N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study

TAYYAR, Şenol; ÖZAYDIN, Mehmet; Dogan, Abdullah; VAROL, ERCAN; İÇLİ, Atilla; ERDOĞAN, Doğan; Uysal, Bayram Ali; ARSLAN, Akif; ÖZKAN ÜNAL, EMEL; TÜRKER, Yasin

N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study

Mehmet ÖZAYDIN, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

Doğan ERDOĞAN, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

Şenol TAYYAR, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

Bayram Ali UYSAL, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

Abdullah DOĞAN, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

Atilla İÇLİ, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

EMEL ÖZKAN ÜNAL, (Gülkent Devlet Hastanesi, Kardiyoloji Kliniği, Isparta, Türkiye)

Ercan VAROL, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

Yasin TÜRKER, (Gülkent Devlet Hastanesi, Kardiyoloji Kliniği, Isparta, Türkiye)

Akif ARSLAN (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

Anadolu Kardiyoloji Dergisi

0 1

Yıl: 2011 Cilt: 11 Sayı: 4 Sayfa Aralığı: 305 - 309 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study

Öz:

Amaç: Bu prospektif randomize çalışmanın amacı, n-3 çoklu doymamış yağ asitlerinin elektriksel kardiyoversiyon sonrası atriyal fibrilasyon (AF) nüksü üzerine olan etkilerini araştırmaktır.Yöntemler: Gerekli hasta sayısı, sinüs ritmi idamesinin amiyodaron grubunda %20, yağ asidi grubunda %65 olacağı tahmin edilerek hesaplandı. Alfa değeri 0.05 ve güç %80 olacak şekilde anlamlı sonuç elde etmek için her bir grupta 22 hastanın gerekli olduğu bulundu. Toplam 47 hasta elektriksel kardiyoversiyon öncesi amiyodaron (n=24) ve amiyodaron+n-3 çoklu doymamış yağ asidi (n=23) gruplarına randomize edildiler. Sonlanım noktası 12 aylık takipte AF nüksü olarak belirlendi. N-3 çoklu doymamış yağ asitlerinin inflamasyon üzerine olan etkisi C-reaktif protein düzeylerinin ölçülmesi ile değerlendirildi. İstatistiksel analiz eşleştirilmemiş Student t-testi, Mann-Whitney U testi Ki-kare testi ile yapıldı. Atriyal fibrilasyon nüksü, potansiyel etkili faktörleri kontrol ederek Cox oransal regresyon modeli ile değerlendirildi. Bulgular: Amiyodaron grubundaki 9 hastada (%37.5) ve amiyodaron+n-3 çoklu doymamış yağ asidi grubundaki 9 hastada (%39.1) nüks gözlendi (p=1). Cox regresyon analizinde, nüks için risk faktörleri önceden elektriksel kardiyoversiyon yapılmış olması (izafi risk 10.33; %95 GA 1.74-61.10; p=0.01) ve yüksek duyarlıklı C-reaktif protein düzeyleri (izafi risk 1.07, %95 GA 1.02-1.38, p=0.007) olarak bulundu. Bazal, 15.günde ve nüks sırasında bakılan çok duyarlı C-reaktif protein düzeyleri iki grupta benzerdi (tümü için p>0.05).Sonuç: Çoklu doymamış yağ asidi kullanılmasının atriyal fibrilasyon nüksü ve inflamasyon üzerine bir etkisi tespit edilmemiştir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

N-3 çoklu doymamış yağ asitlerinin kullanımı elektriksel kardiyoversiyon sonrası inflamasyon ve atriyal fibrilasyon nüks oranlarını azaltmaz: Prospektif randomize bir çalışma

Öz:

Objective: The purpose of the present prospective randomized study was to evaluate the effects of n-3 polyunsaturated fatty acids on recurrence rates of atrial fibrillation (AF) and inflammation after electrical cardioversion.Methods: Calculation of the number of patients needed was based on the assumption of 20% and 65% chance of maintaining sinus rhythm with amiodarone and with polyunsaturated fatty acids, respectively. To observe a significant difference with an alpha level of 0.05 and a power of 0.80 it was necessary to include 22 patients in each group. A total of 47 patients were randomized to amiodarone (n=24) and amiodarone plus n-3 polyunsaturated fatty acids (n=23) groups before scheduled electrical cardioversion. The end-point was the recurrence of AF during 12-month follow-up. Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Statistical analysis was performed using unpaired Student’ t, Mann Whitney U and Chi-square tests. We analyzed the recurrence of AF using the Cox proportional hazards regression model to control for potentially confounding factors. Results: Nine patients in the amiodarone group (37.5%), and 9 patients in the amiodarone plus n-3 polyunsaturated fatty acids group (39.1%) had recurrence of AF during follow-up (p=1). With the Cox proportional model, risk factors for the recurrence of AF were previous electrical cardioversion (HR 10.33, 95% CI 1.74 to 61.10, p=0.01) and high sensitivity C-reactive protein levels (HR 1.07, 95% CI 1.02 to 1.38, p=0.007). High sensitivity C-reactive protein levels at baseline, at day 15 and during AF recurrence were similar between two groups (p > 0.05 for all).Conclusion: N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZAYDIN M, ERDOĞAN D, TAYYAR Ş, Uysal B, Dogan A, İÇLİ A, ÖZKAN ÜNAL E, VAROL E, TÜRKER Y, ARSLAN A (2011). N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. , 305 - 309.
Chicago	ÖZAYDIN Mehmet,ERDOĞAN Doğan,TAYYAR Şenol,Uysal Bayram Ali,Dogan Abdullah,İÇLİ Atilla,ÖZKAN ÜNAL EMEL,VAROL ERCAN,TÜRKER Yasin,ARSLAN Akif N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. (2011): 305 - 309.
MLA	ÖZAYDIN Mehmet,ERDOĞAN Doğan,TAYYAR Şenol,Uysal Bayram Ali,Dogan Abdullah,İÇLİ Atilla,ÖZKAN ÜNAL EMEL,VAROL ERCAN,TÜRKER Yasin,ARSLAN Akif N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. , 2011, ss.305 - 309.
AMA	ÖZAYDIN M,ERDOĞAN D,TAYYAR Ş,Uysal B,Dogan A,İÇLİ A,ÖZKAN ÜNAL E,VAROL E,TÜRKER Y,ARSLAN A N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. . 2011; 305 - 309.
Vancouver	ÖZAYDIN M,ERDOĞAN D,TAYYAR Ş,Uysal B,Dogan A,İÇLİ A,ÖZKAN ÜNAL E,VAROL E,TÜRKER Y,ARSLAN A N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. . 2011; 305 - 309.
IEEE	ÖZAYDIN M,ERDOĞAN D,TAYYAR Ş,Uysal B,Dogan A,İÇLİ A,ÖZKAN ÜNAL E,VAROL E,TÜRKER Y,ARSLAN A "N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study." , ss.305 - 309, 2011.
ISNAD	ÖZAYDIN, Mehmet vd. "N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study". (2011), 305-309.

APA	ÖZAYDIN M, ERDOĞAN D, TAYYAR Ş, Uysal B, Dogan A, İÇLİ A, ÖZKAN ÜNAL E, VAROL E, TÜRKER Y, ARSLAN A (2011). N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. Anadolu Kardiyoloji Dergisi, 11(4), 305 - 309.
Chicago	ÖZAYDIN Mehmet,ERDOĞAN Doğan,TAYYAR Şenol,Uysal Bayram Ali,Dogan Abdullah,İÇLİ Atilla,ÖZKAN ÜNAL EMEL,VAROL ERCAN,TÜRKER Yasin,ARSLAN Akif N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. Anadolu Kardiyoloji Dergisi 11, no.4 (2011): 305 - 309.
MLA	ÖZAYDIN Mehmet,ERDOĞAN Doğan,TAYYAR Şenol,Uysal Bayram Ali,Dogan Abdullah,İÇLİ Atilla,ÖZKAN ÜNAL EMEL,VAROL ERCAN,TÜRKER Yasin,ARSLAN Akif N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. Anadolu Kardiyoloji Dergisi, vol.11, no.4, 2011, ss.305 - 309.
AMA	ÖZAYDIN M,ERDOĞAN D,TAYYAR Ş,Uysal B,Dogan A,İÇLİ A,ÖZKAN ÜNAL E,VAROL E,TÜRKER Y,ARSLAN A N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. Anadolu Kardiyoloji Dergisi. 2011; 11(4): 305 - 309.
Vancouver	ÖZAYDIN M,ERDOĞAN D,TAYYAR Ş,Uysal B,Dogan A,İÇLİ A,ÖZKAN ÜNAL E,VAROL E,TÜRKER Y,ARSLAN A N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study. Anadolu Kardiyoloji Dergisi. 2011; 11(4): 305 - 309.
IEEE	ÖZAYDIN M,ERDOĞAN D,TAYYAR Ş,Uysal B,Dogan A,İÇLİ A,ÖZKAN ÜNAL E,VAROL E,TÜRKER Y,ARSLAN A "N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study." Anadolu Kardiyoloji Dergisi, 11, ss.305 - 309, 2011.
ISNAD	ÖZAYDIN, Mehmet vd. "N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: A prospective randomized study". Anadolu Kardiyoloji Dergisi 11/4 (2011), 305-309.