Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation

YILMAZ, MEHMET BIRHAN; GURAY, UMIT; ŞAŞMAZ, Ali; KORKMAZ, Şule; Demirkan, Burcu; EGE, Meltem; GÜRAY, Yeşim

Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation

Meltem EGE, (Yalova Devlet Hastanesi, Kardiyoloji Kliniği, Yalova, Türkiye)

Ümit GÜRAY, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Yeşim GÜRAY, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Mehmet Birhan YILMAZ, (Cumhuriyet Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Sivas, Türkiye)

Burcu DEMİRKAN, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Ali ŞAŞMAZ, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Şule KORKMAZ (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Anadolu Kardiyoloji Dergisi

2 1

Yıl: 2011 Cilt: 11 Sayı: 3 Sayfa Aralığı: 213 - 217 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation

Öz:

Amaç: Akut miyokart enfarktüsü ile başvuran hastalarda hiperglisemi olumsuz prognozla ilişkilidir. Primer perkütan koroner girişim (PKG) yapılan hastalarda, enfarkttan sorumlu arterin işlem sonu Miyokart Enfarktüste Trombolizis (TIMI) kare sayıları başarılı reperfüzyona rağmen önemli oranda farklılık gösterebilmektedir. Bu prospektif gözlemsel çalışmada ST yükselmeli miyokart enfarktüsü (STYMİ) sebebi ile başarılı primer PKG uygulanan hastalarda başvuru glikoz değerleri ile işlem sonucunda sorumlu koroner arter TIMI kare sayılarının ilişkisi araştırılmıştır.Yöntemler: Altı aylık zaman süresi içerisinde, STYMİ ile başvuran ve PKG ile TIMI 3 akım sağlanan ardışık 73 diyabetes mellitusu olmayan hasta çalışmaya dahil edilmiştir. Hastalar TIMI kare sayılarına göre iki gruba bölünmüştür. Grup 1 (n=53), enfarkttan sorumlu koroner arter TIMI kare sayıları daha önceden belirlenmiş değerlerin iki standart sapması içine giren hastalardan, Grup 2 (n=20) ise yüksek TIMI kare sayısına sahip hastalardan oluşmuştur. İstatistiksel analiz Ki-kare, Mann-Whitney U testleri ve çoklu doğrusal regresyon analizi ile gerçekleştirildi.Bulgular: Benzer açlık glikoz değerlerine rağmen, başvuru kan şekeri değerleri Grup 2 hastalarında Grup 1’e göre anlamlı şekilde daha yüksekti (138 [114-165]’e karşılık 123 [97-143] mg/dl, p=0.03). Tüm grupta başvuru glikoz değerleri ile sorumlu koroner arter düzeltilmiş TIMI kare sayısı arasında anlamlı pozitif korelasyon izlendi (r=0.30, p=0.01). Aynı zamanda, başvuru glikoz değeri ile hem zirve kreatin kinaz-MB (r=0.36, p=0.007) hem de sol ventriküler ejeksiyon fraksiyonu arasında anlamlı korelasyon saptandı (r=-0.43, p=0.009). Çoklu lineer regresyon analizinde incelenen parametrelerden (başvuru glikozu, beyaz küre sayısı, zirve kreatin kinaz-MB ve sol ventrikül ejeksiyon fraksiyonu), sadece başvuru glikozu infarkt arterinin nihai TIMI kare sayısı ile ilişkili olduğu saptandı (β=0.04, %95 GA:0.02-0.085, p=0.04).Sonuç: Yüksek başvuru kan şekeri değerleri, başarılı primer PKG uygulanan diyabetes mellitusu olmayan hastalarda bile işlem sonrası bozulmuş koroner akım ile ilişkilidir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Başarılı perkütan koroner girişim uygulanan akut ST yükselmeli miyokart enfarktüslü hastalarda başvuru glikoz düzeyleri ve TIMI kare sayısı arasındaki ilişki

Öz:

Objective: Admission hyperglycemia is associated with poor prognosis in patients with acute myocardial infarction. Final Thrombolysis in Myocardial Infarction (TIMI) frame counts of culprit coronary arteries may show significant variability despite successful coronary reperfusion after primary percutaneous coronary intervention (PCI). In this prospective observational study, relationship between final TIMI frame counts of the culprit coronary artery and admission glucose values was investigated in patients who underwent successful primary PCI due to acute ST-elevation myocardial infarction (STEMI).Methods: During a 6- month period of time, 73 non-diabetic patients presented with acute STEMI who have undergone primary PCI with final TIMI 3 flow were consecutively included in the study. Patients were divided into two groups according to final TIMI frame counts. Group 1 (n=53) consisted of patients with final TIMI frame counts of the culprit coronary artery within the two standard deviation of predefined values and Group 2 (n=20) consisted of those with higher TIMI frame counts. Statistical analysis was performed using Chi-square, Mann-Whitney U tests and multiple linear regression analysis.Results: Despite similar fasting glucose values, admission glucose levels were significantly higher in Group 2 as compared to Group 1 (138 [114-165] vs. 123 [97-143] mg/dl, p=0.03). In whole group, admission glucose values were significantly correlated with corrected TIMI frame counts of culprit coronary arteries (r=0.30, p=0.01). In addition, there were significant association between admission glucose values and peak creatine kinase-MB (r=0.36, p=0.007) values as well as left ventricular ejection fraction (r=-0.43, p=0.009). In multiple linear regression analysis, only admission glucose value was found to be significantly related to the final TIMI frame count of the culprit artery (β=0.04, 95% CI: 0.02-0.085, p=0.04). Conclusion: High admission glucose values were significantly associated with impaired coronary flow even after successful primary PCI in non-diabetic patients with STEMI.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	EGE M, GURAY U, GÜRAY Y, YILMAZ M, Demirkan B, ŞAŞMAZ A, KORKMAZ Ş (2011). Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. , 213 - 217.
Chicago	EGE Meltem,GURAY UMIT,GÜRAY Yeşim,YILMAZ MEHMET BIRHAN,Demirkan Burcu,ŞAŞMAZ Ali,KORKMAZ Şule Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. (2011): 213 - 217.
MLA	EGE Meltem,GURAY UMIT,GÜRAY Yeşim,YILMAZ MEHMET BIRHAN,Demirkan Burcu,ŞAŞMAZ Ali,KORKMAZ Şule Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. , 2011, ss.213 - 217.
AMA	EGE M,GURAY U,GÜRAY Y,YILMAZ M,Demirkan B,ŞAŞMAZ A,KORKMAZ Ş Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. . 2011; 213 - 217.
Vancouver	EGE M,GURAY U,GÜRAY Y,YILMAZ M,Demirkan B,ŞAŞMAZ A,KORKMAZ Ş Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. . 2011; 213 - 217.
IEEE	EGE M,GURAY U,GÜRAY Y,YILMAZ M,Demirkan B,ŞAŞMAZ A,KORKMAZ Ş "Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation." , ss.213 - 217, 2011.
ISNAD	EGE, Meltem vd. "Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation". (2011), 213-217.

APA	EGE M, GURAY U, GÜRAY Y, YILMAZ M, Demirkan B, ŞAŞMAZ A, KORKMAZ Ş (2011). Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. Anadolu Kardiyoloji Dergisi, 11(3), 213 - 217.
Chicago	EGE Meltem,GURAY UMIT,GÜRAY Yeşim,YILMAZ MEHMET BIRHAN,Demirkan Burcu,ŞAŞMAZ Ali,KORKMAZ Şule Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. Anadolu Kardiyoloji Dergisi 11, no.3 (2011): 213 - 217.
MLA	EGE Meltem,GURAY UMIT,GÜRAY Yeşim,YILMAZ MEHMET BIRHAN,Demirkan Burcu,ŞAŞMAZ Ali,KORKMAZ Şule Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. Anadolu Kardiyoloji Dergisi, vol.11, no.3, 2011, ss.213 - 217.
AMA	EGE M,GURAY U,GÜRAY Y,YILMAZ M,Demirkan B,ŞAŞMAZ A,KORKMAZ Ş Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. Anadolu Kardiyoloji Dergisi. 2011; 11(3): 213 - 217.
Vancouver	EGE M,GURAY U,GÜRAY Y,YILMAZ M,Demirkan B,ŞAŞMAZ A,KORKMAZ Ş Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation. Anadolu Kardiyoloji Dergisi. 2011; 11(3): 213 - 217.
IEEE	EGE M,GURAY U,GÜRAY Y,YILMAZ M,Demirkan B,ŞAŞMAZ A,KORKMAZ Ş "Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation." Anadolu Kardiyoloji Dergisi, 11, ss.213 - 217, 2011.
ISNAD	EGE, Meltem vd. "Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention - Original Investigation". Anadolu Kardiyoloji Dergisi 11/3 (2011), 213-217.