Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients

ARICIOĞLU, Aysel; Cumaoğlu, Ahmet; TAŞ, Nihal; kARAOĞLAN, bELGİN; ÖZHAN OKTAR, SUNA; ÖZDOĞAN, Vildan; Öztürk, Gökhan Tuna

Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients

Belgin KARAOĞLAN, (Gazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye)

Gökhan Tuna ÖZTÜRK, (Niğde Devlet Hastanesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Niğde, Türkiye)

Vildan ÖZDOĞAN, (Çaycuma Devlet Hastanesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Zonguldak, Türkiye)

Ahmet CUMAOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

SUNA ÖZHAN OKTAR, (Gazi Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye)

Nihal TAŞ, (Gazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye)

Aysel ARICIOĞLU (Gazi Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi

2 1

Yıl: 2011 Cilt: 57 Sayı: 3 Sayfa Aralığı: 114 - 118 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients

Öz:

Amaç: Nitrik oksit sentezinin endojen inhibitörü olan asimetrik dimetilargini nin (ADMA) plazma düzeyleri, artmış kardiyovasküler risk, endotelyal dis fonksiyon ve ateroskleroz ile ilişkilidir. Karotid arter intima-media kalınlığı (IMT), koroner arter hastalık gelişimi riski ile yakından ilişkilidir. Biz bu çalış mamızda romatoid artritli hastalarda plazma ADMA düzeylerini belirlemeyi ve bunun karotid IMT ile arasındaki ilişkiyi incelemeyi amaçladık. Gereç ve Yöntem: Araştırmamıza romatoid artrit tanısı konulan 18 Türk hasta(16 kadın, 2 erkek; yaş ortalamaları 49,44±8,88 yıl) ve 18 sağlıklı gönüllü (16 kadın, 2 erkek; yaş ortalamaları 46,28±4,97 yıl) dahil edildi. IMT ölçümü B-mode ultrasonografi ile değerlendirildi. Hasta ve sağlıklı gönüllülerin plazma ADMA düzeyleri ile her iki taraf karotid arter intima-media kalınlıkları ölçülerek iki gru bun ortalamaları karşılaştırıldı. Ayrıca romatoid artritli hastaların ADMA düzeyle rinin karotid arter intima-media kalınlıkları ile olan korelasyonu değerlendirildi.Bulgular: Plazma ADMA düzeyleri hasta grubunda kontrol grubuna göre anlamlı derecede yüksekti. Karotid arter IMT değerleri ise hasta grubunda kontrol grubu na göre yüksek olmasına rağmen bu fark istatistiksel olarak anlamlı değildi. Hasta grubunda ADMA düzeyleri ile karotid IMT değerleri arasında korelasyon yoktu.Sonuç: Bizim sonuçlarımız plazma ADMA düzeylerinin romatoid artritli hasta larda daha yüksek olduğunu göstermiştir. ADMA düzeyleri ile karotid IMT değerleri arasında korelasyon gözlenmemesine rağmen, ADMA seviyeleri endo telyal disfonksiyonun değerlendirilmesinde kullanılabilir. Türk Fiz Tıp Rehab Derg 2011;57:114-8.

Anahtar Kelime:

Konular: Rehabilitasyon

Romatoid artritli hastalarda ADMA düzeyleri ile karotid arter intima-media kalınlığı arasındaki ilişkinin saptanması

Öz:

Objective: Plasma asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, is related to increased cardiovascular risks, endothelial dysfunction and atherosclerosis. Carotid arteryintima-media thickness (IMT) is closely related to the risk of coronary artery disease. We aimed to investigate plasma ADMA levels and itsrelation to carotid IMT in patients with rheumatoid arthritis (RA). Materials and Methods: Eighteen Turkish patients with RA (16 females, mean age: 49.44±8.88 years) and 18 age- and gender-matched healthy controls (16 females, mean age: 46.28±4.97 years) were included in the study. Measurement of IMT was done by B-mode ultrasound. Plasma ADMA levels and carotid IMT of both sides were measured in all patients and healthycontrols, and the means of the two groups were compared. The correlation between ADMA levels and carotid IMT was assessed in patients with RA. Results: Plasma ADMA levels were significantly higher in patientscompared to healthy controls. Although the carotid IMT values wererelatively higher in the patient group than in the control group, thedifference was not statistically significant. There was no significantcorrelation between ADMA levels and carotid IMT values. Conclusion: Our findings support the notion that plasma ADMA levels are elevated in patients with RA. Despite lack of correlation between ADMA levels and IMT in our study, ADMA levels can be used to evaluateendothelial dysfunction. Turk J Phys Med Re hab 2011;57:114-8.

Anahtar Kelime:

Konular: Rehabilitasyon

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	kARAOĞLAN b, Öztürk G, ÖZDOĞAN V, Cumaoğlu A, ÖZHAN OKTAR S, TAŞ N, ARICIOĞLU A (2011). Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. , 114 - 118.
Chicago	kARAOĞLAN bELGİN,Öztürk Gökhan Tuna,ÖZDOĞAN Vildan,Cumaoğlu Ahmet,ÖZHAN OKTAR SUNA,TAŞ Nihal,ARICIOĞLU Aysel Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. (2011): 114 - 118.
MLA	kARAOĞLAN bELGİN,Öztürk Gökhan Tuna,ÖZDOĞAN Vildan,Cumaoğlu Ahmet,ÖZHAN OKTAR SUNA,TAŞ Nihal,ARICIOĞLU Aysel Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. , 2011, ss.114 - 118.
AMA	kARAOĞLAN b,Öztürk G,ÖZDOĞAN V,Cumaoğlu A,ÖZHAN OKTAR S,TAŞ N,ARICIOĞLU A Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. . 2011; 114 - 118.
Vancouver	kARAOĞLAN b,Öztürk G,ÖZDOĞAN V,Cumaoğlu A,ÖZHAN OKTAR S,TAŞ N,ARICIOĞLU A Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. . 2011; 114 - 118.
IEEE	kARAOĞLAN b,Öztürk G,ÖZDOĞAN V,Cumaoğlu A,ÖZHAN OKTAR S,TAŞ N,ARICIOĞLU A "Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients." , ss.114 - 118, 2011.
ISNAD	kARAOĞLAN, bELGİN vd. "Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients". (2011), 114-118.

APA	kARAOĞLAN b, Öztürk G, ÖZDOĞAN V, Cumaoğlu A, ÖZHAN OKTAR S, TAŞ N, ARICIOĞLU A (2011). Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 57(3), 114 - 118.
Chicago	kARAOĞLAN bELGİN,Öztürk Gökhan Tuna,ÖZDOĞAN Vildan,Cumaoğlu Ahmet,ÖZHAN OKTAR SUNA,TAŞ Nihal,ARICIOĞLU Aysel Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 57, no.3 (2011): 114 - 118.
MLA	kARAOĞLAN bELGİN,Öztürk Gökhan Tuna,ÖZDOĞAN Vildan,Cumaoğlu Ahmet,ÖZHAN OKTAR SUNA,TAŞ Nihal,ARICIOĞLU Aysel Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, vol.57, no.3, 2011, ss.114 - 118.
AMA	kARAOĞLAN b,Öztürk G,ÖZDOĞAN V,Cumaoğlu A,ÖZHAN OKTAR S,TAŞ N,ARICIOĞLU A Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2011; 57(3): 114 - 118.
Vancouver	kARAOĞLAN b,Öztürk G,ÖZDOĞAN V,Cumaoğlu A,ÖZHAN OKTAR S,TAŞ N,ARICIOĞLU A Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2011; 57(3): 114 - 118.
IEEE	kARAOĞLAN b,Öztürk G,ÖZDOĞAN V,Cumaoğlu A,ÖZHAN OKTAR S,TAŞ N,ARICIOĞLU A "Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients." Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 57, ss.114 - 118, 2011.
ISNAD	kARAOĞLAN, bELGİN vd. "Investigation of the correlation between ADMA levels and carotid artery intima-media thickness in rheumatoid arthritis patients". Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 57/3 (2011), 114-118.