Synthesis and anticancer activity of some bisquinoxaline derivatives

İNCESU, Zerrin; Işıkdağ, İlhan; Özkay, Yusuf

Synthesis and anticancer activity of some bisquinoxaline derivatives

İlhan IŞIKDAĞ, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Eskişehir, Türkiye)

Yusuf ÖZKAY, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Eskişehir, Türkiye)

Zerrin İNCESU (Anadolu Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı, Eskişehir, Türkiye)

Turkish Journal of Pharmaceutical Sciences

2 1

Yıl: 2011 Cilt: 8 Sayı: 2 Sayfa Aralığı: 179 - 188 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Synthesis and anticancer activity of some bisquinoxaline derivatives

Öz:

Mevcut antikanser ajanlara karşı rezistans gelişimi, yeni antikanser ajanlar için bir araştırma alanı yaratmaktadır. Bununla birlikte, normal hücreler üzerinde etki göstermeden ya da en az etkiyle anormal hücrelerin çoğalmasını seçici olarak inhibe edebilecek yeni bir ajanın geliştirilmesi oldukça güçtür. Bu nedenle, kanser kemoterapisi medisinal kimyacılar için çok önemlidir ve çeşitli kanser tipleri üzerinde antikanser aktivite gösterme olasılığı bulunan yeni kemoterapötik ajanların geliştirilmesi üzerinde çalışmalar halen devam etmektedir. Bu noktadan hareketle, bu çalışmada bazı biskinoksalin türevleri sentezlenmiş ve HT-29 (kolon kanseri) ve MCF-7 (göğüs kanseri) hücre hatları üzerinde antikanser aktiviteleri için taranmıştır. Sentezlenen bileşiklerden bazıları (3e ve 3l) MCF-7 hücre hattı üzerinde önemli sitotoksisite ve DNA sentez inhibisyonu göstermiştir.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Bazı biskinoksalin türevlerinin sentezleri ve antikanser aktiviteleri

Öz:

Resistance improvement against the existing anticancer agents creates a research area for new anticancer agents. Nevertheless, it is rather difficult to develop a new agent which can selectively inhibit the proliferation of abnormal cells with least or no affect on normal cells. Therefore, cancer chemotherapy is very important for medicinal chemists and the studies are still being carried on to develop new chemotherapeutic agents that are probable to indicate activity on various cancer types. Depending on this point, in this study some bisquinoxaline derivatives were synthesized and screened for their anticancer activity on HT-29 (colon carcinoma) and MCF-7(breast carcinoma) cell lines. Some of the synthesized compounds (3e and 3l) showed significant cytotoxicity and DNA synthesis inhibition on MCF-7 cell line.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Işıkdağ İ, Özkay Y, İNCESU Z (2011). Synthesis and anticancer activity of some bisquinoxaline derivatives. , 179 - 188.
Chicago	Işıkdağ İlhan,Özkay Yusuf,İNCESU Zerrin Synthesis and anticancer activity of some bisquinoxaline derivatives. (2011): 179 - 188.
MLA	Işıkdağ İlhan,Özkay Yusuf,İNCESU Zerrin Synthesis and anticancer activity of some bisquinoxaline derivatives. , 2011, ss.179 - 188.
AMA	Işıkdağ İ,Özkay Y,İNCESU Z Synthesis and anticancer activity of some bisquinoxaline derivatives. . 2011; 179 - 188.
Vancouver	Işıkdağ İ,Özkay Y,İNCESU Z Synthesis and anticancer activity of some bisquinoxaline derivatives. . 2011; 179 - 188.
IEEE	Işıkdağ İ,Özkay Y,İNCESU Z "Synthesis and anticancer activity of some bisquinoxaline derivatives." , ss.179 - 188, 2011.
ISNAD	Işıkdağ, İlhan vd. "Synthesis and anticancer activity of some bisquinoxaline derivatives". (2011), 179-188.

APA	Işıkdağ İ, Özkay Y, İNCESU Z (2011). Synthesis and anticancer activity of some bisquinoxaline derivatives. Turkish Journal of Pharmaceutical Sciences, 8(2), 179 - 188.
Chicago	Işıkdağ İlhan,Özkay Yusuf,İNCESU Zerrin Synthesis and anticancer activity of some bisquinoxaline derivatives. Turkish Journal of Pharmaceutical Sciences 8, no.2 (2011): 179 - 188.
MLA	Işıkdağ İlhan,Özkay Yusuf,İNCESU Zerrin Synthesis and anticancer activity of some bisquinoxaline derivatives. Turkish Journal of Pharmaceutical Sciences, vol.8, no.2, 2011, ss.179 - 188.
AMA	Işıkdağ İ,Özkay Y,İNCESU Z Synthesis and anticancer activity of some bisquinoxaline derivatives. Turkish Journal of Pharmaceutical Sciences. 2011; 8(2): 179 - 188.
Vancouver	Işıkdağ İ,Özkay Y,İNCESU Z Synthesis and anticancer activity of some bisquinoxaline derivatives. Turkish Journal of Pharmaceutical Sciences. 2011; 8(2): 179 - 188.
IEEE	Işıkdağ İ,Özkay Y,İNCESU Z "Synthesis and anticancer activity of some bisquinoxaline derivatives." Turkish Journal of Pharmaceutical Sciences, 8, ss.179 - 188, 2011.
ISNAD	Işıkdağ, İlhan vd. "Synthesis and anticancer activity of some bisquinoxaline derivatives". Turkish Journal of Pharmaceutical Sciences 8/2 (2011), 179-188.