infection frequency may not increase in Familial Mediterranean fever. Ulusal Romatoloji Dergisi, 16(1), 15 - 24. 10.4274/raed.galenos.2024.52714
Chicago Şen Nesrin,mercan ridvan,volkan omur,Bayar Esra,Yilmaz-Oner Sibel,Tezcan Mehmet Engin Infection frequency may not increase in Familial Mediterranean fever. Ulusal Romatoloji Dergisi 16, no.1 (2024): 15 - 24. 10.4274/raed.galenos.2024.52714
MLA Şen Nesrin,mercan ridvan,volkan omur,Bayar Esra,Yilmaz-Oner Sibel,Tezcan Mehmet Engin Infection frequency may not increase in Familial Mediterranean fever. Ulusal Romatoloji Dergisi, vol.16, no.1, 2024, ss.15 - 24. 10.4274/raed.galenos.2024.52714
AMA Şen N,mercan r,volkan o,Bayar E,Yilmaz-Oner S,Tezcan M Infection frequency may not increase in Familial Mediterranean fever. Ulusal Romatoloji Dergisi. 2024; 16(1): 15 - 24. 10.4274/raed.galenos.2024.52714
Vancouver Şen N,mercan r,volkan o,Bayar E,Yilmaz-Oner S,Tezcan M Infection frequency may not increase in Familial Mediterranean fever. Ulusal Romatoloji Dergisi. 2024; 16(1): 15 - 24. 10.4274/raed.galenos.2024.52714
IEEE Şen N,mercan r,volkan o,Bayar E,Yilmaz-Oner S,Tezcan M "Infection frequency may not increase in Familial Mediterranean fever." Ulusal Romatoloji Dergisi, 16, ss.15 - 24, 2024. 10.4274/raed.galenos.2024.52714
ISNAD Şen, Nesrin vd. "Infection frequency may not increase in Familial Mediterranean fever". Ulusal Romatoloji Dergisi 16/1 (2024), 15-24. https://doi.org/10.4274/raed.galenos.2024.52714