The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study

KUMANDAS, ALI; Pekcan, Zeynep; Elma, Ertuğrul; KÜRÜM, BARIS; KARSLI, BIRKAN

The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study

BARIŞ KÜRÜM, (Kırıkkale Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Kırıkkale Türkiye)

Zeynep PEKCAN, (Kırıkkale Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Kırıkkale Türkiye)

Birkan KARSLI, (Kırıkkale Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Kırıkkale Türkiye)

Ali KUMANDAŞ, (Kırıkkale Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Kırıkkale Türkiye)

Ertuğrul ELMA (Kırıkkale Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Kırıkkale Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2012 Cilt: 18 Sayı: 4 Sayfa Aralığı: 671 - 676 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study

Öz:

Günümüzde ağrının kontrol edilmesinin gerekliliği net olarak ortaya konulmuştur. Bu amaçla farklı ilaç grupları kullanılmaktadır, şu an için en yaygın kullanılan ilaç gruplarından birisi de steroid olmayan yangı önleyici ilaçlardır (NSAIDs). Prostaglandin-endoperoxide sentetaz ya da daha sık kullanılan adı ile siklooksijenaz enzimleri (COX) prostoglandin sentezinde anahtar rolü olan enzimlerdir. COX enzimleri üç alt grubu olan bir enzim grubudur ve her alt grup farklı yangı mediatörlerini baskılarlar. Bu enzimlerin farklı fonksiyonları vardır ve bazıları fizyolojik fonksiyonların devamı için gereklidir. Dolayısı ile kullanılacak NSAID ilacın kimi enzim gruplarını baskılarken kimi enzim gruplarının fonksiyonlarında değişim oluşturmaması istenir. Bu enzim gruplarından COX-1 olarak isimlendirilenler gastrointestinal sistem fonksiyonları ve mukozası ile, COX-2 grubu ise yangı ve ağrı ile ilişkilidir. İlaçların çoğu gibi NSAID ilaçların da bilinen yan etkilerine ilaveten olası yan etkileri de vardır. NSAID ilaçlarla ilgili yapılan çeşitli araştırmalarda, hem seçici etkisi olmayan geleneksel NSAID ilaçların hem de spesifik COX-2 inhibitörü ilaçların kemik iyileşmesi üzerinde inhibe edici etkileri rapor edilmiştir. Bu çalışmada 24 adet, Wistar ırkı, erişkin, erkek rat kullanılarak ketoprofen ve meloksikamın kırık iyileşmesi üzerine olan etkileri klinik gözlemler ve Dual Energy X-Ray Absorptiometry (DEXA) ölçümleri ile ortaya konulmaya çalışılmıştır. Elde edilen veriler meloksikamın kırık iyileşmesini bir ölçüde inhibe edebildiğini göstermektedir.

Anahtar Kelime: kemik teknikler kemik kırıkları modeller metodoloji sıçan ketoprofen ağrı (tıp) steroit olmayan antienflamatuar ajanlar iyileşme

Konular: Veterinerlik

Ketoprofen ve meloksikam’ın kemik iyileşmesi üzerine etkilerinin rat modelinde DEXA ölçümleri ile değerlendirilmesi

Öz:

Pain control is a common clinical approach in trauma and postoperative care especially complicated orthopedic surgeries to ease the deleterious effects of pain. Various kinds of pain killers have been used, and nowadays nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs for pain control purposes. Prostaglandin-endoperoxide synthetase, also commonly called cyclooxygenase (COX), is one of the key enzymes in prostaglandin bio-synthesis. The COX enzymes have subgroups of enzymes, each of which suppresses different inflammatory mediators. These enzymes are involved in different functions, some of which are essential for continuity of physiological processes. Thus, NSAIDs are expected not to cause any change of functions of some enzymes while suppressing others. Among the COX enzymes, COX-1 is associated with gastrointestinal system functions and gastrointestinal mucosa while COX-2 is associated with inflammation and pain. Like most drugs, NSAIDs have known and possible side effects. In various studies related to NSAIDs, inhibitory effects of conventional NSAIDs with non-selective effects and specific COX-2 inhibitors on bone healing have been reported. In this study, the effects of ketoprofen and meloxicam on bone fracture healing induced in 24 adult male Wistar rats was studied by Dual Energy X-Ray Absorptiometry (DEXA). The results indicates that meloxicam inhibits the fracture healing to some degree.

Anahtar Kelime: methodology rats ketoprofen pain non-steroidal antiinflammatory agents healing bones techniques bone fractures models

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KÜRÜM B, Pekcan Z, KARSLI B, KUMANDAS A, Elma E (2012). The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. , 671 - 676.
Chicago	KÜRÜM BARIS,Pekcan Zeynep,KARSLI BIRKAN,KUMANDAS ALI,Elma Ertuğrul The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. (2012): 671 - 676.
MLA	KÜRÜM BARIS,Pekcan Zeynep,KARSLI BIRKAN,KUMANDAS ALI,Elma Ertuğrul The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. , 2012, ss.671 - 676.
AMA	KÜRÜM B,Pekcan Z,KARSLI B,KUMANDAS A,Elma E The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. . 2012; 671 - 676.
Vancouver	KÜRÜM B,Pekcan Z,KARSLI B,KUMANDAS A,Elma E The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. . 2012; 671 - 676.
IEEE	KÜRÜM B,Pekcan Z,KARSLI B,KUMANDAS A,Elma E "The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study." , ss.671 - 676, 2012.
ISNAD	KÜRÜM, BARIS vd. "The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study". (2012), 671-676.

APA	KÜRÜM B, Pekcan Z, KARSLI B, KUMANDAS A, Elma E (2012). The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 18(4), 671 - 676.
Chicago	KÜRÜM BARIS,Pekcan Zeynep,KARSLI BIRKAN,KUMANDAS ALI,Elma Ertuğrul The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 18, no.4 (2012): 671 - 676.
MLA	KÜRÜM BARIS,Pekcan Zeynep,KARSLI BIRKAN,KUMANDAS ALI,Elma Ertuğrul The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.18, no.4, 2012, ss.671 - 676.
AMA	KÜRÜM B,Pekcan Z,KARSLI B,KUMANDAS A,Elma E The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2012; 18(4): 671 - 676.
Vancouver	KÜRÜM B,Pekcan Z,KARSLI B,KUMANDAS A,Elma E The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2012; 18(4): 671 - 676.
IEEE	KÜRÜM B,Pekcan Z,KARSLI B,KUMANDAS A,Elma E "The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 18, ss.671 - 676, 2012.
ISNAD	KÜRÜM, BARIS vd. "The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 18/4 (2012), 671-676.