Yıl: 2024 Cilt: 16 Sayı: 1 Sayfa Aralığı: 32 - 37 Metin Dili: İngilizce DOI: 10.4274/raed.galenos.2023.13007 İndeks Tarihi: 11-06-2024

The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients

Öz:
Objective: Autoimmune diseases (ADs) are observed more frequently in patients with breast cancer (BC) compared to healthy population. However, the frequency of ADs in their relatives has not been studied. In the present study, we aimed to compare the frequency of ADs among the first-degree and other relatives of patients with BC with healthy controls. Methods: We included 100 women aged 18 years and older who were followed up with the diagnosis of BC in our oncology clinic, and randomly selected female employees aged 18 and over in our hospital as the control group. The frequencies of ADs among relatives of the two groups were investigated using a detailed questionnaire. Results: Frequency of having at least one relative with AD was 76% in the BC group and 36% in the control group (p<0.001). The frequency of ADs in the relatives of the BC group was 5.5 times higher than in the relatives of the control group. In detailed analyzes, when the degree of kinship was considered, it was found that the risk increased to 11.5 times in the first-degree relatives of BC patients; however, no increased risk was found among more distant relatives. Conclusion: In our study, we found more ADs among the first-degree relatives of patients with BC compared to the control group. This result suggests that common genetic factors may be playing roles in the pathogenesis of BC and ADs.
Anahtar Kelime: Breast cancer autoimmune diseases genetic predispositio

Meme kanserli hastaların birinci derece ve diğer yakınlarındaki otoimmün hastalık sıklığı

Öz:
Amaç: Otoimmün hastalıklar (OİH), meme kanseri (MK) hastalarında sağlıklı popülasyona göre daha sık görülmektedir. Ancak hasta yakınlarında OİH sıklığı çalışılmamıştır. Bu çalışmada, MK’li hastaların birinci derece ve diğer akrabalarında OİH sıklığını sağlıklı kontrollerle karşılaştırmayı amaçladık. Yöntem: Onkoloji kliniğimizde MK tanısı ile izlenen 18 yaş ve üstü ardışık 100 kadını ve kontrol grubu olarak hastanemizin rastgele seçilmiş 18 yaş ve üzeri kadın çalışanlarını dahil ettik. İki grubun akrabaları arasındaki OİH sıklıkları ayrıntılı bir anket kullanılarak araştırıldı. Bulgular: Çalışma gruplarının akrabaları arasında en az bir OİH varlığı, MK grubunun akrabalarında %76 iken, kontrol grubunun akrabalarında %36 idi (p<0,001). MK grubu akrabalarındaki OİH sıklığı, kontrol grubu akrabalarına kıyasla 5,5 kat daha fazlaydı. Akrabalık derecesi dikkate alınarak yapılan detaylı analizlerde, MK hastalarının birinci derece akrabalarında riskin 11,5 kat arttığını; ancak, daha uzak akrabalar arasında risk artışı olmadığı tespit edildi. Sonuç: Çalışmamızda, MK hastalarının birinci akrabaları arasında, kontrol grubuna kıyasla daha fazla OİH saptadık. Bu sonuç, MK ile OİH’nin patogenezinde ortak genetik faktörlerin rol oynayabileceğini düşündürmektedir.
Anahtar Kelime: Meme kanseri otoimmün hastalıklar genetik yatkınlık

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Atay A, Goker B, öztürk m, TUFAN A, HAZNEDAROGLU S, Babaoglu H, Ozet A, Üner A, GÜNEL N, tahtaci g (2024). The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. , 32 - 37. 10.4274/raed.galenos.2023.13007
Chicago Atay Ali,Goker Berna,öztürk mehmet akif,TUFAN ABDURRAHMAN,HAZNEDAROGLU SEMINUR,Babaoglu Hakan,Ozet Ahmet,Üner Aytuğ,GÜNEL NAZAN,tahtaci gozde The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. (2024): 32 - 37. 10.4274/raed.galenos.2023.13007
MLA Atay Ali,Goker Berna,öztürk mehmet akif,TUFAN ABDURRAHMAN,HAZNEDAROGLU SEMINUR,Babaoglu Hakan,Ozet Ahmet,Üner Aytuğ,GÜNEL NAZAN,tahtaci gozde The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. , 2024, ss.32 - 37. 10.4274/raed.galenos.2023.13007
AMA Atay A,Goker B,öztürk m,TUFAN A,HAZNEDAROGLU S,Babaoglu H,Ozet A,Üner A,GÜNEL N,tahtaci g The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. . 2024; 32 - 37. 10.4274/raed.galenos.2023.13007
Vancouver Atay A,Goker B,öztürk m,TUFAN A,HAZNEDAROGLU S,Babaoglu H,Ozet A,Üner A,GÜNEL N,tahtaci g The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. . 2024; 32 - 37. 10.4274/raed.galenos.2023.13007
IEEE Atay A,Goker B,öztürk m,TUFAN A,HAZNEDAROGLU S,Babaoglu H,Ozet A,Üner A,GÜNEL N,tahtaci g "The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients." , ss.32 - 37, 2024. 10.4274/raed.galenos.2023.13007
ISNAD Atay, Ali vd. "The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients". (2024), 32-37. https://doi.org/10.4274/raed.galenos.2023.13007
APA Atay A, Goker B, öztürk m, TUFAN A, HAZNEDAROGLU S, Babaoglu H, Ozet A, Üner A, GÜNEL N, tahtaci g (2024). The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. Ulusal Romatoloji Dergisi, 16(1), 32 - 37. 10.4274/raed.galenos.2023.13007
Chicago Atay Ali,Goker Berna,öztürk mehmet akif,TUFAN ABDURRAHMAN,HAZNEDAROGLU SEMINUR,Babaoglu Hakan,Ozet Ahmet,Üner Aytuğ,GÜNEL NAZAN,tahtaci gozde The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. Ulusal Romatoloji Dergisi 16, no.1 (2024): 32 - 37. 10.4274/raed.galenos.2023.13007
MLA Atay Ali,Goker Berna,öztürk mehmet akif,TUFAN ABDURRAHMAN,HAZNEDAROGLU SEMINUR,Babaoglu Hakan,Ozet Ahmet,Üner Aytuğ,GÜNEL NAZAN,tahtaci gozde The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. Ulusal Romatoloji Dergisi, vol.16, no.1, 2024, ss.32 - 37. 10.4274/raed.galenos.2023.13007
AMA Atay A,Goker B,öztürk m,TUFAN A,HAZNEDAROGLU S,Babaoglu H,Ozet A,Üner A,GÜNEL N,tahtaci g The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. Ulusal Romatoloji Dergisi. 2024; 16(1): 32 - 37. 10.4274/raed.galenos.2023.13007
Vancouver Atay A,Goker B,öztürk m,TUFAN A,HAZNEDAROGLU S,Babaoglu H,Ozet A,Üner A,GÜNEL N,tahtaci g The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients. Ulusal Romatoloji Dergisi. 2024; 16(1): 32 - 37. 10.4274/raed.galenos.2023.13007
IEEE Atay A,Goker B,öztürk m,TUFAN A,HAZNEDAROGLU S,Babaoglu H,Ozet A,Üner A,GÜNEL N,tahtaci g "The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients." Ulusal Romatoloji Dergisi, 16, ss.32 - 37, 2024. 10.4274/raed.galenos.2023.13007
ISNAD Atay, Ali vd. "The frequency of autoimmune disease in the first degree and other relatives of the breast cancer patients". Ulusal Romatoloji Dergisi 16/1 (2024), 32-37. https://doi.org/10.4274/raed.galenos.2023.13007