The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride

BAYRAM, İrfan; özbek, hanefi; Erten, Remzi; BAYRAM, YASEMIN; bulut, gülay

The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride

İrfan BAYRAM, (Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Van, Türkiye)

Remzi ERTEN, (Siirt Kadın Doğum ve Çocuk Hastalıkları Hastanesi, Siirt, Türkiye)

Yasemin BAYRAM, (Van Eğitim ve Araştırma Hastanesi, Mikrobiyoloji Bölümü, Van, Türkiye)

Gülay BULUT, (Van Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Patoloji Anabilim Dalı, Van, Türkiye)

Hanefi ÖZBEK (Sağlık Bakanlığı, İlaç ve Eczacılık Genel Müdürlüğü Ankara, Türkiye)

Turkish Journal of Gastroenterology

2 0

Yıl: 2011 Cilt: 22 Sayı: 6 Sayfa Aralığı: 594 - 601 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride

Öz:

Amaç: Vitis vinifera L. bitkisinde bulunan dihydromyrecenol ve geranyl formate’in sıçanlarda karbon tetraklorür ile oluşturulmış akut karaciğer hasarı modelinde hepatoprotektif etkilerinin araştırılması amaçlandı. Yöntem: Çalışmada, Sprague-Dawley cinsi 54 adet sıçan kullanıldı. Dokuz çalışma grubu oluşturuldu (n=6) ve yedi günlük çalışma sonrası sıçanlar sakrifiye edildi. Dihydromyrecenol ve geranyl formate'in akut karaciğer hasarı üzerindeki etkileri çalışma gruplarının vücut ağırlığı değişimleri, serum alanin aminotranseraz ve asparat aminotranseraz seviyeleri ve karaciğerdeki histopatolojik değişiklikler karşılaştırmalı olarak de- ğerlendirildi. Bulgular: Çalışmada karbon tetraklorür'ün etkisine bağlı artan balon dejenerasyonu ve apoptotik hücre sayısının; dihydromyrecenol ile anlamlı şekilde azaldıgığı ve geranyl formate'ın düşük dozları ile kısmen azaldığı ancak geranyl formate'ın yüksek dozu ile azalmadığı görüldü. Ayrıca alanin aminotranseraz ve asparat aminotranserazseviyelerindeki değişiklikler de bu bulgular ile uyumluluk gösterdi. Sonuç: Karbon tetraklorür ile oluşturulan deneysel akut karaciğer hasarında, dihydromyrecenol'un hepatoprotektif etkisinin olduğu ve geranyl formate'ın ise düşük dozlarda kısmen hepatoprotektif etkisinin olduğu ancak yüksek dozlarda hepatoprotektif etkisinin olmadığı söylenebilir.

Anahtar Kelime:

Konular: Cerrahi

Dihydromyrcenol ve geranyl formate’in sıçanlarda karbon tetraklorür ile oluşturulmuş akut karaciğer hasarı modelinde hepatoprotektif etkileri

Öz:

Background/aims: We aimed to investigate the hepatoprotective effects of dihydromyrcenol and geranyl formate extracted from the Vitis vinifera L. plant in a rat model of acute hepatic injury induced by carbon tetrachloride. Methods: The study was performed on 54 Sprague-Dawley male rats. The animals were divided into 9 study groups with 6 rats in each. At the end of the 7-day study period, the animals were sacrificed. The effects of dihydromyrcenol and geranyl formate on hepatic injury were evaluated based on the comparisons of the changes in the weight, serum levels of alanine aminotransferase and aspartate aminotransferase, and histopathological changes in the liver. Results: Dihydromyrcenol significantly reduced the carbon tetrachloride-associated ballooning degeneration and apoptotic cell counts; this reduction was moderate with low doses of geranyl formate, while no reductions were observed with high doses of geranyl formate. The changes in the alanine aminotransferase and aspartate aminotransferase levels were in accordance with these findings. Conclusions: It can be concluded that in an experimental model of acute hepatic injury induced by carbon tetrachloride, dihydromyrcenol presents a hepatoprotective effect, while geranyl formate presents partial hepatoprotective effects at low doses and no hepatoprotective effects at high doses.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BAYRAM İ, Erten R, BAYRAM Y, bulut g, özbek h (2011). The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. , 594 - 601.
Chicago	BAYRAM İrfan,Erten Remzi,BAYRAM YASEMIN,bulut gülay,özbek hanefi The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. (2011): 594 - 601.
MLA	BAYRAM İrfan,Erten Remzi,BAYRAM YASEMIN,bulut gülay,özbek hanefi The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. , 2011, ss.594 - 601.
AMA	BAYRAM İ,Erten R,BAYRAM Y,bulut g,özbek h The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. . 2011; 594 - 601.
Vancouver	BAYRAM İ,Erten R,BAYRAM Y,bulut g,özbek h The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. . 2011; 594 - 601.
IEEE	BAYRAM İ,Erten R,BAYRAM Y,bulut g,özbek h "The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride." , ss.594 - 601, 2011.
ISNAD	BAYRAM, İrfan vd. "The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride". (2011), 594-601.

APA	BAYRAM İ, Erten R, BAYRAM Y, bulut g, özbek h (2011). The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. Turkish Journal of Gastroenterology, 22(6), 594 - 601.
Chicago	BAYRAM İrfan,Erten Remzi,BAYRAM YASEMIN,bulut gülay,özbek hanefi The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. Turkish Journal of Gastroenterology 22, no.6 (2011): 594 - 601.
MLA	BAYRAM İrfan,Erten Remzi,BAYRAM YASEMIN,bulut gülay,özbek hanefi The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. Turkish Journal of Gastroenterology, vol.22, no.6, 2011, ss.594 - 601.
AMA	BAYRAM İ,Erten R,BAYRAM Y,bulut g,özbek h The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. Turkish Journal of Gastroenterology. 2011; 22(6): 594 - 601.
Vancouver	BAYRAM İ,Erten R,BAYRAM Y,bulut g,özbek h The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride. Turkish Journal of Gastroenterology. 2011; 22(6): 594 - 601.
IEEE	BAYRAM İ,Erten R,BAYRAM Y,bulut g,özbek h "The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride." Turkish Journal of Gastroenterology, 22, ss.594 - 601, 2011.
ISNAD	BAYRAM, İrfan vd. "The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride". Turkish Journal of Gastroenterology 22/6 (2011), 594-601.