Oral findings in children with celiac disease

KILIÇ, NİHAT; sümbüllü, muhammed akif; Selimoglu, Mukadder Ayse; TOSUN, Mahya Sultan; KARA, MUSTAFA; ERTEKİN, VİLDAN

Oral findings in children with celiac disease

Vildan ERTEKİN, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Pediatrik Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Muhammed Akif SÜMBÜLLÜ, (Atatürk Üniversitesi, Diş Hekimliği Fakültesi, Oral Diagnoz ve Radyoloji Anabilim Dalı, Erzurum, Türkiye)

Mahya Sultan TOSUN, (Atatürk Üniversitesi, Tıp Fakültesi, Pediatrik Gastroenteroloji, Hepatoloji ve Beslenme Anabilim, Dalı, Erzurum, Türkiye)

Mukadder Ayşe SELİMOĞLU, (İnönü Üniversitesi, Tıp Fakültesi, Pediatri Gastroenteroloji Anabilim Dalı, Malatya, Türkiye)

Mustafa KARA, (Atatürk Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Erzurum, Türkiye)

Nihat KILIÇ (Atatürk Üniversitesi, Diş Hekimliği Fakültesi, Ortodonti Anabilim Dalı, Erzurum, Türkiye)

Turkish Journal of Medical Sciences

0 0

Yıl: 2012 Cilt: 42 Sayı: 4 Sayfa Aralığı: 613 - 617 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Oral findings in children with celiac disease

Öz:

Amaç: Çölyak hastalığı (ÇH) olan Türk çocuklarında dental enamel defekt (DED)’ler, tekrarlayan aftöz stomatit (TAS), diş kaybı ve ağız kuruluğu olup olmadığını araştırmak ve bunu yaş ve cinsiyete göre karşılaştırmak. Yöntem ve gereç: 81 çölyak hastası (ortalama yaş 8,7 ± 3,7 yıl, yaş aralığı 2,5-17 yıl) ve 20 sağlıklı kontrol grubunun ağız boşluğu incelendi. Enamel defektler, diş kaybı, aftöz stomatit ve ağız kuruluğu tespit edildi. Bulgular: 43 (% 53,1) çölyak hastasına karşılık 5 (% 25) kontrol grubunda enamel defekt vardı. Çölyak hastalarında enamel defekt daha fazla gözlendi (P = 0,025). TAS ile ilgili 39 (% 48,1) hastada ve 1 (% 5) kontrol grubunda aft öz ülserler vardı (P = 0,0001). 11 (% 13,6) hastada diş kaybı ve 47 (% 58) hastada ağız kuruluğu tespit edildi. ÇH’larında ağız kuruluğu kontrol grubuna göre anlamlı derecede daha yüksekti (P = 0,008). Bu çalışmada DED, TAS ve ağız kuruluğu kontrol grubuna göre çölyak hastalarında daha yüksek bulundu. Sonuç: Spesifik DED, TAS ve ağız kuruluğu olan çocukların erkenden tanınıp pediatristlere yönlendirilmesi daha erken ÇH tanısının konulmasına yardım edebilir.

Anahtar Kelime: Diş minesi Tekrarlama Çölyak hastalığı Yaş dağılımı Çocuk Stomatit, aftöz Cinsiyet dağılımı

Konular: Cerrahi

Çölyak hastalığı olan çocuklarda oral bulgular

Öz:

Aim: To investigate whether Turkish children with celiac disease (CD) show dental enamel defects (DEDs), recurrent aphthous stomatitis (RAS), teeth missing, and xerostomia, and to compare the results with age- and sex-matched healthy children. Materials and methods: The oral cavity was explored in 81 patients with CD (mean age 8.7 ± 3.7 years; age range 2.5 to 17 years) and in 20 healthy controls. Enamel defects, teeth missing, RAS, and xerostomia were established. Results: Forty-three (53.1%) celiac patients and 5 (25%) control subjects had enamel defects. Enamel defects occurred more frequently in patients (P = 0.025) compared to controls. Regarding RAS, 39 (48.1%) patients and 1 (5%) control had aphthous ulcers (P = 0.0001). Teeth missing and xerostomia were detected in 11 (13.6%) and 47 (58%) patients, respectively. Patients with xerostomia were signifi cantly greater in number compared to healthy children (P = 0.008). In the present study, the prevalence of DEDs, RAS, and xerostomia was greater in celiac patients than in healthy controls. Conclusion: Early recognition of children with specific DEDs, RAS, and xerostomia and thus their referral to pediatricians might help in early diagnosis of CD.

Anahtar Kelime: Age Distribution Child Stomatitis, Aphthous Sex Distribution Dental Enamel Recurrence Celiac Disease

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Pastore L, Carroccio A, Compilato D, Panzarella V, Serpico R, Lo Muzio L. Oral manifestations of celiac disease. J Clin Gastroenterol 2008; 42: 224-32.
2. Da Silva PC, De Almeida PV, Machado MÂN, De Lima AAS, Grégio AMT, Trevilatto PC et al. Oral manifestations of celiac disease. A case report and review of the literature. Med Oral Patol Oral Cir Bucal 2008; 13: 559-62.
3. Ortega Páez E, Junco Lafuente P, Baca García P, Maldonado Lozano J, Llodra Calvo JC. Prevalence of dental enamel defects in celiac patients with deciduous dentition: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 74-8.
4. Campisi G, Di Liberto C, Iacono G, Compilato D, Di Prima L, Calvino F et al. Oral pathology in untreated coeliac [corrected] disease. Aliment Pharmacol Th er 2007; 26: 1529-36.
5. Wierink CD, Van Diermen DE, Aartman IHA, Heymans HSA. Dental enamel defects in children with coeliac disease. Int J Paediatr Dent 2007; 17: 163-8.
6. Procaccini M, Campisi G, Bufo P, Compilato D, Massaccesi C, Catassi C et al. Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region. Head Face Med 2007; 3: 25.
7. Ertekin V, Selimoğlu MA, Kardaş F, Aktaş E. Prevalence of celiac disease in Turkish children. J Clin Gastroenterol 2005; 39: 689-91.
8. Sedghizadeh PP, Shuler CF, Allen CM, Beck FM, Kalmar JR. Celiac disease and recurrent aphthous stomatitis: a report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 474-8.
9. Aine L, Maki M, Collin P, Keyrilainen O: Dental enamel defects in celiac disease. J Oral Pathol Med 1990; 19: 241-45.
10. Jensen JL, Barkvoll P. Clinical implications of dry mouth: oral mucosal diseases. Ann New York Acad Sci. 1998; 842: 156-62.
11. Campisi G, Di Liberto C, Carroccio A, Compilato D, Iacono G, Procaccini M, et al. Coeliac disease: oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Dig Liver Dis 2008; 40: 104-7.
12. Aine L. Dental enamel defects and dental maturity in children and adolescents with coeliac disease. Proc Finn Dent Soc 1986; 82: 1-71.
13. Cheng J, Malahias T, Brar P, Minaya MT, Green PHR. The association between celiac disease, dental enamel defects, and aphthous ulcers in a United States cohort. J Clin Gastroenterol 2010; 44: 191-94.
14. Mäki M, Aine L, Lipsanen V, Koskimies S. Dental enamel defects in first-degree relatives of coeliac disease patients. Lancet 1991; 337: 763-4.
15. Aguirre JM, Rodríguez R, Oribe D, Vitoria JC. Dental enamel defects in celiac patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 84: 646-50.
16. Seyhan M, Erdem T, Ertekin V, Selimoğlu MA. The mucocutaneous manifestations associated with celiac disease in childhood and adolescence. Pediatr Dermatol 2007; 24: 28- 33.
17. Lenander-Lumikari M, Ihalin R, Lähteenoja H. Changes in whole saliva in patients with coeliac disease. Arch Oral Biol 2000; 45: 347-54.
18. Lähteenoja H, Toivanen A, Viander M, Mäki M, Irjala K, Räihä I et al. Oral mucosal changes in coeliac patients on a glutenfree diet. Eur J Oral Sci 1998; 106: 899-906.

APA	ERTEKİN V, sümbüllü m, TOSUN M, Selimoglu M, KARA M, KILIÇ N (2012). Oral findings in children with celiac disease. , 613 - 617.
Chicago	ERTEKİN VİLDAN,sümbüllü muhammed akif,TOSUN Mahya Sultan,Selimoglu Mukadder Ayse,KARA MUSTAFA,KILIÇ NİHAT Oral findings in children with celiac disease. (2012): 613 - 617.
MLA	ERTEKİN VİLDAN,sümbüllü muhammed akif,TOSUN Mahya Sultan,Selimoglu Mukadder Ayse,KARA MUSTAFA,KILIÇ NİHAT Oral findings in children with celiac disease. , 2012, ss.613 - 617.
AMA	ERTEKİN V,sümbüllü m,TOSUN M,Selimoglu M,KARA M,KILIÇ N Oral findings in children with celiac disease. . 2012; 613 - 617.
Vancouver	ERTEKİN V,sümbüllü m,TOSUN M,Selimoglu M,KARA M,KILIÇ N Oral findings in children with celiac disease. . 2012; 613 - 617.
IEEE	ERTEKİN V,sümbüllü m,TOSUN M,Selimoglu M,KARA M,KILIÇ N "Oral findings in children with celiac disease." , ss.613 - 617, 2012.
ISNAD	ERTEKİN, VİLDAN vd. "Oral findings in children with celiac disease". (2012), 613-617.

APA	ERTEKİN V, sümbüllü m, TOSUN M, Selimoglu M, KARA M, KILIÇ N (2012). Oral findings in children with celiac disease. Turkish Journal of Medical Sciences, 42(4), 613 - 617.
Chicago	ERTEKİN VİLDAN,sümbüllü muhammed akif,TOSUN Mahya Sultan,Selimoglu Mukadder Ayse,KARA MUSTAFA,KILIÇ NİHAT Oral findings in children with celiac disease. Turkish Journal of Medical Sciences 42, no.4 (2012): 613 - 617.
MLA	ERTEKİN VİLDAN,sümbüllü muhammed akif,TOSUN Mahya Sultan,Selimoglu Mukadder Ayse,KARA MUSTAFA,KILIÇ NİHAT Oral findings in children with celiac disease. Turkish Journal of Medical Sciences, vol.42, no.4, 2012, ss.613 - 617.
AMA	ERTEKİN V,sümbüllü m,TOSUN M,Selimoglu M,KARA M,KILIÇ N Oral findings in children with celiac disease. Turkish Journal of Medical Sciences. 2012; 42(4): 613 - 617.
Vancouver	ERTEKİN V,sümbüllü m,TOSUN M,Selimoglu M,KARA M,KILIÇ N Oral findings in children with celiac disease. Turkish Journal of Medical Sciences. 2012; 42(4): 613 - 617.
IEEE	ERTEKİN V,sümbüllü m,TOSUN M,Selimoglu M,KARA M,KILIÇ N "Oral findings in children with celiac disease." Turkish Journal of Medical Sciences, 42, ss.613 - 617, 2012.
ISNAD	ERTEKİN, VİLDAN vd. "Oral findings in children with celiac disease". Turkish Journal of Medical Sciences 42/4 (2012), 613-617.