Yıl: 2011 Cilt: 25 Sayı: 3 Sayfa Aralığı: 189 - 199 Metin Dili: Türkçe

WNT/Beta-katenin sinyal yolunun sitoplazmik biyomolekülleri

Öz:
Omurgasızlardan omurgalılara kadar evrimsel olarak oldukça korunan Wnt/β-katenin sinyal yolu hem erken embriyonik gelişimin düzenlenmesinde, hem de erişkin dokularda apoptozis, adipogenez, anjiogenez, sinaps oluşumu gibi olaylarda rol almaktadır. Bununla birlikte bu sinyal yolunda meydana gelen bozuklukların kanser başta olmak üzere birçok ciddi hastalığın etiyolojisinde rolü olduğunun düşünülmesi, son yıllarda bu sinyal yolu ile ilgili araştırmaları oldukça arttırmıştır. Wnt/β-katenin sinyal yolunun bu hastalıklardaki rolünü belirlemeye yönelik çalışmalarda çoğunlukla β- katenin, Axin, Adenomatöz Polipozis Koli (APC) gibi biyomoleküller araştırılmaktadır. Ayrıca, bu biyomoleküller sadece hastalıkların oluşum mekanizmalarının belirlenmesinde değil, bu hastalıkların tedavisinde hedef olarak da kullanılmakta-dırlar. Dolayısıyla Wnt/β-katenin sinyal yolunun en önemli basamağı olan sitoplazmik reaksiyonların ve bu reaksiyonlarda görev alan biyomoleküllerin ortaya konulması sinyal yolunun bütünün tam olarak anlaşılması için oldukça önemlidir. Bu sebeple derlememizde hedef hücre sitoplazmasında görev yapan biyomoleküllerin tartışılması ve bu şekilde sinyal yolunun tam olarak aydınlatılması amaçlanmıştır.
Anahtar Kelime:

Konular:
Fen > Tıp > Anatomi ve Morfoloji
Fen > Tıp > Androloji
Fen > Tıp > Biyofizik
Fen > Tıp > Biyokimya ve Moleküler Biyoloji
Fen > Tıp > Dermatoloji
Fen > Tıp > Acil Tıp
Fen > Tıp > Hematoloji
Fen > Tıp > Enfeksiyon Hastalıkları
Fen > Tıp > Tıbbi İnformatik
Fen > Tıp > Tıbbi Laboratuar Teknolojisi
Fen > Tıp > Nörolojik Bilimler
Fen > Tıp > Onkoloji
Fen > Tıp > Göz Hastalıkları
Fen > Tıp > Kulak, Burun, Boğaz
Fen > Tıp > Patoloji
Fen > Tıp > Romatoloji
Fen > Tıp > Spor Bilimleri
Fen > Tıp > Adli Tıp
Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Periferik Damar Hastalıkları
Fen > Tıp > Üroloji ve Nefroloji
Fen > Tıp > Kadın Hastalıkları ve Doğum
Fen > Tıp > Geriatri ve Gerontoloji
Fen > Tıp > Temel Sağlık Hizmetleri
Fen > Tıp > Alerji
Fen > Tıp > Odyoloji ve Konuşma-Dil Patolojisi
Fen > Tıp > Biyoteknoloji ve Uygulamalı Mikrobiyoloji
Fen > Tıp > Hücre Biyolojisi
Fen > Tıp > Klinik Nöroloji
Fen > Tıp > Yoğun Bakım, Tıp
Fen > Tıp > Tıbbi Etik
Fen > Tıp > Ortopedi
Fen > Tıp > Pediatri
Fen > Tıp > Solunum Sistemi
Fen > Tıp > Cerrahi
Fen > Temel Bilimler > Biyoloji
Fen > Tıp > Halk ve Çevre Sağlığı
Fen > Tıp > Sağlık Bilimleri ve Hizmetleri
Fen > Diş Hekimliği > Diş Hekimliği
Fen > Diş Hekimliği
Fen > Tıp > Anestezi
Fen > Tıp > İmmünoloji
Fen > Tıp > Mikrobiyoloji
Fen > Tıp > Fizyoloji
Fen > Tıp > Psikiyatri
Fen > Tıp > Rehabilitasyon
Fen > Tıp > Transplantasyon
Fen > Tıp > Tropik Tıp
Fen > Tıp > Tamamlayıcı ve Entegre Tıp
Fen > Tıp > Genel ve Dahili Tıp
Fen > Tıp > Gastroenteroloji ve Hepatoloji
Fen > Tıp > Endokrinoloji ve Metabolizma
Fen > Tıp > Kalp ve Kalp Damar Sistemi
Fen > Tıp > Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme

Cytoplasmic biomolecules of WNT/Beta-catenin signaling pathway

Öz:
Wnt/β-catenin signaling pathway, which is highly evolutionarily conserved from invertebrates to vertebrates, regulates apoptosis, adipogenesis, angiogenesis, synapse formation in adult tissues, and controls embryonic development in the embryo. Researches related to the signal pathway because of its probable role in the etiology of serious diseases such as cancer are quite increased. In the studies, for determining the role of Wnt/β-catenin signaling pathway in these diseases, are mostly investigated biomolecules such as β-catenin, Axin, Adenomatous Polyposis Coli (APC). In addition, these biomolecules are not only used in determining the mechanisms of diseases, but also used as a target for treatment. Thus, determination of the cytoplasmic reactions, which are the most important step of the Wnt/beta-catenin signaling pathway, and biomolecules of these reactions are very important for understanding of fully signaling mechanism. Therefore, discussion of biomolecules in the cytoplasm of target cells and identification of the entire mechanism of the signaling pathway were aimed in our review.
Anahtar Kelime:

Konular:
Fen > Tıp > Anatomi ve Morfoloji
Fen > Tıp > Androloji
Fen > Tıp > Biyofizik
Fen > Tıp > Biyokimya ve Moleküler Biyoloji
Fen > Tıp > Dermatoloji
Fen > Tıp > Acil Tıp
Fen > Tıp > Hematoloji
Fen > Tıp > Enfeksiyon Hastalıkları
Fen > Tıp > Tıbbi İnformatik
Fen > Tıp > Tıbbi Laboratuar Teknolojisi
Fen > Tıp > Nörolojik Bilimler
Fen > Tıp > Onkoloji
Fen > Tıp > Göz Hastalıkları
Fen > Tıp > Kulak, Burun, Boğaz
Fen > Tıp > Patoloji
Fen > Tıp > Romatoloji
Fen > Tıp > Spor Bilimleri
Fen > Tıp > Adli Tıp
Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Periferik Damar Hastalıkları
Fen > Tıp > Üroloji ve Nefroloji
Fen > Tıp > Kadın Hastalıkları ve Doğum
Fen > Tıp > Geriatri ve Gerontoloji
Fen > Tıp > Temel Sağlık Hizmetleri
Fen > Tıp > Alerji
Fen > Tıp > Odyoloji ve Konuşma-Dil Patolojisi
Fen > Tıp > Biyoteknoloji ve Uygulamalı Mikrobiyoloji
Fen > Tıp > Hücre Biyolojisi
Fen > Tıp > Klinik Nöroloji
Fen > Tıp > Yoğun Bakım, Tıp
Fen > Tıp > Tıbbi Etik
Fen > Tıp > Ortopedi
Fen > Tıp > Pediatri
Fen > Tıp > Solunum Sistemi
Fen > Tıp > Cerrahi
Fen > Temel Bilimler > Biyoloji
Fen > Tıp > Halk ve Çevre Sağlığı
Fen > Tıp > Sağlık Bilimleri ve Hizmetleri
Fen > Diş Hekimliği > Diş Hekimliği
Fen > Diş Hekimliği
Fen > Tıp > Anestezi
Fen > Tıp > İmmünoloji
Fen > Tıp > Mikrobiyoloji
Fen > Tıp > Fizyoloji
Fen > Tıp > Psikiyatri
Fen > Tıp > Rehabilitasyon
Fen > Tıp > Transplantasyon
Fen > Tıp > Tropik Tıp
Fen > Tıp > Tamamlayıcı ve Entegre Tıp
Fen > Tıp > Genel ve Dahili Tıp
Fen > Tıp > Gastroenteroloji ve Hepatoloji
Fen > Tıp > Endokrinoloji ve Metabolizma
Fen > Tıp > Kalp ve Kalp Damar Sistemi
Fen > Tıp > Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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APA DÖNMEZ H, DEMİREZEN S, BEKSAÇ M (2011). WNT/Beta-katenin sinyal yolunun sitoplazmik biyomolekülleri. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, 25(3), 189 - 199.
Chicago DÖNMEZ HANİFE GÜLER,DEMİREZEN Sayeste,BEKSAÇ Mehmet Sinan WNT/Beta-katenin sinyal yolunun sitoplazmik biyomolekülleri. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi 25, no.3 (2011): 189 - 199.
MLA DÖNMEZ HANİFE GÜLER,DEMİREZEN Sayeste,BEKSAÇ Mehmet Sinan WNT/Beta-katenin sinyal yolunun sitoplazmik biyomolekülleri. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, vol.25, no.3, 2011, ss.189 - 199.
AMA DÖNMEZ H,DEMİREZEN S,BEKSAÇ M WNT/Beta-katenin sinyal yolunun sitoplazmik biyomolekülleri. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi. 2011; 25(3): 189 - 199.
Vancouver DÖNMEZ H,DEMİREZEN S,BEKSAÇ M WNT/Beta-katenin sinyal yolunun sitoplazmik biyomolekülleri. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi. 2011; 25(3): 189 - 199.
IEEE DÖNMEZ H,DEMİREZEN S,BEKSAÇ M "WNT/Beta-katenin sinyal yolunun sitoplazmik biyomolekülleri." Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, 25, ss.189 - 199, 2011.