Relationship between total antioxidant capacity and the severity of coronary artery disease

YALÇIN, Kadir Serkan; CANBAL, Metin; NAZLI, Yunus; ERYONUCU, Beyhan; AYDIN, HASAN MURAT; SELÇOKİ, Yusuf; DEMİRÇELİK, Bora; ÇOLAK, Necmettin; YİĞİTOĞLU, Ramazan

Relationship between total antioxidant capacity and the severity of coronary artery disease

Murat AYDIN, (Fatih Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Yusuf SELÇOKİ, (Fatih Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Yunus NAZLI, (Fatih Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Ankara, Türkiye)

Necmettin ÇOLAK, (Fatih Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Ankara, Türkiye)

Kadir Serkan YALÇIN, (Fatih Üniversitesi, Tıp Fakültesi, Ankara, Türkiye)

Metin CANBAL, (Fatih Üniversitesi, Tıp Fakültesi, Aile Hekimliği Anabilim Dalı, Ankara, Türkiye)

Bora DEMİRÇELİK, (Fatih Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Ramazan YİĞİTOĞLU, (Fatih Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Beyhan ERYONUCU (Fatih Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Journal of Clinical and Experimental Investigations

4 0

Yıl: 2012 Cilt: 3 Sayı: 1 Sayfa Aralığı: 22 - 28 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Relationship between total antioxidant capacity and the severity of coronary artery disease

Öz:

Amaç: Koroner arter hastalarında oksidatif/ antioksidatif dengenin oksidatif taraf lehine kaydığı bilinmektedir. Bu çalışmanın amacı, total antioksidan durum, oksidatif yük ve koroner arter hastalığı arasındaki ilişkiyi incelemektir. Gereç ve yöntem: Çalışma grubu, koroner Anjiyografi yapmak için hastaneye yatırılan ardışık 87 hastadan oluşmaktadır. Plazma total oksidatif durum (TOD) ve total antioksidan kapasite (TAK) seviyeleri ölçüldü ve oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Dördüncü gruptaki TAK değerleri ilk grup (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) ile karşılaştırıldığında istatistiksel olarak anlamlı derecede artmıştı ve birinci gruptaki hastalar ile karşılaştırıldığında, dördüncü gruptaki ( 5.2 ± 2.8 vs 7.2 ± 5.4 μmol H2O2 Eq/l) TOD değerlerindeki azalma anlamlı değildi. Hastalıklı damar sayısına göre, plazma oksidatif özellikleri üç grup arasında farklı bulunmadı. Sonuç: Plazma TAK düzeyleri koroner arter hastalığı olan kişilerde artmıştır ve koroner aterosklerozun ağırlığı TAK ile ilişkilidir.

Anahtar Kelime:

Konular: Cerrahi

Total antioksidan kapasite ile koroner arter hastalığı şiddeti arasındaki ilişki

Öz:

Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index. Materials and methods: The study group consisted of 87 consecutive patients who were hospitalized for coronary angiography. Plasma total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and oxidative stress index (OSI) was calculated. Results: The TAC values increased statistically significant in the four tertile compared with the first tertile (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS values decreased non- significantly in the four tertile ( 5.2 ± 2.8 vs 7.2 ± 5.4 μmol H2O2 Eq/l) as compared to the patients in the first tertile. According to the number of diseased vessels, plasma oxidative characteristics did not differ between the three groups. Conclusions: Plasma TAC levels increased in subjects with coronary atherosclerosis and severity of coronary atherosclerosis is related with TAC. J Clin Exp Invest 2012; 3(1): 22-28

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, Lele RD. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India 2004; 52(1): 94-9.
2. Serdar Z, Aslan K, Dirican M, Sarandöl E, Yesilbursa D, Serdar A. Lipid and protein oxidation and antioxidant status in patients with angiographically proven coronary artery disease. Clin Biochem 2006; 39(8):794- 803.
3. Bridges BA, Bowyer DE, Hansen ES, Penn A, Wakabayashi K. The possible involvement of somatic mutations in the development of atherosclerotic plaques. Mutat Res 1990;239 (3):143-8.
4. Nojiri S. Daida H, Mokuno H, et al. Association of serum antioxidant capacity with coronary artery disease in middle-aged men. Jpn Heart J 2001; 42 (6):677-90.
5. Schwenke DC. Antioxidants and atherogenesis. J Nutr Biochem 1998;9: 424-45.
6. Yeum KJ, Russell RM, Krinsky NI, Aldini G. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys 2004;430 (1):97-103.
7. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37(2):112-9.
8. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38(12):1103-11.
9. Gur M, Aslan M, Yildiz A, et al. Paraoxonase and arylesterase activities in coronary artery disease. Eur J Clin Invest 2006; 36(11):779-87.
10. Demirbag R, Yilmaz R, Kocyigit A. Relationship between DNA damage, total antioxidant capacity and coronary artery disease. Mutat Res 2005; 570(2):197- 203.
11. Austen WG, Edwards JE, Frye RL, et al. A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation 1975;51(4 Suppl):5-40.
12. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51(3):606-7.
13. Demirbag R, Gur M, Yilmaz R, Kunt AS, Erel O, Andac MH. Influence of oxidative stress on the development of collateral circulation in total coronary occlusions. Int J Cardiol 2007;116(1):14-9.
14. Young IS, Woodside JV. Antioxidants in health and disease. J Clin Pathol 2001;54(3): 176-86.
15. Lopes HF, Martin KL, Nashar K, Morrow JD, Goodfriend TL, Egan BM. DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity. Hypertension 2003;41(3):422-30.
16. Casalone R, Granata P, Minelli E, et al. Cytogenic analysis reveals clonal proliferation of smooth muscle cells in atherosclerotic plaques. Hum Genet 1991;87(2):139-43.
17. Nia AB, van schooten FJ, Schilderman PAEL, et al. A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms. Carcinogenesis 2001;22(3):395-401.
18. Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J Nutr 2000;130(5):1124- 31.
19. Regnström J, Nilsson J, Tornvall P, Landou C, Hamsten A. Susceptibility to low density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 1992;339(8803):1183-6.
20. Croft KD, Dimmitt SB, Moulton C, Beilin LJ. Low density lipoprotein composition and oxidizability in coronary disease-apparent favourable effect of beta blockers. Atherosclerosis 1992;97(2-3):123-30.
21. Orem C, Orem A, Uydu HA, Celik S, Erdol C, Kural BV. The effects of lipid-lowering therapy on low-density lipoprotein autoantibodies: relationship with lowdensity lipoprotein oxidation and plasma total antioxidant status. Coron Artery Dis. 2002:13(1):65-71.
22. Wayner DD, Burton GW, Ingold KU, Barclay LR, Locke SJ. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochim Biophys Acta 1987;924(3):408-19.
23. Demirbag R, Yilmaz R, Kunt AS, Gur M, Ulucay A, Unlu D. Relation between plasma total anti-oxidant capacity and thoracic aortic intima-media thickness. Echocardiography 2006;23(3):183-88.
24. Gokce N, Frei B. Basic research in antioxidant inhibition of steps in atherogenesis. J Cardiovasc Risk 1996;3(4):352-7.
25. Jialal I, Grundy SM. Effect of combinated supplementation wit α-tocopherol, ascorbate, and β carotene on low-density lipoprotein oxidation. Circulation 1993;88(6):2780-6.
26. Alessio HM, Hagerman AE, Fulkerson BK, Ambrose J, Rice RE, Wiley RL. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med Sci Sports Exerc 2000;32(9):1576-81.

APA	AYDIN H, SELÇOKİ Y, NAZLI Y, ÇOLAK N, YALÇIN K, CANBAL M, DEMİRÇELİK B, YİĞİTOĞLU R, ERYONUCU B (2012). Relationship between total antioxidant capacity and the severity of coronary artery disease. , 22 - 28.
Chicago	AYDIN HASAN MURAT,SELÇOKİ Yusuf,NAZLI Yunus,ÇOLAK Necmettin,YALÇIN Kadir Serkan,CANBAL Metin,DEMİRÇELİK Bora,YİĞİTOĞLU Ramazan,ERYONUCU Beyhan Relationship between total antioxidant capacity and the severity of coronary artery disease. (2012): 22 - 28.
MLA	AYDIN HASAN MURAT,SELÇOKİ Yusuf,NAZLI Yunus,ÇOLAK Necmettin,YALÇIN Kadir Serkan,CANBAL Metin,DEMİRÇELİK Bora,YİĞİTOĞLU Ramazan,ERYONUCU Beyhan Relationship between total antioxidant capacity and the severity of coronary artery disease. , 2012, ss.22 - 28.
AMA	AYDIN H,SELÇOKİ Y,NAZLI Y,ÇOLAK N,YALÇIN K,CANBAL M,DEMİRÇELİK B,YİĞİTOĞLU R,ERYONUCU B Relationship between total antioxidant capacity and the severity of coronary artery disease. . 2012; 22 - 28.
Vancouver	AYDIN H,SELÇOKİ Y,NAZLI Y,ÇOLAK N,YALÇIN K,CANBAL M,DEMİRÇELİK B,YİĞİTOĞLU R,ERYONUCU B Relationship between total antioxidant capacity and the severity of coronary artery disease. . 2012; 22 - 28.
IEEE	AYDIN H,SELÇOKİ Y,NAZLI Y,ÇOLAK N,YALÇIN K,CANBAL M,DEMİRÇELİK B,YİĞİTOĞLU R,ERYONUCU B "Relationship between total antioxidant capacity and the severity of coronary artery disease." , ss.22 - 28, 2012.
ISNAD	AYDIN, HASAN MURAT vd. "Relationship between total antioxidant capacity and the severity of coronary artery disease". (2012), 22-28.

APA	AYDIN H, SELÇOKİ Y, NAZLI Y, ÇOLAK N, YALÇIN K, CANBAL M, DEMİRÇELİK B, YİĞİTOĞLU R, ERYONUCU B (2012). Relationship between total antioxidant capacity and the severity of coronary artery disease. Journal of Clinical and Experimental Investigations, 3(1), 22 - 28.
Chicago	AYDIN HASAN MURAT,SELÇOKİ Yusuf,NAZLI Yunus,ÇOLAK Necmettin,YALÇIN Kadir Serkan,CANBAL Metin,DEMİRÇELİK Bora,YİĞİTOĞLU Ramazan,ERYONUCU Beyhan Relationship between total antioxidant capacity and the severity of coronary artery disease. Journal of Clinical and Experimental Investigations 3, no.1 (2012): 22 - 28.
MLA	AYDIN HASAN MURAT,SELÇOKİ Yusuf,NAZLI Yunus,ÇOLAK Necmettin,YALÇIN Kadir Serkan,CANBAL Metin,DEMİRÇELİK Bora,YİĞİTOĞLU Ramazan,ERYONUCU Beyhan Relationship between total antioxidant capacity and the severity of coronary artery disease. Journal of Clinical and Experimental Investigations, vol.3, no.1, 2012, ss.22 - 28.
AMA	AYDIN H,SELÇOKİ Y,NAZLI Y,ÇOLAK N,YALÇIN K,CANBAL M,DEMİRÇELİK B,YİĞİTOĞLU R,ERYONUCU B Relationship between total antioxidant capacity and the severity of coronary artery disease. Journal of Clinical and Experimental Investigations. 2012; 3(1): 22 - 28.
Vancouver	AYDIN H,SELÇOKİ Y,NAZLI Y,ÇOLAK N,YALÇIN K,CANBAL M,DEMİRÇELİK B,YİĞİTOĞLU R,ERYONUCU B Relationship between total antioxidant capacity and the severity of coronary artery disease. Journal of Clinical and Experimental Investigations. 2012; 3(1): 22 - 28.
IEEE	AYDIN H,SELÇOKİ Y,NAZLI Y,ÇOLAK N,YALÇIN K,CANBAL M,DEMİRÇELİK B,YİĞİTOĞLU R,ERYONUCU B "Relationship between total antioxidant capacity and the severity of coronary artery disease." Journal of Clinical and Experimental Investigations, 3, ss.22 - 28, 2012.
ISNAD	AYDIN, HASAN MURAT vd. "Relationship between total antioxidant capacity and the severity of coronary artery disease". Journal of Clinical and Experimental Investigations 3/1 (2012), 22-28.