Yıl: 2024 Cilt: 16 Sayı: 1 Sayfa Aralığı: 69 - 75 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2023.2023-5-21 İndeks Tarihi: 11-06-2024

Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age

Öz:
Objective: Children born small for gestational age (SGA) are at a greater risk of developing insulin resistance, type 2 diabetes, and cardiovascular disease in adulthood. Gastrointestinal peptides, some secreted by intestinal L cells, regulate glucose and lipid metabolism and act on the hypothalamus to regulate energy homeostasis. The aim of this study was to explore whether gastrointestinal peptides are involved in metabolic disorders in SGA, which remains unclear. Methods: The secretion of glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) were investigated in prepubertal children born SGA, the differences between catch-up growth and persistent short stature were compared, and correlation with glucose and lipid metabolism was analyzed. GLP-1, PYY, insulin-like growth factor 1, glucose, insulin, and lipid concentrations were analyzed in prepubertal children aged 4-10 years, stratified into three groups: short-SGA (SGA-s), catch-up growth SGA, and normal growth appropriate for gestational age (AGA). Results: Fasting GLP-1 and PYY concentrations were significantly lower in the SGA group than in the AGA group (p<0.05), and the GLP-1 level in infants born SGA with catch-up growth was lower than that in the SGA-s group (p<0.05). In the SGA population, GLP-1 showed a weak negative correlation with catch-up growth (r=-0.326) and positive correlation with fasting insulin (r=0.331). Conclusion: Lower GLP-1 concentrations may be associated with abnormal glucose metabolism in prepubertal children born SGA with catch-up growth. This is indirect evidence that impaired intestinal L cell function may be involved in the development of metabolic complications in SGA children.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA WANG L, SU Z, LI Y, CAO B, SU C, Gong C (2024). Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. , 69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
Chicago WANG Li,SU Zhe,LI Yu Chuan,CAO Bing Yan,SU Chang,Gong Chun Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. (2024): 69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
MLA WANG Li,SU Zhe,LI Yu Chuan,CAO Bing Yan,SU Chang,Gong Chun Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. , 2024, ss.69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
AMA WANG L,SU Z,LI Y,CAO B,SU C,Gong C Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. . 2024; 69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
Vancouver WANG L,SU Z,LI Y,CAO B,SU C,Gong C Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. . 2024; 69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
IEEE WANG L,SU Z,LI Y,CAO B,SU C,Gong C "Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age." , ss.69 - 75, 2024. 10.4274/jcrpe.galenos.2023.2023-5-21
ISNAD WANG, Li vd. "Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age". (2024), 69-75. https://doi.org/10.4274/jcrpe.galenos.2023.2023-5-21
APA WANG L, SU Z, LI Y, CAO B, SU C, Gong C (2024). Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. Journal of Clinical Research in Pediatric Endocrinology, 16(1), 69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
Chicago WANG Li,SU Zhe,LI Yu Chuan,CAO Bing Yan,SU Chang,Gong Chun Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. Journal of Clinical Research in Pediatric Endocrinology 16, no.1 (2024): 69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
MLA WANG Li,SU Zhe,LI Yu Chuan,CAO Bing Yan,SU Chang,Gong Chun Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. Journal of Clinical Research in Pediatric Endocrinology, vol.16, no.1, 2024, ss.69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
AMA WANG L,SU Z,LI Y,CAO B,SU C,Gong C Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. Journal of Clinical Research in Pediatric Endocrinology. 2024; 16(1): 69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
Vancouver WANG L,SU Z,LI Y,CAO B,SU C,Gong C Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age. Journal of Clinical Research in Pediatric Endocrinology. 2024; 16(1): 69 - 75. 10.4274/jcrpe.galenos.2023.2023-5-21
IEEE WANG L,SU Z,LI Y,CAO B,SU C,Gong C "Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age." Journal of Clinical Research in Pediatric Endocrinology, 16, ss.69 - 75, 2024. 10.4274/jcrpe.galenos.2023.2023-5-21
ISNAD WANG, Li vd. "Relationship of Glucagon-like Peptide 1 and Peptide YY with Catch-up Growth in Children Born Small for Gestational Age". Journal of Clinical Research in Pediatric Endocrinology 16/1 (2024), 69-75. https://doi.org/10.4274/jcrpe.galenos.2023.2023-5-21