Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity

Gündoğdu, Cemal; yakan, birkan; BAŞOĞLU, Mahmut; TONBUL, H. Zeki; SAN, Ayla; KIZILTUNÇ, Ahmet; SELÇUK, N. Yılmaz

Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity

N. Yılmaz SELÇUK, (Atatürk Üniversitesi, Tıp Fakültesi, Nefroloji Anabilim Dalı, Erzurum, Türkiye)

Birkan YAKAN, (Girilmedi)

Mahmut BAŞOĞLU, (Girilmedi)

Cemal GÜNDOĞDU, (Girilmedi)

Ahmet KIZILTUNÇ, (Girilmedi)

H. Zeki TONBUL, (Girilmedi)

Ayla SAN (Girilmedi)

Turkish Journal of Medical Sciences

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Yıl: 2000 Cilt: 30 Sayı: 2 Sayfa Aralığı: 109 - 113 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity

Öz:

In recent years, Endothelin-1 (ET-1), Platelet Activating Factor (PAF) and thromboxane have been considered responsible for the pathogenesis of acute cyclosporine nephrotoxicity (ACN). The aim of this study was to investigate the effects of the PAF antagonist gingko glycosid (EGb 761) on both renal histology and ET-1 and Nitric Oxide (NO) levels in experimental ACN. This study was carried out on 30 albino rabbits, divided into three groups. They were: group A (n=10) the control, group B (n=10), which was given intravenous cyclosporine (15mg/kg/day) and group C (n=10), which was given oral gingko glycosid (2.5mg/kg/day) in addition to cyclosporine. Plasma ET-1 and NO levels and renal histology were investigated in all of the groups. Data analysis was performed by ruskall-Wallis one-way Anova and Mann Whitney-U tests. Plasma ET-1 levels in groups B and C were higher than in the controls (p<0.0002, p<0.0002, respectively). Plasma NO levels in groups B and C were lower than in the controls (p<0.0002, p<0.0047, respectively). However, group C had high NO levels and low ET-1 levels compared to group B (p<0.004, p<0.0002, respectively). Renal histological findings of ACN were observed in group B, and to a lesser extent in group C. Consequently, it was established that the PAF antagonist Gingko glycosid Egb 761 partially improved both the renal histology and plasma ET-1 and NO levels in experimental ACN.

Anahtar Kelime: Kidney Transplantation Plant Extracts EGb 761 Nephrotoxicity Histology Glycosides Cyclosporine Ginkgo biloba Platelet Activating Factor Gingko glycoside Drug Toxicity Endothelin-1 Nitric Oxide Renal histology Kidney Diseases Experimental diseases Acute Disease Kidney Thromboxanes Rabbits Endothelium, Vascular

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

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APA	SELÇUK N, yakan b, BAŞOĞLU M, Gündoğdu C, KIZILTUNÇ A, TONBUL H, SAN A (2000). Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. , 109 - 113.
Chicago	SELÇUK N. Yılmaz,yakan birkan,BAŞOĞLU Mahmut,Gündoğdu Cemal,KIZILTUNÇ Ahmet,TONBUL H. Zeki,SAN Ayla Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. (2000): 109 - 113.
MLA	SELÇUK N. Yılmaz,yakan birkan,BAŞOĞLU Mahmut,Gündoğdu Cemal,KIZILTUNÇ Ahmet,TONBUL H. Zeki,SAN Ayla Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. , 2000, ss.109 - 113.
AMA	SELÇUK N,yakan b,BAŞOĞLU M,Gündoğdu C,KIZILTUNÇ A,TONBUL H,SAN A Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. . 2000; 109 - 113.
Vancouver	SELÇUK N,yakan b,BAŞOĞLU M,Gündoğdu C,KIZILTUNÇ A,TONBUL H,SAN A Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. . 2000; 109 - 113.
IEEE	SELÇUK N,yakan b,BAŞOĞLU M,Gündoğdu C,KIZILTUNÇ A,TONBUL H,SAN A "Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity." , ss.109 - 113, 2000.
ISNAD	SELÇUK, N. Yılmaz vd. "Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity". (2000), 109-113.

APA	SELÇUK N, yakan b, BAŞOĞLU M, Gündoğdu C, KIZILTUNÇ A, TONBUL H, SAN A (2000). Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. Turkish Journal of Medical Sciences, 30(2), 109 - 113.
Chicago	SELÇUK N. Yılmaz,yakan birkan,BAŞOĞLU Mahmut,Gündoğdu Cemal,KIZILTUNÇ Ahmet,TONBUL H. Zeki,SAN Ayla Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. Turkish Journal of Medical Sciences 30, no.2 (2000): 109 - 113.
MLA	SELÇUK N. Yılmaz,yakan birkan,BAŞOĞLU Mahmut,Gündoğdu Cemal,KIZILTUNÇ Ahmet,TONBUL H. Zeki,SAN Ayla Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. Turkish Journal of Medical Sciences, vol.30, no.2, 2000, ss.109 - 113.
AMA	SELÇUK N,yakan b,BAŞOĞLU M,Gündoğdu C,KIZILTUNÇ A,TONBUL H,SAN A Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. Turkish Journal of Medical Sciences. 2000; 30(2): 109 - 113.
Vancouver	SELÇUK N,yakan b,BAŞOĞLU M,Gündoğdu C,KIZILTUNÇ A,TONBUL H,SAN A Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity. Turkish Journal of Medical Sciences. 2000; 30(2): 109 - 113.
IEEE	SELÇUK N,yakan b,BAŞOĞLU M,Gündoğdu C,KIZILTUNÇ A,TONBUL H,SAN A "Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity." Turkish Journal of Medical Sciences, 30, ss.109 - 113, 2000.
ISNAD	SELÇUK, N. Yılmaz vd. "Effects of gingko glycosid (EGb 761) on some vascular endothelial functions and renal histology in rabbits with acute cyclosporine nephrotoxicity". Turkish Journal of Medical Sciences 30/2 (2000), 109-113.