The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis

UZUNALİMOĞLU, Bedri; CANORUÇ, Fikri; AKCAN, Yusuf; KAYHAN, Burhan; Tuncer, Serdar; KANSU, Emin; ARSLAN, Serap; Ergüven, Sibel; BAKKALOĞLU, Ayşın; ÜNAL, Serhat

The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis

Turkish Journal of Gastroenterology

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Yıl: 2000 Cilt: 11 Sayı: 1 Sayfa Aralığı: 39 - 44 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis

Öz:

Amebik kolitis Entemoeba histolica'nın neden olduğu kolonun iflamatuar bir hastalığıdır. Klasik tedaviye rağmen bazı olgularda semptomlar devam etmekte hastalık kronik forma dönüşebilmektedir. Kronik aktif invaziv amebik kolitis (CAC), tanımlanan bu olgularda, ülseratif kolitisin (UC) birlikte olup olmaması, tedavi ve prognozu belirlemektedir. Bilinen tanı yöntemleri, bu iki hastalığın birlikteliğini tanımlamakta her zaman yeterli olamamaktadır. Bu çalışmada amaç p-ANCA'nın bu ayrımı yapabilecek bir belirleyici olup olmadığını araştırmaktır.Çalışmaya 42 kadın, 53 erkek 95 olgu (yaş aralığı: 20-65) alınmıştır. Yirmisekiz amebik kolitis (AC), 16 UC, 20 kronik amip kolitis ve ülseratif kolitis (CAC&UC) , 11 enfeksiyoz enterit, ve irritable kolon sendromu olan olgulardan oluşan, beş grup tanımlanmıştır. Plazma p-ANCA, Elisa ve IIF (‹ndirekt immün floresan) yöntemlerle saptanmıştır. p-ANCA pozitifliği, UC grubunda %62,5, CAC&UC grubunda %65 bulunmuştur. Bu iki grupta p-ANCA pozitifliği diğer üç gruptan istatistiksel olarak anlamlı fark göstermektedir (p<0.05). Sonuçlar p-ANCA pozitifliğinin kronik aktif amebik kolitis olgularında UC ile beraberliği tanımlamada kullanılabilir bir belirleyici olduğunu göstermektedir. Dirençli olgularda uygun tedavinin planlanmasında p-ANCA yönlendirici olabilir, prognoza olumlu etki ile mortaliteyi azaltabilir.

Anahtar Kelime: Dizanteri, amebik Antikorlar, antinötrofil sitoplazmik Tanı teknikleri, sindirim sistemi Kolon hastalıkları Entamoeba histolytica Kolit Kolit, ülseratif Kronik hastalık p-ANCA Tanı, ayırıcı

Konular: Cerrahi

Kronik amebik kolitin, ülseratif kolit ile birlikte olan amebik kolitten ayrımında p-ANCA'nın değeri

Öz:

Ulcerative colitis is a chronic inflammatory disorder of unknown cause which is only rarely complicated by chronic amebic colitis in the western world. The aim of this clinical study was to determine the significiance of p-ANCA positivity in differentiating amebic colitis from ulcerative colitis complicated by chronic amebic colitis.During a two-year period, between 1995-1997, a total of 95 patients including 16 patients with ulcerative colitis (UC), 20 patients with UC complicated by chronic amebic colitis (CAC&UC), 28 patients with pure amebic colitis (AC), 11 patients with infectious enteritis (IE) and 20 patients with irritable bowel syndrome were seen and evaluated with all available radiologic, serologic, immunologic, microbiologic (parasitologic), and pathologic studies. In eight patients with UC and 12 patients with chronic amebic colitis as an initial diagnosis complete remission could not be accomplished by a vigorous treatment regimen. In those 20 patients, a co-existing ulcerative colitis and amebic colitis was suspected. (CAC&UC). In order to differentiate these and evaluate their diagnostic value, serum p-ANCA was tested in those 20 and the remaining 75 patients in addition to performance of radiologic, histologic and serologic tests.The rates of p-ANCA positivity were as follows: 62.5% for UC, 65 % for UC complicated with CAC, 14.2 % for pure CAC, and 0% for irritable bowel syndrome and infectious enteritis. The differences of p-ANCA positivity rates were significant in patients with UC and UC complicated with CAC in comparison by pure CAC, infectious enteritis and irritable bowel syndrome (p<0.05).p-ANCA can be used as a serological marker in differentiating amebic colitis from ulcerative colitis complicated by amebic colitis. This test should be used in countries where amebic colitis is endemic.

Anahtar Kelime: Entamoeba histolytica Colitis Colitis, Ulcerative Chronic Disease p-ANCA Diagnosis, Differential Dysentery, Amebic Antibodies, Antineutrophil Cytoplasmic Diagnostic Techniques, Digestive System Colonic Diseases

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

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APA	ARSLAN S, AKCAN Y, BAKKALOĞLU A, Tuncer S, KANSU E, ÜNAL S, Ergüven S, CANORUÇ F, UZUNALİMOĞLU B, KAYHAN B (2000). The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. , 39 - 44.
Chicago	ARSLAN Serap,AKCAN Yusuf,BAKKALOĞLU Ayşın,Tuncer Serdar,KANSU Emin,ÜNAL Serhat,Ergüven Sibel,CANORUÇ Fikri,UZUNALİMOĞLU Bedri,KAYHAN Burhan The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. (2000): 39 - 44.
MLA	ARSLAN Serap,AKCAN Yusuf,BAKKALOĞLU Ayşın,Tuncer Serdar,KANSU Emin,ÜNAL Serhat,Ergüven Sibel,CANORUÇ Fikri,UZUNALİMOĞLU Bedri,KAYHAN Burhan The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. , 2000, ss.39 - 44.
AMA	ARSLAN S,AKCAN Y,BAKKALOĞLU A,Tuncer S,KANSU E,ÜNAL S,Ergüven S,CANORUÇ F,UZUNALİMOĞLU B,KAYHAN B The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. . 2000; 39 - 44.
Vancouver	ARSLAN S,AKCAN Y,BAKKALOĞLU A,Tuncer S,KANSU E,ÜNAL S,Ergüven S,CANORUÇ F,UZUNALİMOĞLU B,KAYHAN B The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. . 2000; 39 - 44.
IEEE	ARSLAN S,AKCAN Y,BAKKALOĞLU A,Tuncer S,KANSU E,ÜNAL S,Ergüven S,CANORUÇ F,UZUNALİMOĞLU B,KAYHAN B "The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis." , ss.39 - 44, 2000.
ISNAD	ARSLAN, Serap vd. "The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis". (2000), 39-44.

APA	ARSLAN S, AKCAN Y, BAKKALOĞLU A, Tuncer S, KANSU E, ÜNAL S, Ergüven S, CANORUÇ F, UZUNALİMOĞLU B, KAYHAN B (2000). The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. Turkish Journal of Gastroenterology, 11(1), 39 - 44.
Chicago	ARSLAN Serap,AKCAN Yusuf,BAKKALOĞLU Ayşın,Tuncer Serdar,KANSU Emin,ÜNAL Serhat,Ergüven Sibel,CANORUÇ Fikri,UZUNALİMOĞLU Bedri,KAYHAN Burhan The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. Turkish Journal of Gastroenterology 11, no.1 (2000): 39 - 44.
MLA	ARSLAN Serap,AKCAN Yusuf,BAKKALOĞLU Ayşın,Tuncer Serdar,KANSU Emin,ÜNAL Serhat,Ergüven Sibel,CANORUÇ Fikri,UZUNALİMOĞLU Bedri,KAYHAN Burhan The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. Turkish Journal of Gastroenterology, vol.11, no.1, 2000, ss.39 - 44.
AMA	ARSLAN S,AKCAN Y,BAKKALOĞLU A,Tuncer S,KANSU E,ÜNAL S,Ergüven S,CANORUÇ F,UZUNALİMOĞLU B,KAYHAN B The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. Turkish Journal of Gastroenterology. 2000; 11(1): 39 - 44.
Vancouver	ARSLAN S,AKCAN Y,BAKKALOĞLU A,Tuncer S,KANSU E,ÜNAL S,Ergüven S,CANORUÇ F,UZUNALİMOĞLU B,KAYHAN B The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis. Turkish Journal of Gastroenterology. 2000; 11(1): 39 - 44.
IEEE	ARSLAN S,AKCAN Y,BAKKALOĞLU A,Tuncer S,KANSU E,ÜNAL S,Ergüven S,CANORUÇ F,UZUNALİMOĞLU B,KAYHAN B "The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis." Turkish Journal of Gastroenterology, 11, ss.39 - 44, 2000.
ISNAD	ARSLAN, Serap vd. "The significance of p-ANCA in differing chronic amebic colitis from ulcerative colitis complicated with amebic colitis". Turkish Journal of Gastroenterology 11/1 (2000), 39-44.