Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis

ERTEKİN, Ali; Cebi, Aysegul; Çelikezen, Fatih Çağlar

Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis

Ayşegül ÇEBİ, (Giresun Üniversitesi, Sağlık Bilimleri Fakültesi, Giresun, Türkiye)

Fatih Çağlar ÇELİKEZEN, (Bitlis Eren Üniversitesi Tıp Fakültesi, Bilim ve Sanat, Bitlis, Türkiye)

Ali ERTEKİN (Ondokuz Mayıs Üniversitesi, Veteriner Fakültesi, Samsun, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

3 0

Yıl: 2012 Cilt: 18 Sayı: 2 Sayfa Aralığı: 309 - 312 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis

Öz:

Koenzim Q10 (CoQ10) mitokondrial matrikste bulunan antioksidan bir elektron taşıyıcısıdır.Bu çalışmanın amacı bleomisinuygulanarak oluşturulmuş akciğer fibrozisinde CoQ10’ nin Fe, Cu, Zn ve Mn düzeyleri üzerine koruyucu etkisini araştırmaktı. OtuzWistar albino ırkı rat yalnız bleomisin uygulanan grup, bleomisin + CoQ10 uygulanan grup, ve yalnız serum fizyolojik uygulanan grup(kontrol grubu) olmak üzere 3 gruba ayrıldı. Bleomisin grubuna bleomisin hidroklorid 7.5 mg/kg canlı ağırlık oranında intratrakealolarak tek doz şeklinde uygulandı. Bleomisin + CoQ10 grubuna da bleomisine ilave olarak haftada iki kez CoQ10 uygulandı. Kontrolgrubuna ise yalnız serum fizyolojik uygulandı. Bleomisin uygulamasından 14 gün sonra ratlara ötenazi uygulandı. Serumlarında Fe, Cu,Zn ve Mn düzeyleri saptandı. Fe, Cu, Zn ve Mn düzeylerinin belirlenmesinde atomik absorbsiyon spektrofotometresi kullanıldı. Eldeettiğimiz veriler, bleomisinin antioksidan sistemde önemi olan Fe, Cu, Zn ve Mn dengesini bozduğunu ve CoQ10’ in akciğer fibrozisindeağır metal ve iz element dengesizliğini yeniden değiştirdiğini düşündürmektedir.

Anahtar Kelime: kan kimyası demir mangan akciğerler çinko eser elementler sıçan fibroz bakır ubikuinon

Konular: Veterinerlik

Koenzim q10’ nin bleomisinin teşvik ettiği akciğer fibrozisli ratların serumlarındaki bazı iz elementlerin seviyelerine etkisi

Öz:

Coenzyme Q10 (CoQ10) is an antioxidant and an electron carrier in the mitochondrial matrix. The aim of this study was to study theprotective effect of CoQ10 on the levels of Fe, Cu, Zn and Mn in serum with bleomycin induced pulmonary fibrosis in rats. Thirty Wistaralbino rats were randomly divided into three groups: bleomycin alone, bleomycin + CoQ10, and physiological saline alone (controlgroup). The bleomycin group was given 7.5 mg/kg body weight (single dose) bleomycin hydrochloride intratracheally. The bleomycin+ CoQ10 group was also instilled with bleomycin hydrochloride but received administrations of CoQ10 twice a week. The controlgroup was treated with physiological saline alone. Animals were euthanized 14 d after intratracheal instillation of bleomycin. Fe, Cu,Zn and Mn were measured in the serum of rats. Atomic absorption spectroscopy was used to measure the Fe, Cu, Zn and Mn levels.Our data may suggest that bleomycin impairs the equilibrium of Fe, Cu, Zn and Mn which are important in the antioxidant system andCoQ10 tends to rechange the imbalance of some trace elements in pulmonary fibrosis.

Anahtar Kelime: zinc trace elements rats fibrosis copper ubiquinones blood chemistry iron manganese lungs

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Cebi A, Çelikezen F, ERTEKİN A (2012). Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. , 309 - 312.
Chicago	Cebi Aysegul,Çelikezen Fatih Çağlar,ERTEKİN Ali Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. (2012): 309 - 312.
MLA	Cebi Aysegul,Çelikezen Fatih Çağlar,ERTEKİN Ali Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. , 2012, ss.309 - 312.
AMA	Cebi A,Çelikezen F,ERTEKİN A Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. . 2012; 309 - 312.
Vancouver	Cebi A,Çelikezen F,ERTEKİN A Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. . 2012; 309 - 312.
IEEE	Cebi A,Çelikezen F,ERTEKİN A "Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis." , ss.309 - 312, 2012.
ISNAD	Cebi, Aysegul vd. "Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis". (2012), 309-312.

APA	Cebi A, Çelikezen F, ERTEKİN A (2012). Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 18(2), 309 - 312.
Chicago	Cebi Aysegul,Çelikezen Fatih Çağlar,ERTEKİN Ali Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 18, no.2 (2012): 309 - 312.
MLA	Cebi Aysegul,Çelikezen Fatih Çağlar,ERTEKİN Ali Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.18, no.2, 2012, ss.309 - 312.
AMA	Cebi A,Çelikezen F,ERTEKİN A Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2012; 18(2): 309 - 312.
Vancouver	Cebi A,Çelikezen F,ERTEKİN A Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2012; 18(2): 309 - 312.
IEEE	Cebi A,Çelikezen F,ERTEKİN A "Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 18, ss.309 - 312, 2012.
ISNAD	Cebi, Aysegul vd. "Effects of coenzyme q10 on the levels of some trace elements in serum of rats with bleomycin ınduced pulmonary fibrosis". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 18/2 (2012), 309-312.