Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?

ATİK, O. Şahap

Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?

O. Şahap ATİK (Gazi Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Ankara, Türkiye)

Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.)

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Yıl: 2012 Cilt: 23 Sayı: 3 Sayfa Aralığı: 166 - 167 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?

Öz:

Ameliyat olacak hastalarda traneksamik asidin total diz artroplastisindeki kan kaybı ve kan transfüzyonu gereksinimini azalttığına ilişkin güçlü deliller vardır. Bununla birlikte, doz ve veriliş yöntemi, güvenlik ve yan etkiler konuları tartışmalıdır. Traneksamik asidin tromboembolik olaylar ve mortal ite üzerine etkisi henüz netleşmemiştir.

Anahtar Kelime:

Konular: Ortopedi

Traneksamik asit total diz artroplastisindeki kan kaybı ve kan transfüzyonu gereksinimi azaltır mı?

Öz:

Strong evidences which indicate that tranexamic acid reduces blood loss and blood transfusion requirement in patients who are scheduled for total knee arthroplasty are available. However, dose and method of administration, safety and side effects are still controversial issues. The effect of tranexamic acid on thromboembolic events and mortality is still unknown.

Anahtar Kelime:

Konular: Ortopedi

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

1. Benoni G, Carlsson A, Petersson C, Fredin H. Does tranexamic acid reduce blood loss in knee arthroplasty? Am J Knee Surg 1995;8:88-92.
2. Ido K, Neo M, Asada Y, Kondo K, Morita T, Sakamoto T, et al. Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties. Arch Orthop Trauma Surg 2000;120:518-20.
3. Charoencholvanich K, Siriwattanasakul P. Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clin Orthop Relat Res 2011;469:2874-80.
4. Maniar RN, Kumar G, Singhi T, Nayak RM, Maniar PR. Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res 2012;470:2605-12.
5. Benoni G, Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg [Brj 1996;78:434-40.
6. Wong J, Abrishami A, El Beheiry H, Mahomed NN, Roderick Davey J, Gandhi R, et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg [Am] 2010;92:2503-13.
7. Yang ZG, Chen WP, Wu LD. Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg [Am] 2012;94:1153-9.
8. Sarban S, Atik OS. The effects of using a tourniquet during total knee arthroplasty. Eklem Hastalik Cerrahisi 1998:9:19-21.
9. Erdoğan D, Omeroğlu S, Sarban S, Atik OS. Prevention of oxidative stress due to tourniquet application. Analysis of the effects of local hypothermia and systemic allopurinol administration. Acta Orthop Belg 1999;65:164-9.
10. Burkart BC, Bourne RB, Rorabeck CH, Kirk PG, Nott L. The efficacy of tourniquet release in blood conservation after total knee arthroplasty. Clin Orthop Relat Res 1994;299:147-52.
11. Nakahara M, Sakahashi H. Effect of application of a tourniquet on bleeding factors in dogs. J Bone Joint Surg [Am] 1967;49:1345-51.
12. Fahmy NR, Patel DG. Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet. J Bone Joint Surg [Am] 1981;63:461-5.
13. Orpen NM, Little C, Walker G, Crawfurd EJ. Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients. Knee 2006;13:106-10.
14. Good L, Peterson E, Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 2003;90:596-9.
15. Ralley FE, Berta D, Binns V, Howard J, Naudie DD. One intraoperative dose of tranexamic Acid for patients having primary hip or knee arthroplasty. Clin Orthop Relat Res 2010;468:1905-11.
16. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S. Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg [Br] 2001;83:702-5.
17. Lin PC, Hsu CH, Chen WS, Wang JW. Does tranexamic acid save blood in minimally invasive total knee arthroplasty? Clin Orthop Relat Res 2011;469:1995-2002.
18. Lin PC, Hsu CH, Huang CC, Chen WS, Wang JW. The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional pre-operative injection effective? J Bone Joint Surg [Br[ 2012;94:932-6.
19. Aguilera X, Videla S, Almenara M, Fernandez JA, Gich I, Celaya F. Effectiveness of tranexamic acid in revision total knee arthroplasty. Acta Orthop Belg 2012;78:68-74.
20. Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012;344:e3054.

APA	ATİK O (2012). Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. , 166 - 167.
Chicago	ATİK O. Şahap Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. (2012): 166 - 167.
MLA	ATİK O. Şahap Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. , 2012, ss.166 - 167.
AMA	ATİK O Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. . 2012; 166 - 167.
Vancouver	ATİK O Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. . 2012; 166 - 167.
IEEE	ATİK O "Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?." , ss.166 - 167, 2012.
ISNAD	ATİK, O. Şahap. "Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?". (2012), 166-167.

APA	ATİK O (2012). Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), 23(3), 166 - 167.
Chicago	ATİK O. Şahap Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) 23, no.3 (2012): 166 - 167.
MLA	ATİK O. Şahap Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), vol.23, no.3, 2012, ss.166 - 167.
AMA	ATİK O Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.). 2012; 23(3): 166 - 167.
Vancouver	ATİK O Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.). 2012; 23(3): 166 - 167.
IEEE	ATİK O "Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?." Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), 23, ss.166 - 167, 2012.
ISNAD	ATİK, O. Şahap. "Does tranexamic acid reduce blood loss and blood transfusion requirement in knee arthroplasty?". Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) 23/3 (2012), 166-167.