Does mode of delivery affect asthma developing in children who had neonatal sepsis?

Bek, Yuksel; ozturk, fadil; SANCAK, Recep; YILDIRAN, Alişan; AYNACI, Eser; KÜÇÜKÖDÜK, Şükrü; AYGÜN, Hasibe Canan

Does mode of delivery affect asthma developing in children who had neonatal sepsis?

Eser AYNACI, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Samsun, Türkiye)

Recep SANCAK, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İmmünoloji ve Allerji Bilim Dalı, Samsun, Türkiye)

Fadıl ÖZTÜRK, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İmmünoloji ve Allerji Bilim Dalı, Samsun, Türkiye)

Yüksel BEK, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Samsun, Türkiye)

Hasibe Canan AYGÜN, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Yenidoğan Bilim Dalı, Samsun, Türkiye)

Şükrü KÜÇÜKÖDÜK, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Yenidoğan Bilim Dalı, Samsun, Türkiye)

Alişan YILDIRAN (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İmmünoloji ve Allerji Bilim Dalı, Samsun, Türkiye)

Astım Allerji İmmünoloji

8 0

Yıl: 2012 Cilt: 10 Sayı: 1 Sayfa Aralığı: 31 - 37 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Does mode of delivery affect asthma developing in children who had neonatal sepsis?

Öz:

Giriş: Bu çalışmanın amacı; doğum şeklinin yenidoğan sepsisi geçirmiş olan çocuklarda astım gelişimine etkisi olup olmadığını araştırmaktır. Yenidoğan sepsisi ve doğum şeklinin çocuklarda astım gelişimi üzerine etkisi olduğu bilinmektedir, ancak her ikisinin aynı grupta değerlendirildiği bir çalışma yoktur. Gereç ve Yöntem: Çalışmaya kanıtlanmış sepsis geçirmiş yenidoğanlar [vajinal yolla (n= 15), elektif sezaryenle (n= 20)] ve onların sağlıklı kardeşleri [vajinal yolla (n= 20), elektif sezaryenle (n= 20)] alındı. Bütün çocuklar ISAAC anketi, fizik muayene, eozinofil sayısı, serum IgE seviyesi ve phadiotop testiyle değerlendirildi. Bulgular: Belirgin hastalık tanımlama ve alınma kriterleri kullanıldığı için çok az allerjik çocuk belirlendi. Risk oranları, astım ve allerjik hastalık gelişimine doğum şekli ve sepsis geçirmiş olmanın etkisi olmadığını gösterdi. Sonuç: Belirgin hastalık tanımı ve alınma kriterleri ile değerlendirildiğinde astım gelişimine doğum şekli ve yenidoğan döneminde sepsis geçirmenin etkisi olmadığı gözlendi.

Anahtar Kelime:

Konular: İmmünoloji

Doğum şeklinin yenidoğan sepsisi geçirmiş çocuklarda astım gelişimine etkisi var mı?

Öz:

Objective: The aim of this study is therefore to evaluate whether mode of delivery (normal versus elective cesarean section) has an influence on the development of asthma in children who had neonatal sepsis. It is known that neonatal sepsis and mode of delivery have some effect on children developing asthma, but no study has evaluated both of these factors in the same group. Materials and Methods: Patients born either vaginally (n= 15) or via elective C-section (n= 20) with proven sepsis and their healthy siblings born either vaginally (n= 20) or via elective C-section (n= 20) were included in the study. All children were evaluated with ISAAC questionnaires, physical examination, eosinophil counts, serum IgE levels, and aeroallergen sensitivity via the Phadiatop test. Results: Only a few allergic infants were observed when they were evaluated with strict inclusion and disease definition criteria. In addition, adjusted risk ratios indicated that both mode of delivery and sepsis had no risk in the development of asthma and allergic diseases. Conclusion: When evaluated with strict inclusion and disease definition criteria, we observed that neither sepsis nor mode of delivery affected the development of asthma in these children.

Anahtar Kelime:

Konular: İmmünoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

+1. Keil T, Kulig M, Simpson A, Custovic A, Wickman M, Kull I, et al. European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs -- a GALEN initiative. Allergy 2006;61:221-8.
2. Okada H, Kuhn C, Feillet H, Bach JF. The 'hygiene hypothesis' for autoimmune and allergic diseases: an update. Clin Exp Immunol 2010;160:1-9.
3. Durrant DM, Metzger DW. Emerging roles of T helper subsets in the pathogenesis of asthma. Immunol Invest 2010;39:526-49.
4. Van Wonderen KE, van der Mark LB, Mohrs J, Bindels PJ, van Aalderen WM, TerRiet G. Different definitions in childhood asthma: how dependable is the dependent variable? Eur Respir J 2010;36:48-56
5. Wandalsen NF, Gonzalez C, Wandalsen GF. Evaluation of criteria for the diagnosis of asthma using an epidemiological questionnaire. J Bras Pneumol 2009;35: 199-205.
6. Çetinkaya F, Uslu H, Nuhoğlu A. Effect of neonatal sepsis on the development of allergies and asthma in later childhood. Allergy Immunol 2007;142:145-50.
7. Ryozawa M, Matsubara T. Clinical sepsis in neonates is responsible fort he lower prevalence of developing allergy. Pediatrics International 2007;49:15-8.
8. Kero J, Gissler M, Grönlund M, Kero P, Koskinen P, Hemminki E, et al. Mode of delivery and asthma-Is there a connection? Pediatr Res 2002;52:6-11.
9. Negele K, Heinrich J, Borte M, van Berg A, Schaaf B, Lehmann I, et al. Mode of delivery and development of atopic disease during the first 2 years of life. Pediatr Allergy Immunol 2004;15:48-54.
10. Yıldıran A, İkincioğulları A. Does mode of delivery affect T regulatory (Treg) cells in cord blood? Oral presentation, EAACI 2009, Warsaw.
11. Kücüködük S, Sezer T, Yildiran A, Albayrak D. Randomized, double-blinded, placebo-controlled trial of early administration of recombinant human granulocyte colony- stimulating factor to non-neutropenic preterm newborns between 33 and 36 weeks with presumed sepsis. Scand J Infect Dis 2002;34:893-7.
12. ISAAC (Sterring Committee. The International Study of Asthma and Allergies in Childhood) Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema. Lancet 1998;351:1225-32.
13. Vanna AT, Yamada E, Arruda LK, Naspitz CK, SoleÂ D. International Study of Asthma and Allergies in Childhood: Validation of the rhinitis symptom questionnaire and prevalence of rhinitis in schoolchildren in Brazil. Pediatr Allergy Immunol 2001;12:95-101.
14. Liu AH, Spahn JD, Leung DYM. Childhood asthma. In: Behrman RE, Kliegman RM, Jenson HB (eds). Nelson Textbook of Pediatrics. 17th ed. Philadelphia. 2004:761-74.
15. Garcia-Marcos L, Sanchez-Solis M, Martinez-Torres AE, Lucas Moreno JM, Hernando Sastre V. Phadiatop ™compared to skin-prick test as a tool for diagnosing atopy in epidemiological studies in schoolchildren. Pediatr Allergy Immunol 2007;18:240-4.
16. Kjellman NM, Johansson SG, Roth A. Serum IgE levels in healthy children quantified by a sandwich technique (PRIST). Clin Allergy 1976;6:51-9.
17. Oshma Y, Yamada A, Hiraoka M, Katamura K, Ito S, Hirao T, et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: results of a 4 year follow up study. Ann Allergy Asthma Immunol 2002;89:265-70.
18. Sobko T, Schiött J, Ehlin A, Lundberg J, Montgomery S, Norman M. Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy. Paediatr Perinat Epidemiol 2010;24:88-92.
19. Kopp MV, Semmler S, Ihorst G, Berner R, Forster J. Hospital admission with neonatal sepsis and development of atopic disease: Is there a link? Pediatr Allergy Immunol 2005;16:630-6.
20. Tollånes MC, Moster D, Daltveit AK, Irgens LM. Cesarean section and risk of severe childhood asthma: a population- based cohort study. J Pediatr 2008;153:112- 6.
21. VanBeijsterveldt TC, Boomsma DI. Asthma and mode of birth delivery: a study in 5-year-old Dutch twins. Twin Res Hum Genet 2008;11:156-60.
22. Renz-Polster H, David MR, Buist AS, Volmer WM, O’Connor EA, Frazier EA, et al. Caesarean section delivery and the risk of allergic disorders in childhood. Clin Exp Allergy 2005;35:1466-72.
23. Salam MT, Margolis HG, McConnell R, McGregor JA, Avol EL, Gilliland FD. Mode of delivery is associated with asthma and allergy occurrences in children. Ann Epidemiol 2006;16:341-6.
24. Maitra A, Sherriff A, Strachan D, Henderson J; ALSPAC Study Team. Mode of delivery is not associated with asthma or atopy in childhood. Clin Exp Allergy 2004;34:1349-55.
25. McKeever TM, Lewis SA, Smith C, Hubbard R. Mode of delivery and risk of developing allergic disease. J Allergy Clin Immunol 2002;109:800-2.
26. Park YH, Kim KW, Choi BS, Jee HM, Sohn MH, Kim KE. Relationship between mode of delivery in childbirth and prevalence of allergic diseases in Korean children. Allergy Asthma Immunol Res 2010;2:28-33.
27. Pistiner M, Gold DR, Abdulkerim H, Hoffman E, Celedón JC. Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy. J Allergy Clin Immunol 2008;122:274-9.

APA	AYNACI E, SANCAK R, ozturk f, Bek Y, AYGÜN H, KÜÇÜKÖDÜK Ş, YILDIRAN A (2012). Does mode of delivery affect asthma developing in children who had neonatal sepsis?. , 31 - 37.
Chicago	AYNACI Eser,SANCAK Recep,ozturk fadil,Bek Yuksel,AYGÜN Hasibe Canan,KÜÇÜKÖDÜK Şükrü,YILDIRAN Alişan Does mode of delivery affect asthma developing in children who had neonatal sepsis?. (2012): 31 - 37.
MLA	AYNACI Eser,SANCAK Recep,ozturk fadil,Bek Yuksel,AYGÜN Hasibe Canan,KÜÇÜKÖDÜK Şükrü,YILDIRAN Alişan Does mode of delivery affect asthma developing in children who had neonatal sepsis?. , 2012, ss.31 - 37.
AMA	AYNACI E,SANCAK R,ozturk f,Bek Y,AYGÜN H,KÜÇÜKÖDÜK Ş,YILDIRAN A Does mode of delivery affect asthma developing in children who had neonatal sepsis?. . 2012; 31 - 37.
Vancouver	AYNACI E,SANCAK R,ozturk f,Bek Y,AYGÜN H,KÜÇÜKÖDÜK Ş,YILDIRAN A Does mode of delivery affect asthma developing in children who had neonatal sepsis?. . 2012; 31 - 37.
IEEE	AYNACI E,SANCAK R,ozturk f,Bek Y,AYGÜN H,KÜÇÜKÖDÜK Ş,YILDIRAN A "Does mode of delivery affect asthma developing in children who had neonatal sepsis?." , ss.31 - 37, 2012.
ISNAD	AYNACI, Eser vd. "Does mode of delivery affect asthma developing in children who had neonatal sepsis?". (2012), 31-37.

APA	AYNACI E, SANCAK R, ozturk f, Bek Y, AYGÜN H, KÜÇÜKÖDÜK Ş, YILDIRAN A (2012). Does mode of delivery affect asthma developing in children who had neonatal sepsis?. Astım Allerji İmmünoloji, 10(1), 31 - 37.
Chicago	AYNACI Eser,SANCAK Recep,ozturk fadil,Bek Yuksel,AYGÜN Hasibe Canan,KÜÇÜKÖDÜK Şükrü,YILDIRAN Alişan Does mode of delivery affect asthma developing in children who had neonatal sepsis?. Astım Allerji İmmünoloji 10, no.1 (2012): 31 - 37.
MLA	AYNACI Eser,SANCAK Recep,ozturk fadil,Bek Yuksel,AYGÜN Hasibe Canan,KÜÇÜKÖDÜK Şükrü,YILDIRAN Alişan Does mode of delivery affect asthma developing in children who had neonatal sepsis?. Astım Allerji İmmünoloji, vol.10, no.1, 2012, ss.31 - 37.
AMA	AYNACI E,SANCAK R,ozturk f,Bek Y,AYGÜN H,KÜÇÜKÖDÜK Ş,YILDIRAN A Does mode of delivery affect asthma developing in children who had neonatal sepsis?. Astım Allerji İmmünoloji. 2012; 10(1): 31 - 37.
Vancouver	AYNACI E,SANCAK R,ozturk f,Bek Y,AYGÜN H,KÜÇÜKÖDÜK Ş,YILDIRAN A Does mode of delivery affect asthma developing in children who had neonatal sepsis?. Astım Allerji İmmünoloji. 2012; 10(1): 31 - 37.
IEEE	AYNACI E,SANCAK R,ozturk f,Bek Y,AYGÜN H,KÜÇÜKÖDÜK Ş,YILDIRAN A "Does mode of delivery affect asthma developing in children who had neonatal sepsis?." Astım Allerji İmmünoloji, 10, ss.31 - 37, 2012.
ISNAD	AYNACI, Eser vd. "Does mode of delivery affect asthma developing in children who had neonatal sepsis?". Astım Allerji İmmünoloji 10/1 (2012), 31-37.