Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study

GENÇ, Ahmet; UYAREL, Hüseyin; DUYGU, Egemen; ÖKMEN, Arda Şanlı; BUTURAK, ALİ; ULUS, Özden Sıla

Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study

Ali BUTURAK, (Ardahan Askeri Hastanesi, Kardiyoloji Kliniği, Ardahan, Türkiye)

Ahmet GENÇ, (Ardahan Devlet Hastanesi, Kardiyoloji Kliniği, Ardahan, Türkiye)

Özden Sıla ULUS, (Ardahan Devlet Hastanesi, Radyoloji Kliniği, Ardahan, Türkiye)

Egemen DUYGU, (Sarıkamış Askeri Hastanesi, Kardiyoloji Kliniği, Kars, Türkiye)

Arda Şanlı ÖKMEN, (İstanbul Memorial Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Hüseyin UYAREL (Balıkesir Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Balıkesir, Türkiye)

Anadolu Kardiyoloji Dergisi

1 2

Yıl: 2011 Cilt: 11 Sayı: 6 Sayfa Aralığı: 492 - 497 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study

Öz:

Amaç: Hayvansal biyokütle yakıtı (tezek) dumanı inhalasyon ürünlerine kronik olarak maruz kalan bireylerde endoteliyal fonksiyonların değerlendirilmesi. Yöntemler: Doğumlarından itibaren tezek dumanı inhalasyon ürünleri maruziyeti olan 47 sağlıklı birey (ortalama yaş 31.6±6.8 yıl, 21 erkek) enine kesitli gözlemsel çalışmaya dahil edildi. Kontrol grubu ise 32 sağlıklı kişiden (ortalama yaş 27.9±4.4 yıl, 11 erkek) oluşturuldu. Tüm bireylerde, karotis intima media kalınlığı (CIMT), akım ile ilişkili dilatasyon (FAD %) ve endotel- bağımlı olmayan vazodilatasyon (GTN %) değerlendirildi. CIMT, lümen-intima ile media-adventisya yüzeylerinin önde gelen kenarları arasındaki mesafe olarak hesaplandı. FAD %, reaktif hiperemi sırasında brakiyal arter lümen çapının başlangıç düzeyine göre yüzde değişimi olarak tanımlanırken, GTN % ise, 400 μg gliseriltrinitrat uygulandıktan dört dakika sonra ölçülen brakiyal arter lümen çapının başlangıç düzeyine göre yüzde değişimi olarak tanımlanmıştır. İstatistiksel analiz Student t-testi, Ki-kare testi ve Spearman korelasyon katsayısı analizi ile yapıldı. Bulgular: Her iki grubun CIMT değerleri arasında istatistiksel açıdan anlamlı farklılık yoktur (0.47±0.09’a karşın 0.49±0.06 mm, p=0.138). Ancak, kontrol grubu ile karşılaştırıldığında, çalışma grubundaki kişilerin FAD % değerleri belirgin azalmış olarak saptanmıştır (5.06±4.95’e karşın 10.70±4.64, p<0.001). Buna ilaveten, tezek maruziyeti olan kimselerin GTN % değerleri de kontrol grubuna göre düşük düzeylerde bulunmuştur (14.41±8.47’ye karşın21.85±7.87, p<0.001).

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Kronik biyokütle yakıt dumanı maruziyetinin periferik endotelyal fonksiyonlar üzerindeki etkilerinin değerlendirilmesi: Bir gözlemsel çalışma

Öz:

Objective: To evaluate the effect of chronic biomass fuel (BMF) smoke exposure on peripheral endothelial functions. Methods: Forty-seven healthy subjects who have been exposed to BMF smoke since birth (mean age 31.6±6.8 years, 21 male) were enrolled in the present cross-sectional observational study. The control group consisted of 32 healthy subjects (mean age 27.9±4.4 years, 11 male). The carotid intima media thickness (CIMT), flow associated dilatation (FAD %) and endothelium independent vasodilatation (GTN %) were assessed in all subjects. The carotid CIMT was defined as the distance between the leading edge of the lumen–intima and the media–adventitia interfaces. FAD % was defined as the percentage change in the internal diameter of the brachial artery during reactive hyperemia related to the baseline. GTN % was defined as the change in diameter in response to the application of 400 μg of glyceril trinitrate relative to the baseline scan at the end of the fourth minute. Statistical analysis was performed using Student’s t-test, Chi-square test and Spearman rank order correlation analysis. Results: The average exposure time of the subjects to biomass fuel smoke was 31.7±6.6 years. They have been exposed to dung inhalation products meanly 8.3±1.8 months in a year seasonally. The average daily exposure time was 15.7±3.3 hours. CIMT values of the two groups were not statistically different from each other (0.47±0.09 vs. 0.49±0.06 mm, p=0.138). However, a markedly reduced FAD % was determined in the study group (5.06±4.95 vs. 10.7±4.64, p<0.001). And GTN % of the BMF exposed group was significantly lower than the control group (14.41±8.47 vs. 21.85±7.87, p<0.001). Conclusion: FAD % and GTN % are markedly reduced in the individuals who have been exposed to BMF smoke inhalation products. Therefore, chronic BMF smoke exposure may be a risk factor for the development of endothelial dysfunction. (Anadolu Kardiyol Derg 2011; 11: 492-7)

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BUTURAK A, GENÇ A, ULUS Ö, DUYGU E, ÖKMEN A, UYAREL H (2011). Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. , 492 - 497.
Chicago	BUTURAK ALİ,GENÇ Ahmet,ULUS Özden Sıla,DUYGU Egemen,ÖKMEN Arda Şanlı,UYAREL Hüseyin Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. (2011): 492 - 497.
MLA	BUTURAK ALİ,GENÇ Ahmet,ULUS Özden Sıla,DUYGU Egemen,ÖKMEN Arda Şanlı,UYAREL Hüseyin Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. , 2011, ss.492 - 497.
AMA	BUTURAK A,GENÇ A,ULUS Ö,DUYGU E,ÖKMEN A,UYAREL H Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. . 2011; 492 - 497.
Vancouver	BUTURAK A,GENÇ A,ULUS Ö,DUYGU E,ÖKMEN A,UYAREL H Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. . 2011; 492 - 497.
IEEE	BUTURAK A,GENÇ A,ULUS Ö,DUYGU E,ÖKMEN A,UYAREL H "Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study." , ss.492 - 497, 2011.
ISNAD	BUTURAK, ALİ vd. "Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study". (2011), 492-497.

APA	BUTURAK A, GENÇ A, ULUS Ö, DUYGU E, ÖKMEN A, UYAREL H (2011). Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. Anadolu Kardiyoloji Dergisi, 11(6), 492 - 497.
Chicago	BUTURAK ALİ,GENÇ Ahmet,ULUS Özden Sıla,DUYGU Egemen,ÖKMEN Arda Şanlı,UYAREL Hüseyin Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. Anadolu Kardiyoloji Dergisi 11, no.6 (2011): 492 - 497.
MLA	BUTURAK ALİ,GENÇ Ahmet,ULUS Özden Sıla,DUYGU Egemen,ÖKMEN Arda Şanlı,UYAREL Hüseyin Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. Anadolu Kardiyoloji Dergisi, vol.11, no.6, 2011, ss.492 - 497.
AMA	BUTURAK A,GENÇ A,ULUS Ö,DUYGU E,ÖKMEN A,UYAREL H Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. Anadolu Kardiyoloji Dergisi. 2011; 11(6): 492 - 497.
Vancouver	BUTURAK A,GENÇ A,ULUS Ö,DUYGU E,ÖKMEN A,UYAREL H Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study. Anadolu Kardiyoloji Dergisi. 2011; 11(6): 492 - 497.
IEEE	BUTURAK A,GENÇ A,ULUS Ö,DUYGU E,ÖKMEN A,UYAREL H "Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study." Anadolu Kardiyoloji Dergisi, 11, ss.492 - 497, 2011.
ISNAD	BUTURAK, ALİ vd. "Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study". Anadolu Kardiyoloji Dergisi 11/6 (2011), 492-497.