Yıl: 2012 Cilt: 36 Sayı: 3 Sayfa Aralığı: 411 - 426 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents

Öz:
2-Morpholine-4ylethyl-3H -1,2,4-triazole-3-ones (2a, 2b) were obtained from the condensation between the corresponding ethoxycarbonylhydrazones and 2-morpholinoethanamine. 2a was converted to acetohydrazide (4) via the formation of an ester derivative (3). Treatment of 2a and 2b with several aryl sulfonyl chlorides afforded the corresponding 2-arylsulfonyl-1,2,4-triazole-3-ones (5a-c and 6). The reaction of hydrazide (4) with benzyl iso- and benzyl isothiocyanate produced the corresponding carboxamide (8a) and carbothioamide (8b). The basic treatment of 8b yielded 5-mercapto-4H-1,2,4-triazol-3- yl)methyl]-2,4-dihydro-3H -1,2,4-triazol-3-one (10). The synthesis of 1,3-thiazol-2(3H) -ylidene-1,2,4-triazol- 1-ylacetohydrazide (11) and 1,3-oxazole-2(3H) -ylidene-1,2,4-triazole-1-yl)acetohydrazide (9) derivatives was performed from the reaction of 8a and 8b with substituted phenacyl bromides. All the newly synthesized compounds were screened for their antimicrobial activities and some of them were found to possess good or moderate antimicrobial activity.
Anahtar Kelime:

Konular: Mühendislik, Kimya
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ŞAHİN D, BAYRAK H, DEMİRBAŞ A, DEMİRBAŞ N, Alpay Karaoğlu Ş (2012). Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. , 411 - 426.
Chicago ŞAHİN Deniz,BAYRAK Hacer,DEMİRBAŞ Ahmet,DEMİRBAŞ NESLİHAN,Alpay Karaoğlu Şengül Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. (2012): 411 - 426.
MLA ŞAHİN Deniz,BAYRAK Hacer,DEMİRBAŞ Ahmet,DEMİRBAŞ NESLİHAN,Alpay Karaoğlu Şengül Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. , 2012, ss.411 - 426.
AMA ŞAHİN D,BAYRAK H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. . 2012; 411 - 426.
Vancouver ŞAHİN D,BAYRAK H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. . 2012; 411 - 426.
IEEE ŞAHİN D,BAYRAK H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş "Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents." , ss.411 - 426, 2012.
ISNAD ŞAHİN, Deniz vd. "Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents". (2012), 411-426.
APA ŞAHİN D, BAYRAK H, DEMİRBAŞ A, DEMİRBAŞ N, Alpay Karaoğlu Ş (2012). Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. Turkish Journal of Chemistry, 36(3), 411 - 426.
Chicago ŞAHİN Deniz,BAYRAK Hacer,DEMİRBAŞ Ahmet,DEMİRBAŞ NESLİHAN,Alpay Karaoğlu Şengül Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. Turkish Journal of Chemistry 36, no.3 (2012): 411 - 426.
MLA ŞAHİN Deniz,BAYRAK Hacer,DEMİRBAŞ Ahmet,DEMİRBAŞ NESLİHAN,Alpay Karaoğlu Şengül Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. Turkish Journal of Chemistry, vol.36, no.3, 2012, ss.411 - 426.
AMA ŞAHİN D,BAYRAK H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. Turkish Journal of Chemistry. 2012; 36(3): 411 - 426.
Vancouver ŞAHİN D,BAYRAK H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents. Turkish Journal of Chemistry. 2012; 36(3): 411 - 426.
IEEE ŞAHİN D,BAYRAK H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş "Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents." Turkish Journal of Chemistry, 36, ss.411 - 426, 2012.
ISNAD ŞAHİN, Deniz vd. "Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents". Turkish Journal of Chemistry 36/3 (2012), 411-426.