TY  - JOUR
TI  - Prognostic significance of Wilms tumor 1 gene in childhood acute lymphoblastic leukemia
AB  - Wilms tumor 1 (WT1) gene is a tumor supressor gene, expressed in malignant and normal hematopoietic progenitor cells. Prognostic significance of this gene in childhood acute lymphoid leukemia (ALL) is not clear. We evaluated the presence of WT1 expression in bone marrow samples of 28 children with de novo ALL at diagnosis by two step RT-PCR. Expression of WT1 gene was detected in 78.5% of patients. There was no correlation between WT1 gene expression and age, sex, FAB type, leukocyte count, and presence of t(4;11) and t(9;22). All patients were treated with modified BFM 86 protocol. There was no difference in the complete remission (CR) rate between WT1 positive and negative patients. Event free survival (EFS) and overall survival (OS) of WT1 positive and negative patients were also not significant. We conclude that expression of WT1 gene is not associated with specific characteristics of ALL blast cells and is not a prognostic factor for CR, remission duration and overall survival.
AU  - OZGEN, ÜNSAL
AU  - Anak, Seniye Sema
AU  - ÖZBEK, Uğur
AU  - Sarper, Nazan
AU  - ERYILMAZ, Ertuğrul
AU  - AĞAOĞLU, Leyla
AU  - DEVECİOĞLU, Ömer
AU  - YALMAN, Nevin
AU  - GEDİKOĞLU, Gündüz
PY  - 2000
JO  - Turkish Journal of Hematology
VL  - 17
IS  - 4
SN  - 1300-7777
SP  - 183
EP  - 188
DB  - TRDizin
UR  - http://search/yayin/detay/12619
ER  -